Conservation of cofitness between HEPCGN_02880 and HEPCGN_26930 in Escherichia coli ECOR38

57 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli ECOR38 1.0 HEPCGN_02880 mdtC multidrug efflux RND transporter permease subunit MdtC 1.0 HEPCGN_26930 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG 0.60 13
Escherichia coli ECOR27 0.99 NOLOHH_15535 mdtC multidrug efflux RND transporter permease subunit MdtC 1.00 NOLOHH_18640 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG — —
Escherichia coli ECRC62 0.99 BNILDI_14450 mdtC multidrug efflux RND transporter permease subunit MdtC 1.00 BNILDI_17130 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 75
Escherichia coli BL21 0.99 ECD_01981 multidrug efflux system, subunit C 1.00 ECD_01498 NADP-dependent 3-hydroxy acid dehydrogenase; malonic semialdehyde reductase low > 61
Escherichia coli ECRC101 0.99 MCAODC_20750 mdtC multidrug efflux RND transporter permease subunit MdtC 1.00 MCAODC_16910 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 87
Escherichia coli ECRC102 0.99 NIAGMN_22135 mdtC multidrug efflux RND transporter permease subunit MdtC 1.00 NIAGMN_25160 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG — —
Escherichia coli ECRC100 0.99 OKFHMN_24190 mdtC multidrug efflux RND transporter permease subunit MdtC 1.00 OKFHMN_01015 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 80
Escherichia coli ECRC98 0.99 JDDGAC_28300 mdtC multidrug efflux RND transporter permease subunit MdtC 1.00 JDDGAC_03525 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 86
Escherichia coli ECRC99 0.99 KEDOAH_03960 mdtC multidrug efflux RND transporter permease subunit MdtC 1.00 KEDOAH_27415 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG — —
Escherichia coli Nissle 1917 0.99 ECOLIN_RS12205 multidrug efflux RND transporter permease subunit MdtC 0.99 ECOLIN_RS08810 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG — —
Escherichia coli BW25113 0.99 b2076 mdtC multidrug efflux system, subunit C (NCBI) 1.00 b1539 ydfG L-allo-threonine dehydrogenase, NAD(P)-binding (NCBI) low > 76
Escherichia coli HS(pFamp)R (ATCC 700891) 0.99 OHPLBJKB_01628 Multidrug resistance protein MdtC 0.99 OHPLBJKB_02173 NADP-dependent 3-hydroxy acid dehydrogenase YdfG low > 73
Escherichia fergusonii Becca 0.99 EFB2_01779 Multidrug resistance protein MdtC 0.99 EFB2_02417 NADP-dependent 3-hydroxy acid dehydrogenase YdfG low > 86
Enterobacter asburiae PDN3 0.92 EX28DRAFT_0482 Cation/multidrug efflux pump 0.89 EX28DRAFT_1450 Short-chain alcohol dehydrogenase of unknown specificity low > 76
Enterobacter sp. TBS_079 0.91 MPMX20_03062 Multidrug resistance protein MdtC 0.89 MPMX20_02099 NADP-dependent 3-hydroxy acid dehydrogenase YdfG low > 85
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.90 GFF3853 Multidrug transporter MdtC 0.90 GFF2497 3-hydroxypropionate dehydrogenase (EC 1.1.1.298) low > 78
Klebsiella michiganensis M5al 0.90 BWI76_RS19260 multidrug transporter subunit MdtC 0.89 BWI76_RS15475 NAD(P)-dependent oxidoreductase low > 92
Serratia liquefaciens MT49 0.82 IAI46_18980 multidrug efflux RND transporter permease subunit MdtC 0.78 IAI46_11720 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 86
Pectobacterium carotovorum WPP14 0.79 HER17_RS06315 multidrug efflux RND transporter permease subunit MdtC 0.80 HER17_RS10705 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 75
Pantoea sp. MT58 0.79 IAI47_06865 multidrug efflux RND transporter permease subunit MdtC 0.83 IAI47_09805 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 76
Dickeya dianthicola 67-19 0.78 HGI48_RS15350 multidrug efflux RND transporter permease subunit MdtC 0.76 HGI48_RS10690 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 71
Dickeya dadantii 3937 0.78 DDA3937_RS15270 multidrug efflux RND transporter permease subunit MdtC 0.77 DDA3937_RS10695 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 74
Dickeya dianthicola ME23 0.78 DZA65_RS16170 multidrug efflux RND transporter permease subunit MdtC 0.76 DZA65_RS11160 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 75
Erwinia tracheiphila SCR3 0.73 LU632_RS08685 mdtC multidrug efflux RND transporter permease subunit MdtC 0.79 LU632_RS11720 ydfG bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 74
Ralstonia solanacearum PSI07 0.63 RPSI07_RS05520 nodulation protein 0.63 RPSI07_RS20325 NAD(P)-dependent oxidoreductase low > 81
Ralstonia solanacearum GMI1000 0.63 RS_RS22920 nodulation protein 0.64 RS_RS03675 NAD(P)-dependent oxidoreductase low > 80
Ralstonia solanacearum IBSBF1503 0.63 RALBFv3_RS18115 nodulation protein 0.64 RALBFv3_RS12900 NAD(P)-dependent oxidoreductase low > 76
Ralstonia solanacearum UW163 0.63 UW163_RS21015 nodulation protein 0.64 UW163_RS00665 NAD(P)-dependent oxidoreductase — —
Ralstonia sp. UNC404CL21Col 0.62 ABZR87_RS19020 multidrug efflux RND transporter permease subunit 0.66 ABZR87_RS08960 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 80
Herbaspirillum seropedicae SmR1 0.61 HSERO_RS07655 nodulation protein 0.63 HSERO_RS06135 malonic semialdehyde reductase low > 78
Pseudomonas fluorescens FW300-N2E3 0.55 AO353_22900 acriflavine resistance protein B 0.52 AO353_13380 hypothetical protein low > 101
Pseudomonas sp. S08-1 0.55 OH686_00930 Multidrug efflux system MdtABC-TolC, inner-membrane proton/drug antiporter MdtC (RND type) 0.21 OH686_18360 Short-chain dehydrogenase/reductase SDR low > 80
Pseudomonas fluorescens GW456-L13 0.54 PfGW456L13_3265 Acriflavin resistance plasma membrane protein 0.52 PfGW456L13_117 Oxidoreductase, short chain dehydrogenase/reductase family low > 87
Pseudomonas syringae pv. syringae B728a ΔmexB 0.53 Psyr_2484 Acriflavin resistance protein 0.53 Psyr_0602 Short-chain dehydrogenase/reductase SDR low > 86
Pseudomonas syringae pv. syringae B728a 0.53 Psyr_2484 Acriflavin resistance protein 0.53 Psyr_0602 Short-chain dehydrogenase/reductase SDR 0.25 53
Pseudomonas stutzeri RCH2 0.53 Psest_2140 Cation/multidrug efflux pump 0.52 Psest_0101 Short-chain alcohol dehydrogenase of unknown specificity low > 67
Pseudomonas fluorescens SBW25 0.53 PFLU_RS13435 MMPL family transporter 0.49 PFLU_RS02750 SDR family oxidoreductase low > 109
Pseudomonas fluorescens SBW25-INTG 0.53 PFLU_RS13435 MMPL family transporter 0.49 PFLU_RS02750 SDR family oxidoreductase low > 109
Rahnella sp. WP5 0.53 EX31_RS13375 MMPL family transporter 0.79 EX31_RS07075 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 89
Pseudomonas putida KT2440 0.52 PP_3583 multidrug efflux transport system - membrane subunit 0.52 PP_4862 3-hydroxy acid dehydrogenase, NADP-dependent / malonic semialdehyde reductase low > 96
Pseudomonas simiae WCS417 0.52 PS417_12750 acriflavine resistance protein B 0.49 PS417_02680 hypothetical protein low > 88
Castellaniella sp019104865 MT123 0.52 ABCV34_RS14625 efflux RND transporter permease subunit 0.57 ABCV34_RS03925 SDR family NAD(P)-dependent oxidoreductase low > 48
Pseudomonas fluorescens FW300-N2E2 0.52 Pf6N2E2_1271 Acriflavin resistance plasma membrane protein 0.52 Pf6N2E2_3575 Oxidoreductase, short chain dehydrogenase/reductase family low > 103
Pseudomonas fluorescens FW300-N2C3 0.51 AO356_25880 acriflavine resistance protein B 0.52 AO356_08475 hypothetical protein low > 104
Pseudomonas sp. RS175 0.51 PFR28_02193 Multidrug resistance protein MdtC 0.52 PFR28_05158 Sulfoacetaldehyde reductase low > 88
Paraburkholderia sabiae LMG 24235 0.47 QEN71_RS29845 efflux RND transporter permease subunit 0.72 QEN71_RS26240 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG low > 153
Paraburkholderia bryophila 376MFSha3.1 0.45 H281DRAFT_06491 multidrug efflux pump 0.71 H281DRAFT_04724 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase low > 103
Burkholderia phytofirmans PsJN 0.44 BPHYT_RS07780 nodulation protein 0.71 BPHYT_RS03720 malonic semialdehyde reductase low > 109
Desulfovibrio vulgaris Hildenborough JW710 0.43 DVU0438 AcrB/AcrD/AcrF family protein (TIGR) 0.61 DVU1784 oxidoreductase, short-chain dehydrogenase/reductase family (TIGR) low > 55
Desulfovibrio vulgaris Miyazaki F 0.43 DvMF_1515 acriflavin resistance protein (RefSeq) 0.53 DvMF_0398 short-chain dehydrogenase/reductase SDR (RefSeq) low > 51
Bosea sp. OAE506 0.41 ABIE41_RS20140 efflux RND transporter permease subunit 0.48 ABIE41_RS08870 SDR family NAD(P)-dependent oxidoreductase low > 77
Agrobacterium fabrum C58 0.39 Atu3274 AcrB/AcrD/AcrF family protein 0.50 Atu4110 serine dehydrogenase low > 89
Variovorax sp. OAS795 0.39 ABID97_RS06490 efflux RND transporter permease subunit 0.28 ABID97_RS05845 SDR family oxidoreductase low > 91
Rhizobium sp. OAE497 0.38 ABIE40_RS05760 efflux RND transporter permease subunit 0.22 ABIE40_RS03905 SDR family oxidoreductase low > 107
Pontibacter actiniarum KMM 6156, DSM 19842 0.24 CA264_13040 acriflavin resistance protein 0.44 CA264_00460 NAD(P)-dependent oxidoreductase low > 74
Acinetobacter radioresistens SK82 0.23 MPMX26_02516 Multidrug resistance protein MdtC 0.26 MPMX26_00858 putative oxidoreductase low > 36
Sinorhizobium meliloti 1021 0.23 SMc01457 transport transmembrane protein 0.27 SMa0320 short chain alcohol dehydrogenase-related dehydrogenase low > 103
Fusobacterium nucleatum SB010 0.16 HUW76_07660 efflux RND transporter permease subunit 0.34 HUW76_08120 SDR family NAD(P)-dependent oxidoreductase low > 35

Not shown: 6 genomes with orthologs for HEPCGN_02880 only; 29 genomes with orthologs for HEPCGN_26930 only