Conservation of cofitness between b2476 and b4006 in Escherichia coli BW25113

57 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b2476 purC phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) 1.0 b4006 purH bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) 0.94 4
Escherichia coli ECOR38 1.00 HEPCGN_21100 purC phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.99 HEPCGN_11950 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase low > 85
Escherichia coli ECRC101 1.00 MCAODC_12460 purC phosphoribosylaminoimidazolesuccinocarboxamide synthase 1.00 MCAODC_03810 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Escherichia coli ECRC102 1.00 NIAGMN_19700 purC phosphoribosylaminoimidazolesuccinocarboxamide synthase 1.00 NIAGMN_11060 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Escherichia coli ECRC99 1.00 KEDOAH_06290 purC phosphoribosylaminoimidazolesuccinocarboxamide synthase 1.00 KEDOAH_14850 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Escherichia coli ECRC62 1.00 BNILDI_12400 purC phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.99 BNILDI_06065 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Escherichia coli ECRC101 1.00 OKFHMN_21930 purC phosphoribosylaminoimidazolesuccinocarboxamide synthase 1.00 OKFHMN_13310 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Escherichia coli Nissle 1917 1.00 ECOLIN_RS14130 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.99 ECOLIN_RS23100 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Escherichia coli ECOR27 1.00 NOLOHH_13590 purC phosphoribosylaminoimidazolesuccinocarboxamide synthase 1.00 NOLOHH_05455 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Escherichia coli BL21 1.00 ECD_02368 phosphoribosylaminoimidazole-succinocarboxamide synthetase 1.00 ECD_03883 IMP cyclohydrolase and phosphoribosylaminoimidazolecarboxamide formyltransferase — —
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_01254 Phosphoribosylaminoimidazole-succinocarboxamide synthase 0.99 OHPLBJKB_04043 Bifunctional purine biosynthesis protein PurH 0.34 36
Escherichia coli ECRC98 1.00 JDDGAC_25875 purC phosphoribosylaminoimidazolesuccinocarboxamide synthase 1.00 JDDGAC_16935 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Escherichia fergusonii Becca 1.00 EFB2_01411 Phosphoribosylaminoimidazole-succinocarboxamide synthase 0.99 EFB2_04604 Bifunctional purine biosynthesis protein PurH low > 86
Enterobacter asburiae PDN3 0.97 EX28DRAFT_0184 phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) 0.94 EX28DRAFT_4545 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) — —
Enterobacter sp. TBS_079 0.97 MPMX20_03338 Phosphoribosylaminoimidazole-succinocarboxamide synthase 0.94 MPMX20_00226 Bifunctional purine biosynthesis protein PurH 0.95 1
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.97 GFF2182 Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) 0.96 GFF4186 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) low > 78
Klebsiella michiganensis M5al 0.96 BWI76_RS20895 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.94 BWI76_RS01615 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosine monophosphate cyclohydrolase 0.91 2
Rahnella sp. WP5 0.92 EX31_RS22750 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.88 EX31_RS16860 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.96 1
Serratia liquefaciens MT49 0.91 IAI46_18770 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.89 IAI46_01365 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.72 2
Pectobacterium carotovorum WPP14 0.91 HER17_RS15405 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.90 HER17_RS20335 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.95 2
Pantoea sp. MT58 0.90 IAI47_05275 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.90 IAI47_18040 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.96 4
Dickeya dadantii 3937 0.90 DDA3937_RS06075 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.91 DDA3937_RS01220 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.86 3
Dickeya dianthicola ME23 0.89 DZA65_RS06470 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.90 DZA65_RS01260 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.92 3
Dickeya dianthicola 67-19 0.89 HGI48_RS06120 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.90 HGI48_RS01215 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.78 8
Erwinia tracheiphila SCR3 0.88 LU632_RS08335 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.88 LU632_RS01020 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.90 1
Pseudomonas syringae pv. syringae B728a ΔmexB 0.74 Psyr_1551 phosphoribosylaminoimidazole-succinocarboxamide synthase 0.68 Psyr_4406 IMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase — —
Pseudomonas syringae pv. syringae B728a 0.74 Psyr_1551 phosphoribosylaminoimidazole-succinocarboxamide synthase 0.68 Psyr_4406 IMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase — —
Pseudomonas fluorescens FW300-N2E3 0.73 AO353_17685 phosphoribosylaminoimidazole-succinocarboxamide synthase 0.69 AO353_13650 phosphoribosylaminoimidazolecarboxamide formyltransferase — —
Pseudomonas putida KT2440 0.72 PP_1240 Phosphoribosylaminoimidazole-succinocarboxamide synthase 0.68 PP_4822 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Pseudomonas sp. RS175 0.71 PFR28_00702 Phosphoribosylaminoimidazole-succinocarboxamide synthase 0.69 PFR28_05214 Bifunctional purine biosynthesis protein PurH — —
Pseudomonas fluorescens FW300-N1B4 0.71 Pf1N1B4_3335 Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) 0.70 Pf1N1B4_1315 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) — —
Alteromonas macleodii MIT1002 0.71 MIT1002_02205 Phosphoribosylaminoimidazole-succinocarboxamide synthase 0.76 MIT1002_03959 Bifunctional purine biosynthesis protein PurH — —
Pseudomonas fluorescens GW456-L13 0.71 PfGW456L13_4504 Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) 0.69 PfGW456L13_57 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) — —
Marinobacter adhaerens HP15 0.70 HP15_2025 phosphoribosylaminoimidazole-succinocarboxamide synthase 0.72 HP15_3227 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Pseudomonas fluorescens SBW25 0.68 PFLU_RS07290 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.69 PFLU_RS03015 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH — —
Pseudomonas simiae WCS417 0.68 PS417_07180 phosphoribosylaminoimidazole-succinocarboxamide synthase 0.69 PS417_02940 phosphoribosylaminoimidazolecarboxamide formyltransferase — —
Pseudomonas fluorescens SBW25-INTG 0.68 PFLU_RS07290 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.69 PFLU_RS03015 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH — —
Pseudomonas fluorescens FW300-N2C3 0.68 AO356_04515 phosphoribosylaminoimidazole-succinocarboxamide synthase 0.69 AO356_08225 phosphoribosylaminoimidazolecarboxamide formyltransferase — —
Pseudomonas fluorescens FW300-N2E2 0.67 Pf6N2E2_2744 Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) 0.69 Pf6N2E2_3519 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) — —
Acinetobacter radioresistens SK82 0.61 MPMX26_02984 Phosphoribosylaminoimidazole-succinocarboxamide synthase 0.69 MPMX26_01141 Bifunctional purine biosynthesis protein PurH 0.97 2
Sinorhizobium meliloti 1021 0.45 SMc00495 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.47 SMc04088 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.96 1
Rhizobium sp. OAE497 0.44 ABIE40_RS10140 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.47 ABIE40_RS19130 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.74 40
Bosea sp. OAE506 0.44 ABIE41_RS05015 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.51 ABIE41_RS05095 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase low > 77
Agrobacterium fabrum C58 0.44 Atu1843 phosphoribosylaminoimidazole-succinocarboxamide synthase 0.46 Atu2823 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Azospirillum sp. SherDot2 0.43 MPMX19_00448 Phosphoribosylaminoimidazole-succinocarboxamide synthase 0.54 MPMX19_02325 Bifunctional purine biosynthesis protein PurH — —
Fusobacterium nucleatum SB010 0.43 HUW76_05165 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.44 HUW76_05195 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.98 11
Magnetospirillum magneticum AMB-1 0.43 AMB_RS07775 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.49 AMB_RS00505 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH — —
Azospirillum brasilense Sp245 0.43 AZOBR_RS04370 phosphoribosylaminoimidazole-succinocarboxamide synthase 0.51 AZOBR_RS00225 purine biosynthesis protein purH — —
Rhodopseudomonas palustris CGA009 0.43 TX73_019780 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.52 TX73_000145 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Rhodospirillum rubrum S1H 0.42 Rru_A0711 phosphoribosylaminoimidazole-succinocarboxamidesynthase (RefSeq) 0.49 Rru_A3655 Phosphoribosylaminoimidazolecarboxamideformyltransferase (NCBI) — —
Brevundimonas sp. GW460-12-10-14-LB2 0.41 A4249_RS00890 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.44 A4249_RS13150 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Caulobacter crescentus NA1000 Δfur 0.41 CCNA_02576 phosphoribosylamidoimidazole-succinocarboxamide synthase 0.47 CCNA_00084 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase low > 67
Caulobacter crescentus NA1000 0.41 CCNA_02576 phosphoribosylamidoimidazole-succinocarboxamide synthase 0.47 CCNA_00084 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase low > 66
Phaeobacter inhibens DSM 17395 0.41 PGA1_c13400 phosphoribosylaminoimidazole-succinocarboxamide synthase PurC 0.52 PGA1_c32860 bifunctional purine biosynthesis protein PurH — —
Dinoroseobacter shibae DFL-12 0.40 Dshi_1076 phosphoribosylaminoimidazole-succinocarboxamidesynthase (RefSeq) 0.50 Dshi_0358 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (RefSeq) — —
Bifidobacterium breve UCC2003 0.39 BBR_RS13450 phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.35 BBR_RS15690 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH — —
Sphingomonas koreensis DSMZ 15582 0.39 Ga0059261_1526 phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) 0.49 Ga0059261_2242 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —
Synechococcus elongatus PCC 7942 0.35 Synpcc7942_0927 purC phosphoribosylaminoimidazole-succinocarboxamide synthase 0.42 Synpcc7942_0396 purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase — —

Not shown: 2 genomes with orthologs for b2476 only; 42 genomes with orthologs for b4006 only