| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Methanococcus maripaludis S2 | MMP_RS06315 | | cobalt-precorrin-7 (C(5))-methyltransferase | sig. | 100 | 100 |
| o | Methanococcus maripaludis JJ | MMJJ_RS08035 | | cobalt-precorrin-7 (C(5))-methyltransferase | strong | 92 | 100 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF4640 | | Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) | insig. | 25 | 83 |
| o | Klebsiella michiganensis M5al | BWI76_RS23070 | | cobalt-precorrin-7 (C(5))-methyltransferase | strong | 28 | 100 |
| o | Fusobacterium nucleatum SB010 | HUW76_05290 | | precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE | cofit | 30 | 94 |
| o | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF3954 | | Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) | sig. | 26 | 100 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS15745 | | bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase | no data | 24 | 100 |
| o | Cupriavidus basilensis FW507-4G11 | RR42_RS30545 | | cobalt-precorrin-6Y C(5)-methyltransferase | sig. | 24 | 88 |
| o | Ralstonia solanacearum PSI07 | RPSI07_RS02240 | | cobalt-precorrin-7 (C(5))-methyltransferase | insig. | 23 | 88 |
| o | Ralstonia solanacearum IBSBF1503 | RALBFv3_RS20500 | | cobalt-precorrin-7 (C(5))-methyltransferase | insig. | 23 | 88 |
| o | Ralstonia solanacearum UW163 | UW163_RS18675 | | cobalt-precorrin-7 (C(5))-methyltransferase | insig. | 23 | 88 |
| o | Herbaspirillum seropedicae SmR1 | HSERO_RS13300 | | cobalt-precorrin-6Y C(5)-methyltransferase | sig. | 22 | 100 |
| o | Ralstonia solanacearum GMI1000 | RS_RS20105 | | cobalt-precorrin-7 (C(5))-methyltransferase | insig. | 23 | 88 |
| o | Klebsiella pneumoniae MKP103 | KDGMDA_03635 | | cobalt-precorrin-7 (C(5))-methyltransferase | insig. | 24 | 100 |
| | Azospirillum brasilense Sp245 | AZOBR_RS16710 | | precorrin-6Y C5 15-methyltransferase | insig. | 24 | 89 |
| | Rhodospirillum rubrum S1H | Rru_A2992 | | Precorrin-6Y C5,15-methyltransferase (decarboxylating) (NCBI) | cofit | 24 | 89 |
| | Dinoroseobacter shibae DFL-12 | Dshi_0173 | | precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit (RefSeq) | no data | 23 | 88 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS07435 | | precorrin-3B C(17)-methyltransferase | strong | 30 | 54 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_1175 | | precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit (RefSeq) | strong | 24 | 80 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF4634 | | Cobalt-precorrin-3b C17-methyltransferase | insig. | 29 | 54 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS01505 | | bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase | no data | 23 | 89 |
| | Methanococcus maripaludis S2 | MMP_RS08560 | | precorrin-4 C(11)-methyltransferase | no data | 26 | 92 |
| | Bacteroides stercoris CC31F | HMPREF1181_RS10585 | | precorrin-4 C(11)-methyltransferase | strong | 25 | 94 |
| | Methanococcus maripaludis JJ | MMJJ_RS05810 | | precorrin-4 C(11)-methyltransferase | strong | 26 | 92 |
| | Sinorhizobium meliloti 1021 | SMc03188 | | precorrin-6Y C5,15-methyltransferase (decarboxylating) protein | no data | 22 | 99 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU2749 | cobL | precorrin-6Y C5,15-methyltransferase (decarboxylating) (TIGR) | strong | 22 | 77 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS15515 | | precorrin-4 C(11)-methyltransferase | strong | 24 | 94 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS01550 | | precorrin-4 C(11)-methyltransferase | strong | 24 | 94 |
| | Rhizobium sp. OAE497 | ABIE40_RS20435 | | precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE | cofit | 23 | 98 |
| | Rhodopseudomonas palustris CGA009 | TX73_010750 | | bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase | strong | 24 | 89 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU0646 | cobI | precorrin-2 C20-methyltransferase (TIGR) | strong | 26 | 72 |
| | Marinobacter adhaerens HP15 | HP15_1815 | | siroheme synthase | strong | 22 | 94 |
| | Pseudomonas sp. RS175 | PFR28_02603 | | Siroheme synthase | strong | 23 | 94 |
| | Pseudomonas fluorescens FW300-N2E2 | Pf6N2E2_302 | | Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) | strong | 23 | 94 |
| | Pseudomonas simiae WCS417 | PS417_16465 | | sirohydrochlorin ferrochelatase | strong | 24 | 94 |
| | Pseudomonas fluorescens SBW25 | PFLU_RS18505 | | uroporphyrinogen-III C-methyltransferase | strong | 24 | 94 |
| | Pseudomonas fluorescens SBW25-INTG | PFLU_RS18505 | | uroporphyrinogen-III C-methyltransferase | strong | 24 | 94 |
| | Pseudomonas sp. S08-1 | OH686_00285 | | Precorrin-2 oxidase or Sirohydrochlorin ferrochelatase activity of CysG / Uroporphyrinogen-III methyltransferase | strong | 23 | 93 |
| | Paraburkholderia sabiae LMG 24235 | QEN71_RS25230 | | uroporphyrinogen-III C-methyltransferase | sig. | 22 | 97 |
| | Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS01540 | | precorrin-3B C(17)-methyltransferase | strong | 26 | 53 |
| | Dechlorosoma suillum PS | Dsui_2967 | | precorrin-3B C17-methyltransferase | cofit | 25 | 54 |
| | Agrobacterium fabrum C58 | Atu3899 | | siroheme synthase | insig. | 22 | 93 |
| | Phocaeicola dorei CL03T12C01 | ABI39_RS15525 | | precorrin-3B C(17)-methyltransferase | strong | 26 | 53 |
| | Agrobacterium fabrum C58 | Atu2798 | | precorrin-6y methyltransferase | strong | 23 | 88 |
| | Fusobacterium nucleatum SB010 | HUW76_05335 | | precorrin-4 C(11)-methyltransferase | strong | 23 | 93 |
| | Kangiella aquimarina DSM 16071 | B158DRAFT_2163 | | uroporphyrin-III C-methyltransferase | insig. | 24 | 98 |
| | Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_1902 | | uroporphyrin-III C-methyltransferase | insig. | 23 | 92 |
| | Fusobacterium nucleatum SB010 | HUW76_05380 | | precorrin-3B C(17)-methyltransferase | strong | 24 | 54 |
| | Klebsiella pneumoniae MKP103 | KDGMDA_03615 | | precorrin-3B C(17)-methyltransferase | insig. | 24 | 53 |
| | Parabacteroides merdae CL09T00C40 | HMPREF1078_RS07445 | | precorrin-4 C(11)-methyltransferase | strong | 24 | 93 |
| | Fusobacterium nucleatum SB010 | HUW76_06215 | | uroporphyrinogen-III C-methyltransferase | cofit | 26 | 94 |
| | Klebsiella michiganensis M5al | BWI76_RS23050 | | cobalt-precorrin-3B C(17)-methyltransferase | insig. | 22 | 55 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF3958 | | Cobalt-precorrin-3b C17-methyltransferase | cofit | 22 | 55 |
| | Azospirillum sp. SherDot2 | MPMX19_05567 | | Precorrin-6Y C(5,15)-methyltransferase [decarboxylating] | no data | 23 | 88 |
| | Methanococcus maripaludis JJ | MMJJ_RS00195 | | precorrin-3B C(17)-methyltransferase | strong | 25 | 55 |
| | Methanococcus maripaludis S2 | MMP_RS04940 | | precorrin-3B C(17)-methyltransferase | no data | 25 | 55 |
| | Methanococcus maripaludis JJ | MMJJ_RS03670 | | precorrin-2 C(20)-methyltransferase | strong | 29 | 54 |