Conservation of cofitness between Rv3133c and Rv2124c in Mycobacterium tuberculosis H37Rv

51 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Mycobacterium tuberculosis H37Rv 1.0 Rv3133c Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family) 1.0 Rv2124c 5-methyltetrahydrofolate--homocystein methyltransferase MetH (methionine synthase, vitamin-B12 dependent isozyme) (ms) 0.26 7
Kangiella aquimarina DSM 16071 0.32 B158DRAFT_1737 two component transcriptional regulator, LuxR family 0.24 B158DRAFT_2466 methionine synthase (B12-dependent) (EC 2.1.1.13) low > 40
Pseudomonas fluorescens FW300-N2E2 0.31 Pf6N2E2_1128 Two-component response regulator 0.22 Pf6N2E2_2068 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) low > 103
Pseudomonas lactucae CFBP13502 0.30 GEMAOFIL_03209 Transcriptional regulatory protein LnrK 0.22 GEMAOFIL_02709 Methionine synthase low > 96
Pseudomonas fluorescens SBW25 0.30 PFLU_RS14300 response regulator transcription factor 0.22 PFLU_RS13000 methionine synthase — —
Pseudomonas fluorescens SBW25-INTG 0.30 PFLU_RS14300 response regulator transcription factor 0.22 PFLU_RS13000 methionine synthase 0.20 4
Pseudomonas fluorescens FW300-N2C3 0.30 AO356_26265 LuxR family transcriptional regulator 0.22 AO356_00545 methionine synthase — —
Pseudomonas fluorescens FW300-N1B4 0.30 Pf1N1B4_5052 Two-component response regulator 0.22 Pf1N1B4_5661 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) — —
Methylophilus sp. DMC18 0.30 GFF606 Nitrate/nitrite response regulator protein NarL 0.22 GFF2281 Methionine synthase low > 43
Pseudomonas syringae pv. syringae B728a 0.30 Psyr_1940 regulatory protein, LuxR:Response regulator receiver 0.22 Psyr_2464 methionine synthase (B12-dependent) — —
Pseudomonas sp. RS175 0.30 PFR28_01868 Transcriptional regulatory protein DegU 0.22 PFR28_01369 Methionine synthase — —
Pseudomonas syringae pv. syringae B728a ΔmexB 0.30 Psyr_1940 regulatory protein, LuxR:Response regulator receiver 0.22 Psyr_2464 methionine synthase (B12-dependent) — —
Herbaspirillum seropedicae SmR1 0.30 HSERO_RS12850 LuxR family transcriptional regulator 0.23 HSERO_RS21740 methionine synthase low > 78
Rhodopseudomonas palustris CGA009 0.29 TX73_007655 response regulator transcription factor 0.23 TX73_019180 methionine synthase low > 86
Rhizobium sp. OAE497 0.28 ABIE40_RS27605 response regulator transcription factor 0.22 ABIE40_RS12135 methionine synthase 0.37 101
Shewanella sp. ANA-3 0.28 Shewana3_1152 two component LuxR family transcriptional regulator (RefSeq) 0.22 Shewana3_3282 metH B12-dependent methionine synthase (RefSeq) low > 73
Magnetospirillum magneticum AMB-1 0.27 AMB_RS18540 DNA-binding response regulator 0.43 AMB_RS02225 methionine synthase — —
Vibrio cholerae E7946 ATCC 55056 0.27 CSW01_06455 DNA-binding response regulator 0.23 CSW01_02060 methionine synthase low > 62
Dechlorosoma suillum PS 0.27 Dsui_3469 response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain 0.23 Dsui_0779 5-methyltetrahydrofolate--homocysteine methyltransferase — —
Sinorhizobium meliloti 1021 0.26 SM_b21520 two-component response regulator protein 0.22 SMc03112 B12-dependent methionine synthase low > 103
Castellaniella sp019104865 MT123 0.26 ABCV34_RS08970 response regulator transcription factor 0.23 ABCV34_RS14560 methionine synthase low > 48
Pseudomonas fluorescens FW300-N2E3 0.26 AO353_24485 regulator 0.22 AO353_21615 methionine synthase low > 101
Pseudomonas stutzeri RCH2 0.26 Psest_2048 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain 0.23 Psest_2102 5-methyltetrahydrofolate--homocysteine methyltransferase low > 67
Shewanella oneidensis MR-1 0.26 SO3982 narP DNA-binding nitrate/nitrite response regulator (NCBI ptt file) 0.21 SO1030 metH 5-methyltetrahydrofolate--homocysteine methyltransferase (NCBI ptt file) low > 76
Pseudomonas putida KT2440 0.26 PP_1090 putative Virulence factors positive transcription regulator BvgA 0.21 PP_2375 cobalamin-dependent methionine synthase low > 96
Pseudomonas sp. BP01 0.26 JOY50_RS23985 response regulator transcription factor 0.21 JOY50_RS10720 metH methionine synthase low > 84
Pectobacterium carotovorum WPP14 0.26 HER17_RS14245 response regulator transcription factor 0.22 HER17_RS02310 methionine synthase low > 75
Pontibacter actiniarum KMM 6156, DSM 19842 0.25 CA264_09180 DNA-binding response regulator 0.23 CA264_16785 methionine synthase low > 74
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.24 GFF3581 Secretion system regulator of DegU/UvrY/BvgA type 0.22 GFF1358 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) low > 78
Acinetobacter baumannii LAC-4 0.24 RR41_RS17790 response regulator 0.23 RR41_RS08790 methionine synthase low > 55
Azospirillum sp. SherDot2 0.24 MPMX19_01247 Transcriptional regulatory protein DegU 0.44 MPMX19_00637 Methionine synthase — —
Shewanella amazonensis SB2B 0.24 Sama_0646 response regulator receiver protein (RefSeq) 0.22 Sama_0758 metH B12-dependent methionine synthase (RefSeq) low > 62
Escherichia coli ECRC102 0.24 NIAGMN_06760 citB DNA-binding response regulator 0.22 NIAGMN_10990 metH methionine synthase low > 80
Escherichia coli ECRC99 0.24 KEDOAH_19265 citB DNA-binding response regulator 0.22 KEDOAH_14920 metH methionine synthase — —
Escherichia coli ECRC101 0.24 MCAODC_27935 citB DNA-binding response regulator 0.22 MCAODC_03740 metH methionine synthase low > 87
Escherichia coli ECRC98 0.24 JDDGAC_12360 citB DNA-binding response regulator 0.22 JDDGAC_16865 metH methionine synthase low > 87
Escherichia coli ECRC100 0.24 OKFHMN_08705 citB DNA-binding response regulator 0.22 OKFHMN_13240 metH methionine synthase low > 79
Pseudomonas sp. DMC3 0.24 GFF5090 Virulence factors putative positive transcription regulator BvgA 0.22 GFF3687 Methionine synthase low > 89
Escherichia coli BL21 0.24 ECD_03553 response regulator in two-component regulatory system wtih UhpB 0.22 ECD_03891 homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent low > 61
Escherichia coli ECOR27 0.24 NOLOHH_07335 uhpA_G97D DNA-binding response regulator UhpA 0.22 NOLOHH_05380 metH methionine synthase low > 76
Escherichia coli ECOR38 0.24 HEPCGN_13905 uhpA_G97D DNA-binding response regulator UhpA 0.22 HEPCGN_11885 metH methionine synthase low > 88
Klebsiella michiganensis M5al 0.24 BWI76_RS06060 DNA-binding response regulator 0.23 BWI76_RS01685 methionine synthase low > 92
Escherichia coli ECRC62 0.24 BNILDI_04190 uhpA_G97D DNA-binding response regulator UhpA 0.22 BNILDI_06140 metH methionine synthase low > 75
Escherichia coli HS(pFamp)R (ATCC 700891) 0.24 OHPLBJKB_00031 Transcriptional regulatory protein UhpA 0.22 OHPLBJKB_04030 Methionine synthase low > 74
Escherichia fergusonii Becca 0.24 EFB2_00029 Transcriptional regulatory protein UhpA 0.22 EFB2_04592 Methionine synthase low > 86
Escherichia coli BW25113 0.24 b3669 uhpA DNA-binding response regulator in two-component regulatory system wtih UhpB (NCBI) 0.22 b4019 metH B12-dependent methionine synthase (NCBI) low > 76
Escherichia coli Nissle 1917 0.24 ECOLIN_RS21160 transcriptional regulator UhpA 0.22 ECOLIN_RS23160 methionine synthase low > 55
Acinetobacter radioresistens SK82 0.23 MPMX26_00164 Response regulator GacA 0.23 MPMX26_02351 Methionine synthase low > 36
Mucilaginibacter yixingensis YX-36 DSM 26809 0.23 ABZR88_RS16950 response regulator transcription factor 0.23 ABZR88_RS20930 methionine synthase low > 71
Klebsiella pneumoniae MKP103 0.23 KDGMDA_08505 transcriptional regulator UhpA 0.22 KDGMDA_10165 methionine synthase low > 95
Enterobacter sp. TBS_079 0.23 MPMX20_00033 Transcriptional regulatory protein UhpA 0.22 MPMX20_00235 Methionine synthase low > 85
Enterobacter asburiae PDN3 0.22 EX28DRAFT_3952 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain 0.22 EX28DRAFT_4326 methionine synthase (B12-dependent) (EC 2.1.1.13) low > 76

Not shown: 26 genomes with orthologs for Rv3133c only; 24 genomes with orthologs for Rv2124c only