Conservation of cofitness between b3368 and b0071 in Escherichia coli BW25113

55 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b3368 cysG fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) 1.0 b0071 leuD isopropylmalate isomerase small subunit (NCBI) 0.92 18
Escherichia coli BL21 1.00 ECD_03219 fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase 1.00 ECD_00073 3-isopropylmalate dehydratase small subunit low > 60
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_00334 Siroheme synthase 1.00 OHPLBJKB_03586 3-isopropylmalate dehydratase small subunit low > 73
Escherichia coli ECRC102 1.00 NIAGMN_14950 cysG siroheme synthase CysG 0.99 NIAGMN_08580 leuD 3-isopropylmalate dehydratase small subunit — —
Escherichia coli ECRC98 1.00 JDDGAC_20810 cysG siroheme synthase CysG 0.99 JDDGAC_14325 leuD 3-isopropylmalate dehydratase small subunit — —
Escherichia coli ECRC99 1.00 KEDOAH_10960 cysG siroheme synthase CysG 0.99 KEDOAH_17425 leuD 3-isopropylmalate dehydratase small subunit — —
Escherichia fergusonii Becca 1.00 EFB2_00454 Siroheme synthase 0.99 EFB2_03974 3-isopropylmalate dehydratase small subunit low > 86
Escherichia coli Nissle 1917 1.00 ECOLIN_RS19285 siroheme synthase CysG 0.99 ECOLIN_RS00385 3-isopropylmalate dehydratase small subunit low > 52
Escherichia coli ECRC101 1.00 OKFHMN_17180 cysG siroheme synthase CysG 0.99 OKFHMN_10730 leuD 3-isopropylmalate dehydratase small subunit — —
Escherichia coli ECRC101 1.00 MCAODC_07710 cysG siroheme synthase CysG 0.99 MCAODC_01245 leuD 3-isopropylmalate dehydratase small subunit — —
Escherichia coli ECOR38 1.00 HEPCGN_16010 cysG siroheme synthase CysG 0.99 HEPCGN_08710 leuD 3-isopropylmalate dehydratase small subunit low > 85
Escherichia coli ECRC62 1.00 BNILDI_02540 cysG siroheme synthase CysG 1.00 BNILDI_08535 leuD 3-isopropylmalate dehydratase small subunit — —
Escherichia coli ECOR27 1.00 NOLOHH_08980 cysG siroheme synthase CysG 1.00 NOLOHH_03075 leuD 3-isopropylmalate dehydratase small subunit low > 57
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.92 GFF3700 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.92 GFF167 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) low > 78
Enterobacter asburiae PDN3 0.89 EX28DRAFT_4160 uroporphyrin-III C-methyltransferase 0.89 EX28DRAFT_3667 3-isopropylmalate dehydratase, small subunit 0.58 34
Enterobacter sp. TBS_079 0.89 MPMX20_04271 Siroheme synthase 0.90 MPMX20_00766 3-isopropylmalate dehydratase small subunit 1 0.33 30
Klebsiella michiganensis M5al 0.88 BWI76_RS26055 siroheme synthase 0.89 BWI76_RS04665 3-isopropylmalate dehydratase small subunit 0.81 8
Pectobacterium carotovorum WPP14 0.72 HER17_RS01835 siroheme synthase CysG 0.82 HER17_RS03070 3-isopropylmalate dehydratase small subunit low > 75
Rahnella sp. WP5 0.71 EX31_RS04680 uroporphyrinogen-III C-methyltransferase 0.84 EX31_RS03695 3-isopropylmalate dehydratase small subunit low > 89
Serratia liquefaciens MT49 0.71 IAI46_23670 uroporphyrinogen-III C-methyltransferase 0.81 IAI46_03340 3-isopropylmalate dehydratase small subunit low > 86
Erwinia tracheiphila SCR3 0.53 LU632_RS06420 cysG siroheme synthase CysG 0.72 LU632_RS02865 leuD 3-isopropylmalate dehydratase small subunit low > 74
Dickeya dianthicola 67-19 0.51 HGI48_RS17000 uroporphyrinogen-III C-methyltransferase 0.82 HGI48_RS18070 3-isopropylmalate dehydratase small subunit 0.68 63
Dickeya dadantii 3937 0.51 DDA3937_RS16930 uroporphyrinogen-III C-methyltransferase 0.83 DDA3937_RS18130 3-isopropylmalate dehydratase small subunit low > 74
Pseudomonas stutzeri RCH2 0.51 Psest_2037 uroporphyrin-III C-methyltransferase 0.62 Psest_2590 3-isopropylmalate dehydratase, small subunit 0.22 54
Dickeya dianthicola ME23 0.50 DZA65_RS18075 uroporphyrinogen-III C-methyltransferase 0.83 DZA65_RS19215 3-isopropylmalate dehydratase small subunit 0.72 44
Pantoea sp. MT58 0.50 IAI47_04175 uroporphyrinogen-III C-methyltransferase 0.79 IAI47_16015 3-isopropylmalate dehydratase small subunit 0.85 19
Pseudomonas syringae pv. syringae B728a ΔmexB 0.49 Psyr_3174 uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase 0.60 Psyr_1984 3-isopropylmalate dehydratase, small subunit 0.58 29
Pseudomonas syringae pv. syringae B728a 0.49 Psyr_3174 uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase 0.60 Psyr_1984 3-isopropylmalate dehydratase, small subunit 0.78 17
Pseudomonas sp. RS175 0.49 PFR28_02603 Siroheme synthase 0.64 PFR28_02823 3-isopropylmalate dehydratase small subunit 1 0.51 28
Pseudomonas fluorescens FW300-N1B4 0.49 Pf1N1B4_4065 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.63 Pf1N1B4_14 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) — —
Pseudomonas fluorescens FW300-N2C3 0.49 AO356_22200 sirohydrochlorin ferrochelatase 0.62 AO356_21405 3-isopropylmalate dehydratase 0.84 19
Pseudomonas fluorescens FW300-N2E2 0.49 Pf6N2E2_302 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.63 Pf6N2E2_64 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.77 16
Pseudomonas fluorescens GW456-L13 0.49 PfGW456L13_2656 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.64 PfGW456L13_3947 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) 0.95 7
Kangiella aquimarina DSM 16071 0.49 B158DRAFT_2163 uroporphyrin-III C-methyltransferase 0.57 B158DRAFT_1320 3-isopropylmalate dehydratase, small subunit low > 40
Pseudomonas fluorescens FW300-N2E3 0.49 AO353_27625 sirohydrochlorin ferrochelatase 0.64 AO353_20625 3-isopropylmalate dehydratase — —
Pseudomonas simiae WCS417 0.48 PS417_16465 sirohydrochlorin ferrochelatase 0.62 PS417_18595 3-isopropylmalate dehydratase 0.78 24
Pseudomonas fluorescens SBW25 0.48 PFLU_RS18505 uroporphyrinogen-III C-methyltransferase 0.63 PFLU_RS20575 3-isopropylmalate dehydratase small subunit low > 109
Pseudomonas fluorescens SBW25-INTG 0.48 PFLU_RS18505 uroporphyrinogen-III C-methyltransferase 0.63 PFLU_RS20575 3-isopropylmalate dehydratase small subunit 0.43 43
Pseudomonas putida KT2440 0.47 PP_3999 Uroporphyrinogen-III C-methyltransferase/Precorrin-2 dehydrogenase/Sirohydrochlorin ferrochelatase 0.63 PP_1986 3-isopropylmalate dehydratase small subunit 0.77 22
Acinetobacter radioresistens SK82 0.45 MPMX26_00706 Siroheme synthase 0.55 MPMX26_00346 3-isopropylmalate dehydratase small subunit 1 — —
Pseudomonas sp. S08-1 0.45 OH686_00285 Precorrin-2 oxidase or Sirohydrochlorin ferrochelatase activity of CysG / Uroporphyrinogen-III methyltransferase 0.63 OH686_04475 3-isopropylmalate dehydratase small subunit low > 80
Alteromonas macleodii MIT1002 0.45 MIT1002_00665 Siroheme synthase 0.60 MIT1002_00946 3-isopropylmalate dehydratase small subunit 1 — —
Dyella japonica UNC79MFTsu3.2 0.44 ABZR86_RS05880 siroheme synthase CysG 0.40 ABZR86_RS15955 3-isopropylmalate dehydratase small subunit 0.84 56
Lysobacter sp. OAE881 0.43 ABIE51_RS15855 siroheme synthase CysG 0.39 ABIE51_RS17580 3-isopropylmalate dehydratase small subunit 0.88 56
Castellaniella sp019104865 MT123 0.40 ABCV34_RS00210 siroheme synthase CysG 0.54 ABCV34_RS04285 3-isopropylmalate dehydratase small subunit low > 48
Rhodanobacter denitrificans FW104-10B01 0.38 LRK54_RS00910 siroheme synthase CysG 0.46 LRK54_RS07370 3-isopropylmalate dehydratase small subunit low > 59
Rhodanobacter denitrificans MT42 0.37 LRK55_RS00685 siroheme synthase CysG 0.46 LRK55_RS07100 3-isopropylmalate dehydratase small subunit 0.53 53
Agrobacterium fabrum C58 0.33 Atu3899 siroheme synthase 0.49 Atu2790 3-isopropylmalate dehydratase, small subunit low > 89
Sinorhizobium meliloti 1021 0.32 SMc01053 siroheme synthase 0.49 SMc03795 isopropylmalate isomerase small subunit 0.91 30
Brevundimonas sp. GW460-12-10-14-LB2 0.31 A4249_RS09675 siroheme synthase CysG 0.37 A4249_RS10000 3-isopropylmalate dehydratase small subunit 0.98 43
Rhizobium sp. OAE497 0.31 ABIE40_RS09140 siroheme synthase CysG 0.48 ABIE40_RS19040 3-isopropylmalate dehydratase small subunit 0.93 9
Rhodopseudomonas palustris CGA009 0.30 TX73_021850 siroheme synthase CysG 0.50 TX73_001215 3-isopropylmalate dehydratase small subunit — —
Rhodospirillum rubrum S1H 0.27 Rru_A1933 Uroporphyrin-III C-methyltransferase (NCBI) 0.48 Rru_A1190 3-isopropylmalate dehydratase small subunit region (NCBI) low > 58
Dinoroseobacter shibae DFL-12 0.27 Dshi_1155 uroporphyrin-III C-methyltransferase (RefSeq) 0.50 Dshi_0083 3-isopropylmalate dehydratase, small subunit (RefSeq) — —
Bosea sp. OAE506 0.26 ABIE41_RS15910 siroheme synthase CysG 0.46 ABIE41_RS11640 3-isopropylmalate dehydratase small subunit — —
Mycobacterium tuberculosis H37Rv 0.20 Rv2847c Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase 0.37 Rv2987c Probable 3-isopropylmalate dehydratase (small subunit) LeuD (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI) — —

Not shown: 1 genomes with orthologs for b3368 only; 42 genomes with orthologs for b0071 only