Conservation of cofitness between BNILDI_14450 and BNILDI_22420 in Escherichia coli ECRC62

56 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli ECRC62 1.0 BNILDI_14450 mdtC multidrug efflux RND transporter permease subunit MdtC 1.0 BNILDI_22420 cueR Cu(I)-responsive transcriptional regulator 0.74 3
Escherichia coli ECOR27 1.00 NOLOHH_15535 mdtC multidrug efflux RND transporter permease subunit MdtC 1.00 NOLOHH_01000 cueR Cu(I)-responsive transcriptional regulator low > 75
Escherichia coli BL21 1.00 ECD_01981 multidrug efflux system, subunit C 1.00 ECD_00438 copper-responsive regulon transcriptional regulator low > 61
Escherichia coli ECRC101 1.00 MCAODC_20750 mdtC multidrug efflux RND transporter permease subunit MdtC 0.99 MCAODC_27250 cueR Cu(I)-responsive transcriptional regulator low > 87
Escherichia coli ECRC100 1.00 OKFHMN_24190 mdtC multidrug efflux RND transporter permease subunit MdtC 0.99 OKFHMN_08035 cueR Cu(I)-responsive transcriptional regulator low > 80
Escherichia coli ECRC102 1.00 NIAGMN_22135 mdtC multidrug efflux RND transporter permease subunit MdtC 0.99 NIAGMN_06085 cueR Cu(I)-responsive transcriptional regulator — —
Escherichia coli ECRC99 1.00 KEDOAH_03960 mdtC multidrug efflux RND transporter permease subunit MdtC 0.99 KEDOAH_19935 cueR Cu(I)-responsive transcriptional regulator — —
Escherichia coli ECRC98 1.00 JDDGAC_28300 mdtC multidrug efflux RND transporter permease subunit MdtC 0.99 JDDGAC_11680 cueR Cu(I)-responsive transcriptional regulator low > 86
Escherichia coli BW25113 1.00 b2076 mdtC multidrug efflux system, subunit C (NCBI) 1.00 b0487 cueR DNA-binding transcriptional activator of copper-responsive regulon genes (NCBI) low > 76
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_01628 Multidrug resistance protein MdtC 1.00 OHPLBJKB_03187 HTH-type transcriptional regulator CueR low > 73
Escherichia coli ECOR38 0.99 HEPCGN_02880 mdtC multidrug efflux RND transporter permease subunit MdtC 0.96 HEPCGN_06670 cueR Cu(I)-responsive transcriptional regulator low > 87
Escherichia coli Nissle 1917 0.99 ECOLIN_RS12205 multidrug efflux RND transporter permease subunit MdtC 0.99 ECOLIN_RS02880 Cu(I)-responsive transcriptional regulator — —
Escherichia fergusonii Becca 0.99 EFB2_01779 Multidrug resistance protein MdtC 0.98 EFB2_03572 HTH-type transcriptional regulator CueR low > 86
Enterobacter asburiae PDN3 0.92 EX28DRAFT_0482 Cation/multidrug efflux pump 0.86 EX28DRAFT_2473 Cu(I)-responsive transcriptional regulator low > 76
Enterobacter sp. TBS_079 0.91 MPMX20_03062 Multidrug resistance protein MdtC 0.88 MPMX20_01085 HTH-type transcriptional regulator CueR low > 85
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.90 GFF3853 Multidrug transporter MdtC 0.93 GFF4405 HTH-type transcriptional regulator cueR low > 78
Klebsiella michiganensis M5al 0.90 BWI76_RS19260 multidrug transporter subunit MdtC 0.86 BWI76_RS06910 transcriptional regulator low > 92
Serratia liquefaciens MT49 0.82 IAI46_18980 multidrug efflux RND transporter permease subunit MdtC 0.77 IAI46_05315 Cu(I)-responsive transcriptional regulator low > 86
Pectobacterium carotovorum WPP14 0.79 HER17_RS06315 multidrug efflux RND transporter permease subunit MdtC 0.70 HER17_RS15620 Cu(I)-responsive transcriptional regulator low > 75
Pantoea sp. MT58 0.79 IAI47_06865 multidrug efflux RND transporter permease subunit MdtC 0.75 IAI47_14395 Cu(I)-responsive transcriptional regulator low > 76
Dickeya dianthicola 67-19 0.78 HGI48_RS15350 multidrug efflux RND transporter permease subunit MdtC 0.73 HGI48_RS05895 Cu(I)-responsive transcriptional regulator low > 71
Dickeya dadantii 3937 0.78 DDA3937_RS15270 multidrug efflux RND transporter permease subunit MdtC 0.73 DDA3937_RS05850 Cu(I)-responsive transcriptional regulator low > 74
Dickeya dianthicola ME23 0.78 DZA65_RS16170 multidrug efflux RND transporter permease subunit MdtC 0.73 DZA65_RS06230 Cu(I)-responsive transcriptional regulator low > 75
Erwinia tracheiphila SCR3 0.73 LU632_RS08685 mdtC multidrug efflux RND transporter permease subunit MdtC 0.66 LU632_RS15290 cueR Cu(I)-responsive transcriptional regulator low > 74
Ralstonia solanacearum PSI07 0.63 RPSI07_RS05520 nodulation protein 0.45 RPSI07_RS08315 Cu(I)-responsive transcriptional regulator low > 81
Ralstonia solanacearum GMI1000 0.63 RS_RS22920 nodulation protein 0.45 RS_RS16770 Cu(I)-responsive transcriptional regulator low > 80
Ralstonia solanacearum UW163 0.63 UW163_RS21015 nodulation protein 0.45 UW163_RS04655 Cu(I)-responsive transcriptional regulator — —
Ralstonia solanacearum IBSBF1503 0.63 RALBFv3_RS18115 nodulation protein 0.45 RALBFv3_RS08955 Cu(I)-responsive transcriptional regulator low > 76
Ralstonia sp. UNC404CL21Col 0.62 ABZR87_RS19020 multidrug efflux RND transporter permease subunit 0.46 ABZR87_RS04230 Cu(I)-responsive transcriptional regulator low > 80
Herbaspirillum seropedicae SmR1 0.62 HSERO_RS07655 nodulation protein 0.41 HSERO_RS08015 MerR family transcriptional regulator low > 78
Pseudomonas fluorescens FW300-N2E3 0.55 AO353_22900 acriflavine resistance protein B 0.41 AO353_06160 transcriptional regulator low > 101
Pseudomonas sp. S08-1 0.55 OH686_00930 Multidrug efflux system MdtABC-TolC, inner-membrane proton/drug antiporter MdtC (RND type) 0.43 OH686_07400 Cu(I)-responsive transcriptional regulator low > 80
Pseudomonas fluorescens GW456-L13 0.54 PfGW456L13_3265 Acriflavin resistance plasma membrane protein 0.42 PfGW456L13_25 Cu(I)-responsive transcriptional regulator low > 87
Pseudomonas syringae pv. syringae B728a ΔmexB 0.54 Psyr_2484 Acriflavin resistance protein 0.45 Psyr_0653 transcriptional regulator, MerR family low > 86
Pseudomonas syringae pv. syringae B728a 0.54 Psyr_2484 Acriflavin resistance protein 0.45 Psyr_0653 transcriptional regulator, MerR family low > 86
Pseudomonas fluorescens SBW25 0.53 PFLU_RS13435 MMPL family transporter 0.40 PFLU_RS03235 Cu(I)-responsive transcriptional regulator low > 109
Pseudomonas fluorescens SBW25-INTG 0.53 PFLU_RS13435 MMPL family transporter 0.40 PFLU_RS03235 Cu(I)-responsive transcriptional regulator low > 109
Pseudomonas stutzeri RCH2 0.53 Psest_2140 Cation/multidrug efflux pump 0.47 Psest_0737 Cu(I)-responsive transcriptional regulator low > 67
Rahnella sp. WP5 0.53 EX31_RS13375 MMPL family transporter 0.77 EX31_RS22580 Cu(I)-responsive transcriptional regulator low > 89
Pseudomonas simiae WCS417 0.53 PS417_12750 acriflavine resistance protein B 0.41 PS417_03155 transcriptional regulator low > 88
Pseudomonas putida KT2440 0.53 PP_3583 multidrug efflux transport system - membrane subunit 0.47 PP_0585 putative metal-sensitive transcriptional regulator, MerR family low > 96
Castellaniella sp019104865 MT123 0.52 ABCV34_RS14625 efflux RND transporter permease subunit 0.41 ABCV34_RS04205 Cu(I)-responsive transcriptional regulator low > 48
Pseudomonas fluorescens FW300-N2E2 0.52 Pf6N2E2_1271 Acriflavin resistance plasma membrane protein 0.41 Pf6N2E2_3488 Cu(I)-responsive transcriptional regulator low > 103
Pseudomonas fluorescens FW300-N2C3 0.52 AO356_25880 acriflavine resistance protein B 0.41 AO356_08070 transcriptional regulator low > 104
Pseudomonas sp. RS175 0.51 PFR28_02193 Multidrug resistance protein MdtC 0.42 PFR28_05243 HTH-type transcriptional regulator HmrR low > 88
Paraburkholderia sabiae LMG 24235 0.47 QEN71_RS29845 efflux RND transporter permease subunit 0.45 QEN71_RS23915 Cu(I)-responsive transcriptional regulator low > 153
Paraburkholderia bryophila 376MFSha3.1 0.44 H281DRAFT_06491 multidrug efflux pump 0.43 H281DRAFT_04982 transcriptional regulator, MerR family low > 103
Azospirillum brasilense Sp245 0.44 AZOBR_RS14670 multidrug transporter 0.43 AZOBR_RS19845 MerR family transcriptional regulator low > 97
Burkholderia phytofirmans PsJN 0.43 BPHYT_RS07780 nodulation protein 0.44 BPHYT_RS06865 MerR family transcriptional regulator low > 109
Bosea sp. OAE506 0.41 ABIE41_RS20140 efflux RND transporter permease subunit 0.41 ABIE41_RS15580 Cu(I)-responsive transcriptional regulator low > 77
Agrobacterium fabrum C58 0.39 Atu3274 AcrB/AcrD/AcrF family protein 0.37 Atu0938 transcriptional regulator, MerR family low > 89
Variovorax sp. OAS795 0.39 ABID97_RS06490 efflux RND transporter permease subunit 0.37 ABID97_RS02815 Cu(I)-responsive transcriptional regulator low > 91
Rhizobium sp. OAE497 0.39 ABIE40_RS05760 efflux RND transporter permease subunit 0.37 ABIE40_RS20305 Cu(I)-responsive transcriptional regulator low > 107
Acinetobacter radioresistens SK82 0.24 MPMX26_02516 Multidrug resistance protein MdtC 0.40 MPMX26_01947 HTH-type transcriptional regulator HmrR — —
Sinorhizobium meliloti 1021 0.23 SMc01457 transport transmembrane protein 0.44 SM_b21579 MerR family transcriptional regulator low > 103
Caulobacter crescentus NA1000 Δfur 0.20 CCNA_03301 cation/multidrug efflux pump AcrB 0.25 CCNA_03178 MerR-family transcriptional regulator low > 67
Caulobacter crescentus NA1000 0.20 CCNA_03301 cation/multidrug efflux pump AcrB 0.25 CCNA_03178 MerR-family transcriptional regulator low > 66

Not shown: 7 genomes with orthologs for BNILDI_14450 only; 16 genomes with orthologs for BNILDI_22420 only