Conservation of cofitness between b3368 and b3771 in Escherichia coli BW25113

55 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b3368 cysG fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) 1.0 b3771 ilvD dihydroxy-acid dehydratase (NCBI) 0.93 14
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_00334 Siroheme synthase 1.00 OHPLBJKB_04282 Dihydroxy-acid dehydratase low > 73
Escherichia coli BL21 1.00 ECD_03219 fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase 1.00 ECD_03649 dihydroxyacid dehydratase low > 60
Escherichia coli ECRC102 1.00 NIAGMN_14950 cysG siroheme synthase CysG 1.00 NIAGMN_12395 ilvD dihydroxy-acid dehydratase — —
Escherichia fergusonii Becca 1.00 EFB2_00454 Siroheme synthase 0.99 EFB2_04865 Dihydroxy-acid dehydratase low > 86
Escherichia coli Nissle 1917 1.00 ECOLIN_RS19285 siroheme synthase CysG 0.99 ECOLIN_RS21665 dihydroxy-acid dehydratase low > 52
Escherichia coli ECRC98 1.00 JDDGAC_20810 cysG siroheme synthase CysG 1.00 JDDGAC_18260 ilvD dihydroxy-acid dehydratase — —
Escherichia coli ECRC101 1.00 OKFHMN_17180 cysG siroheme synthase CysG 1.00 OKFHMN_14640 ilvD dihydroxy-acid dehydratase — —
Escherichia coli ECRC101 1.00 MCAODC_07710 cysG siroheme synthase CysG 1.00 MCAODC_05145 ilvD dihydroxy-acid dehydratase — —
Escherichia coli ECRC99 1.00 KEDOAH_10960 cysG siroheme synthase CysG 1.00 KEDOAH_13510 ilvD dihydroxy-acid dehydratase — —
Escherichia coli ECOR27 1.00 NOLOHH_08980 cysG siroheme synthase CysG 1.00 NOLOHH_06775 ilvD dihydroxy-acid dehydratase low > 57
Escherichia coli ECOR38 1.00 HEPCGN_16010 cysG siroheme synthase CysG 1.00 HEPCGN_13350 ilvD dihydroxy-acid dehydratase low > 85
Escherichia coli ECRC62 1.00 BNILDI_02540 cysG siroheme synthase CysG 1.00 BNILDI_04750 ilvD dihydroxy-acid dehydratase — —
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.92 GFF3700 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.97 GFF2901 Dihydroxy-acid dehydratase (EC 4.2.1.9) 0.31 63
Enterobacter asburiae PDN3 0.89 EX28DRAFT_4160 uroporphyrin-III C-methyltransferase 0.96 EX28DRAFT_4443 dihydroxy-acid dehydratase 0.64 7
Enterobacter sp. TBS_079 0.89 MPMX20_04271 Siroheme synthase 0.97 MPMX20_04499 Dihydroxy-acid dehydratase low > 85
Klebsiella michiganensis M5al 0.88 BWI76_RS26055 siroheme synthase 0.96 BWI76_RS00975 dihydroxy-acid dehydratase 0.79 17
Pectobacterium carotovorum WPP14 0.72 HER17_RS01835 siroheme synthase CysG 0.91 HER17_RS01075 dihydroxy-acid dehydratase low > 75
Serratia liquefaciens MT49 0.71 IAI46_23670 uroporphyrinogen-III C-methyltransferase 0.90 IAI46_24345 dihydroxy-acid dehydratase low > 86
Rahnella sp. WP5 0.71 EX31_RS04680 uroporphyrinogen-III C-methyltransferase 0.87 EX31_RS15005 dihydroxy-acid dehydratase low > 89
Erwinia tracheiphila SCR3 0.53 LU632_RS06420 cysG siroheme synthase CysG 0.86 LU632_RS24400 ilvD dihydroxy-acid dehydratase 0.78 42
Dickeya dianthicola 67-19 0.51 HGI48_RS17000 uroporphyrinogen-III C-methyltransferase 0.91 HGI48_RS20295 dihydroxy-acid dehydratase 0.79 12
Dickeya dadantii 3937 0.51 DDA3937_RS16930 uroporphyrinogen-III C-methyltransferase 0.92 DDA3937_RS20155 dihydroxy-acid dehydratase 0.81 41
Pseudomonas stutzeri RCH2 0.51 Psest_2037 uroporphyrin-III C-methyltransferase 0.75 Psest_0234 dihydroxy-acid dehydratase — —
Dickeya dianthicola ME23 0.50 DZA65_RS18075 uroporphyrinogen-III C-methyltransferase 0.91 DZA65_RS21335 dihydroxy-acid dehydratase 0.78 27
Pantoea sp. MT58 0.50 IAI47_04175 uroporphyrinogen-III C-methyltransferase 0.89 IAI47_01035 dihydroxy-acid dehydratase 0.83 30
Pseudomonas syringae pv. syringae B728a 0.49 Psyr_3174 uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase 0.74 Psyr_0469 dihydroxyacid dehydratase 0.83 8
Pseudomonas syringae pv. syringae B728a ΔmexB 0.49 Psyr_3174 uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase 0.74 Psyr_0469 dihydroxyacid dehydratase 0.65 15
Pseudomonas sp. RS175 0.49 PFR28_02603 Siroheme synthase 0.75 PFR28_04278 Dihydroxy-acid dehydratase 0.76 4
Pseudomonas fluorescens FW300-N2C3 0.49 AO356_22200 sirohydrochlorin ferrochelatase 0.75 AO356_13250 dihydroxy-acid dehydratase 0.85 15
Pseudomonas fluorescens FW300-N1B4 0.49 Pf1N1B4_4065 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.75 Pf1N1B4_2303 Dihydroxy-acid dehydratase (EC 4.2.1.9) 0.90 8
Pseudomonas fluorescens FW300-N2E2 0.49 Pf6N2E2_302 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.75 Pf6N2E2_4564 Dihydroxy-acid dehydratase (EC 4.2.1.9) 0.77 17
Pseudomonas fluorescens GW456-L13 0.49 PfGW456L13_2656 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.75 PfGW456L13_973 Dihydroxy-acid dehydratase (EC 4.2.1.9) 0.91 19
Pseudomonas fluorescens FW300-N2E3 0.49 AO353_27625 sirohydrochlorin ferrochelatase 0.75 AO353_08345 dihydroxy-acid dehydratase — —
Pseudomonas simiae WCS417 0.48 PS417_16465 sirohydrochlorin ferrochelatase 0.75 PS417_26890 dihydroxy-acid dehydratase 0.80 18
Pseudomonas fluorescens SBW25-INTG 0.48 PFLU_RS18505 uroporphyrinogen-III C-methyltransferase 0.75 PFLU_RS28535 dihydroxy-acid dehydratase 0.63 6
Pseudomonas fluorescens SBW25 0.48 PFLU_RS18505 uroporphyrinogen-III C-methyltransferase 0.75 PFLU_RS28535 dihydroxy-acid dehydratase low > 109
Pseudomonas putida KT2440 0.47 PP_3999 Uroporphyrinogen-III C-methyltransferase/Precorrin-2 dehydrogenase/Sirohydrochlorin ferrochelatase 0.74 PP_5128 Dihydroxy-acid dehydratase 0.78 10
Acinetobacter radioresistens SK82 0.45 MPMX26_00706 Siroheme synthase 0.29 MPMX26_03019 Dihydroxy-acid dehydratase — —
Pseudomonas sp. S08-1 0.45 OH686_00285 Precorrin-2 oxidase or Sirohydrochlorin ferrochelatase activity of CysG / Uroporphyrinogen-III methyltransferase 0.75 OH686_14100 dihydroxy-acid dehydratase low > 80
Alteromonas macleodii MIT1002 0.45 MIT1002_00665 Siroheme synthase 0.79 MIT1002_04041 Dihydroxy-acid dehydratase — —
Dyella japonica UNC79MFTsu3.2 0.44 ABZR86_RS05880 siroheme synthase CysG 0.28 ABZR86_RS15945 dihydroxy-acid dehydratase 0.84 52
Lysobacter sp. OAE881 0.43 ABIE51_RS15855 siroheme synthase CysG 0.27 ABIE51_RS17540 dihydroxy-acid dehydratase 0.96 27
Castellaniella sp019104865 MT123 0.40 ABCV34_RS00210 siroheme synthase CysG 0.72 ABCV34_RS14810 dihydroxy-acid dehydratase low > 48
Rhodanobacter sp. FW510-T8 0.40 OKGIIK_05980 cysG siroheme synthase CysG 0.27 OKGIIK_13600 ilvD dihydroxy-acid dehydratase low > 52
Rhodanobacter denitrificans FW104-10B01 0.38 LRK54_RS00910 siroheme synthase CysG 0.26 LRK54_RS10320 dihydroxy-acid dehydratase 0.66 25
Rhodanobacter denitrificans MT42 0.37 LRK55_RS00685 siroheme synthase CysG 0.26 LRK55_RS09960 dihydroxy-acid dehydratase low > 63
Agrobacterium fabrum C58 0.33 Atu3899 siroheme synthase 0.73 Atu1918 dihydroxy-acid dehydratase — —
Sinorhizobium meliloti 1021 0.32 SMc01053 siroheme synthase 0.75 SMc04045 dihydroxy-acid dehydratase 0.95 15
Rhizobium sp. OAE497 0.31 ABIE40_RS09140 siroheme synthase CysG 0.75 ABIE40_RS08005 dihydroxy-acid dehydratase 0.82 77
Brevundimonas sp. GW460-12-10-14-LB2 0.31 A4249_RS09675 siroheme synthase CysG 0.25 A4249_RS10030 dihydroxy-acid dehydratase 1.00 6
Rhodopseudomonas palustris CGA009 0.30 TX73_021850 siroheme synthase CysG 0.74 TX73_007515 dihydroxy-acid dehydratase — —
Rhodospirillum rubrum S1H 0.27 Rru_A1933 Uroporphyrin-III C-methyltransferase (NCBI) 0.71 Rru_A1786 Dihydroxy-acid dehydratase (NCBI) low > 58
Dinoroseobacter shibae DFL-12 0.27 Dshi_1155 uroporphyrin-III C-methyltransferase (RefSeq) 0.31 Dshi_0129 dihydroxy-acid dehydratase (RefSeq) — —
Bosea sp. OAE506 0.26 ABIE41_RS15910 siroheme synthase CysG 0.29 ABIE41_RS15690 dihydroxy-acid dehydratase — —
Mycobacterium tuberculosis H37Rv 0.20 Rv2847c Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase 0.31 Rv0189c Probable dihydroxy-acid dehydratase IlvD (dad) — —

Not shown: 1 genomes with orthologs for b3368 only; 46 genomes with orthologs for b3771 only