Conservation of cofitness between PP_4700 and PP_3999 in Pseudomonas putida KT2440

55 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Pseudomonas putida KT2440 1.0 PP_4700 pantothenate synthetase 1.0 PP_3999 Uroporphyrinogen-III C-methyltransferase/Precorrin-2 dehydrogenase/Sirohydrochlorin ferrochelatase 0.64 1
Pseudomonas sp. RS175 0.84 PFR28_03722 Pantothenate synthetase 0.84 PFR28_02603 Siroheme synthase — —
Pseudomonas fluorescens FW300-N2C3 0.83 AO356_16055 pantoate--beta-alanine ligase 0.84 AO356_22200 sirohydrochlorin ferrochelatase — —
Pseudomonas fluorescens FW300-N2E2 0.83 Pf6N2E2_5152 Pantoate--beta-alanine ligase (EC 6.3.2.1) 0.84 Pf6N2E2_302 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) — —
Pseudomonas fluorescens FW300-N2E3 0.83 AO353_14380 pantoate--beta-alanine ligase 0.84 AO353_27625 sirohydrochlorin ferrochelatase — —
Pseudomonas fluorescens GW456-L13 0.82 PfGW456L13_1520 Pantoate--beta-alanine ligase (EC 6.3.2.1) 0.84 PfGW456L13_2656 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) low > 87
Pseudomonas fluorescens FW300-N1B4 0.81 Pf1N1B4_2853 Pantoate--beta-alanine ligase (EC 6.3.2.1) 0.83 Pf1N1B4_4065 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) low > 87
Pseudomonas fluorescens SBW25 0.80 PFLU_RS25755 pantoate--beta-alanine ligase 0.84 PFLU_RS18505 uroporphyrinogen-III C-methyltransferase low > 109
Pseudomonas simiae WCS417 0.80 PS417_23915 pantoate--beta-alanine ligase 0.83 PS417_16465 sirohydrochlorin ferrochelatase low > 88
Pseudomonas fluorescens SBW25-INTG 0.80 PFLU_RS25755 pantoate--beta-alanine ligase 0.84 PFLU_RS18505 uroporphyrinogen-III C-methyltransferase 0.39 36
Pseudomonas sp. S08-1 0.78 OH686_17240 pantoate--beta-alanine ligase 0.77 OH686_00285 Precorrin-2 oxidase or Sirohydrochlorin ferrochelatase activity of CysG / Uroporphyrinogen-III methyltransferase — —
Pseudomonas syringae pv. syringae B728a 0.78 Psyr_0827 pantothenate synthetase 0.82 Psyr_3174 uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase 0.78 12
Pseudomonas syringae pv. syringae B728a ΔmexB 0.78 Psyr_0827 pantothenate synthetase 0.82 Psyr_3174 uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase 0.51 81
Pseudomonas stutzeri RCH2 0.71 Psest_0995 pantoate--beta-alanine ligase 0.77 Psest_2037 uroporphyrin-III C-methyltransferase — —
Alteromonas macleodii MIT1002 0.54 MIT1002_03695 Pantothenate synthetase 0.52 MIT1002_00665 Siroheme synthase — —
Serratia liquefaciens MT49 0.53 IAI46_21245 pantoate--beta-alanine ligase 0.48 IAI46_23670 uroporphyrinogen-III C-methyltransferase low > 86
Escherichia fergusonii Becca 0.53 EFB2_03911 Pantothenate synthetase 0.48 EFB2_00454 Siroheme synthase low > 86
Escherichia coli ECOR38 0.52 HEPCGN_08380 panC pantoate--beta-alanine ligase 0.48 HEPCGN_16010 cysG siroheme synthase CysG low > 85
Escherichia coli ECRC102 0.52 NIAGMN_08255 panC pantoate--beta-alanine ligase 0.48 NIAGMN_14950 cysG siroheme synthase CysG — —
Escherichia coli ECRC98 0.52 JDDGAC_14000 panC pantoate--beta-alanine ligase 0.48 JDDGAC_20810 cysG siroheme synthase CysG — —
Escherichia coli ECRC101 0.52 MCAODC_00920 panC pantoate--beta-alanine ligase 0.48 MCAODC_07710 cysG siroheme synthase CysG — —
Escherichia coli ECRC101 0.52 OKFHMN_10405 panC pantoate--beta-alanine ligase 0.48 OKFHMN_17180 cysG siroheme synthase CysG — —
Escherichia coli ECRC99 0.52 KEDOAH_17750 panC pantoate--beta-alanine ligase 0.48 KEDOAH_10960 cysG siroheme synthase CysG — —
Escherichia coli BW25113 0.52 b0133 panC pantoate--beta-alanine ligase (NCBI) 0.49 b3368 cysG fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) 0.34 61
Escherichia coli ECRC62 0.52 BNILDI_08920 panC pantoate--beta-alanine ligase 0.49 BNILDI_02540 cysG siroheme synthase CysG — —
Escherichia coli BL21 0.52 ECD_00132 pantothenate synthetase 0.49 ECD_03219 fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase low > 60
Escherichia coli HS(pFamp)R (ATCC 700891) 0.52 OHPLBJKB_03528 Pantothenate synthetase 0.49 OHPLBJKB_00334 Siroheme synthase low > 73
Escherichia coli ECOR27 0.52 NOLOHH_02750 panC pantoate--beta-alanine ligase 0.49 NOLOHH_08980 cysG siroheme synthase CysG low > 57
Kangiella aquimarina DSM 16071 0.51 B158DRAFT_0062 pantoate--beta-alanine ligase 0.43 B158DRAFT_2163 uroporphyrin-III C-methyltransferase — —
Pectobacterium carotovorum WPP14 0.51 HER17_RS05555 pantoate--beta-alanine ligase 0.48 HER17_RS01835 siroheme synthase CysG low > 75
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.51 GFF92 Pantoate--beta-alanine ligase (EC 6.3.2.1) 0.48 GFF3700 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) low > 78
Dickeya dianthicola ME23 0.51 DZA65_RS17160 pantoate--beta-alanine ligase 0.45 DZA65_RS18075 uroporphyrinogen-III C-methyltransferase 0.76 42
Dyella japonica UNC79MFTsu3.2 0.51 ABZR86_RS00820 pantoate--beta-alanine ligase 0.42 ABZR86_RS05880 siroheme synthase CysG — —
Dickeya dadantii 3937 0.51 DDA3937_RS15960 pantoate--beta-alanine ligase 0.46 DDA3937_RS16930 uroporphyrinogen-III C-methyltransferase 0.92 7
Klebsiella michiganensis M5al 0.51 BWI76_RS04990 pantoate--beta-alanine ligase 0.48 BWI76_RS26055 siroheme synthase low > 92
Erwinia tracheiphila SCR3 0.50 LU632_RS20105 panC pantoate--beta-alanine ligase 0.49 LU632_RS06420 cysG siroheme synthase CysG 0.82 8
Rhodanobacter denitrificans MT42 0.50 LRK55_RS14835 pantoate--beta-alanine ligase 0.36 LRK55_RS00685 siroheme synthase CysG low > 63
Dickeya dianthicola 67-19 0.50 HGI48_RS16075 pantoate--beta-alanine ligase 0.46 HGI48_RS17000 uroporphyrinogen-III C-methyltransferase low > 71
Rhodanobacter denitrificans FW104-10B01 0.50 LRK54_RS15120 pantoate--beta-alanine ligase 0.37 LRK54_RS00910 siroheme synthase CysG — —
Pantoea sp. MT58 0.50 IAI47_15660 pantoate--beta-alanine ligase 0.47 IAI47_04175 uroporphyrinogen-III C-methyltransferase low > 76
Rahnella sp. WP5 0.49 EX31_RS03285 pantoate--beta-alanine ligase 0.47 EX31_RS04680 uroporphyrinogen-III C-methyltransferase low > 89
Acinetobacter radioresistens SK82 0.49 MPMX26_00546 Pantothenate synthetase 0.55 MPMX26_00706 Siroheme synthase — —
Rhodanobacter sp. FW510-T8 0.49 OKGIIK_03890 panC pantoate--beta-alanine ligase 0.38 OKGIIK_05980 cysG siroheme synthase CysG low > 52
Enterobacter asburiae PDN3 0.48 EX28DRAFT_3729 pantoate--beta-alanine ligase 0.50 EX28DRAFT_4160 uroporphyrin-III C-methyltransferase low > 76
Enterobacter sp. TBS_079 0.47 MPMX20_00826 Pantothenate synthetase 0.50 MPMX20_04271 Siroheme synthase 0.23 27
Rhodospirillum rubrum S1H 0.46 Rru_A3320 Cytidyltransferase-related (NCBI) 0.30 Rru_A1933 Uroporphyrin-III C-methyltransferase (NCBI) — —
Lysobacter sp. OAE881 0.46 ABIE51_RS08030 pantoate--beta-alanine ligase 0.40 ABIE51_RS15855 siroheme synthase CysG — —
Sinorhizobium meliloti 1021 0.44 SMc01880 pantoate--beta-alanine ligase 0.34 SMc01053 siroheme synthase 0.64 45
Dinoroseobacter shibae DFL-12 0.43 Dshi_2952 pantoate--beta-alanine ligase (RefSeq) 0.28 Dshi_1671 uroporphyrin-III C-methyltransferase (RefSeq) — —
Agrobacterium fabrum C58 0.43 Atu3482 pantoate--beta-alanine ligase 0.33 Atu1454 siroheme synthase 0.85 25
Brevundimonas sp. GW460-12-10-14-LB2 0.43 A4249_RS06825 pantoate--beta-alanine ligase 0.36 A4249_RS09675 siroheme synthase CysG — —
Bosea sp. OAE506 0.43 ABIE41_RS14875 pantoate--beta-alanine ligase 0.30 ABIE41_RS15910 siroheme synthase CysG — —
Rhizobium sp. OAE497 0.42 ABIE40_RS09460 pantoate--beta-alanine ligase 0.33 ABIE40_RS09140 siroheme synthase CysG low > 107
Castellaniella sp019104865 MT123 0.41 ABCV34_RS14585 pantoate--beta-alanine ligase 0.37 ABCV34_RS00210 siroheme synthase CysG — —
Rhodopseudomonas palustris CGA009 0.40 TX73_016310 pantoate--beta-alanine ligase 0.35 TX73_021850 siroheme synthase CysG — —
Mycobacterium tuberculosis H37Rv 0.33 Rv3602c Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.20 Rv2847c Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase — —

Not shown: 42 genomes with orthologs for PP_4700 only; 1 genomes with orthologs for PP_3999 only