| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_12845 | | metalloprotease PmbA | 1.0 | CSW01_10660 | | sigma-54-dependent Fis family transcriptional regulator | 0.85 | 19 |
| Serratia liquefaciens MT49 | 0.65 | IAI46_22575 | | metalloprotease PmbA | 0.31 | IAI46_19460 | | two-component system response regulator GlrR | low | > 86 |
| Escherichia coli ECRC101 | 0.64 | MCAODC_02430 | pmbA | metalloprotease PmbA | 0.30 | MCAODC_12025 | qseF | two-component system response regulator QseF/GlrR | low | > 88 |
| Escherichia coli ECRC100 | 0.64 | OKFHMN_11925 | pmbA | metalloprotease PmbA | 0.30 | OKFHMN_21495 | qseF | two-component system response regulator QseF/GlrR | low | > 79 |
| Escherichia coli ECRC98 | 0.64 | JDDGAC_15565 | pmbA | metalloprotease PmbA | 0.30 | JDDGAC_25160 | qseF | two-component system response regulator QseF/GlrR | low | > 87 |
| Escherichia coli ECRC102 | 0.64 | NIAGMN_09775 | pmbA | metalloprotease PmbA | 0.30 | NIAGMN_19265 | qseF | two-component system response regulator QseF/GlrR | low | > 80 |
| Escherichia coli ECRC62 | 0.64 | BNILDI_07325 | pmbA | metalloprotease PmbA | 0.30 | BNILDI_11970 | qseF | two-component system response regulator QseF/GlrR | low | > 75 |
| Escherichia coli ECRC99 | 0.64 | KEDOAH_16230 | pmbA | metalloprotease PmbA | 0.30 | KEDOAH_06725 | qseF | two-component system response regulator QseF/GlrR | — | — |
| Enterobacter asburiae PDN3 | 0.64 | EX28DRAFT_3422 | | Predicted Zn-dependent proteases and their inactivated homologs | 0.30 | EX28DRAFT_0096 | | Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains | low | > 76 |
| Enterobacter sp. TBS_079 | 0.64 | MPMX20_00517 | | Metalloprotease PmbA | 0.30 | MPMX20_03423 | | Transcriptional regulatory protein QseF | low | > 85 |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.64 | GFF904 | | TldE protein, part of TldE/TldD proteolytic complex | 0.31 | GFF2455 | | Putative sensory histidine kinase YfhA | low | > 78 |
| Klebsiella michiganensis M5al | 0.64 | BWI76_RS02850 | | metalloprotease PmbA | 0.31 | BWI76_RS21250 | | two-component system response regulator GlrR | low | > 92 |
| Shewanella oneidensis MR-1 | 0.58 | SO4078 | pmbA | pmba protein (NCBI ptt file) | 0.58 | SO3230 | flrC | flagellar regulatory protein C (NCBI ptt file) | low | > 76 |
| Shewanella sp. ANA-3 | 0.58 | Shewana3_3631 | | microcin-processing peptidase 1 (RefSeq) | 0.58 | Shewana3_1340 | | two component, sigma54 specific, Fis family transcriptional regulator (RefSeq) | low | > 73 |
| Shewanella amazonensis SB2B | 0.58 | Sama_0482 | | PmbA protein (RefSeq) | 0.58 | Sama_2299 | | response regulator receiver protein (RefSeq) | low | > 62 |
| Shewanella loihica PV-4 | 0.56 | Shew_0416 | | peptidase U62, modulator of DNA gyrase (RefSeq) | 0.58 | Shew_1364 | | two component, sigma54 specific, Fis family transcriptional regulator (RefSeq) | low | > 60 |
| Alteromonas macleodii MIT1002 | 0.54 | MIT1002_00230 | | peptidase PmbA | 0.61 | MIT1002_01083 | | Transcriptional regulatory protein ZraR | low | > 70 |
| Pseudomonas putida KT2440 | 0.49 | PP_0942 | | regulatory protease | 0.48 | PP_4371 | | two component system AtoC DNA-binding transcriptional activator | low | > 96 |
| Pseudomonas sp. BP01 | 0.48 | JOY50_RS11080 | pmbA | metalloprotease PmbA | 0.49 | JOY50_RS00695 | | sigma-54 dependent transcriptional regulator | low | > 84 |
| Pseudomonas sp. RS175 | 0.48 | PFR28_00163 | | Metalloprotease PmbA | 0.50 | PFR28_00830 | | Regulatory protein AtoC | low | > 88 |
| Pseudomonas fluorescens FW300-N2C3 | 0.48 | AO356_07085 | | peptidase PmbA | 0.48 | AO356_03845 | | Fis family transcriptional regulator | low | > 104 |
| Pseudomonas lactucae CFBP13502 | 0.48 | GEMAOFIL_01064 | | Metalloprotease PmbA | 0.49 | GEMAOFIL_04161 | | Regulatory protein AtoC | low | > 93 |
| Pseudomonas fluorescens SBW25-INTG | 0.48 | PFLU_RS04350 | | metalloprotease PmbA | 0.49 | PFLU_RS21785 | | sigma-54-dependent Fis family transcriptional regulator | low | > 109 |
| Pseudomonas fluorescens SBW25 | 0.48 | PFLU_RS04350 | | metalloprotease PmbA | 0.49 | PFLU_RS21785 | | sigma-54-dependent Fis family transcriptional regulator | low | > 109 |
| Pseudomonas fluorescens FW300-N2E2 | 0.48 | Pf6N2E2_3278 | | TldE protein, part of TldE/TldD proteolytic complex | 0.50 | Pf6N2E2_2595 | | Flagellar regulatory protein FleQ | low | > 103 |
| Pseudomonas fluorescens FW300-N2E3 | 0.47 | AO353_05205 | | peptidase PmbA | 0.50 | AO353_18670 | | Fis family transcriptional regulator | 0.30 | 67 |
| Pseudomonas sp. DMC3 | 0.47 | GFF1818 | | Metalloprotease PmbA | 0.50 | GFF2447 | | Regulatory protein AtoC | low | > 89 |
| Pseudomonas simiae WCS417 | 0.47 | PS417_04295 | | peptidase PmbA | 0.49 | PS417_19815 | | Fis family transcriptional regulator | — | — |
| Pseudomonas sp. SVBP6 | 0.47 | COO64_RS04235 | pmbA | metalloprotease PmbA | 0.48 | COO64_RS21290 | | sigma-54 dependent transcriptional regulator | low | > 93 |
| Pseudomonas syringae pv. syringae B728a | 0.47 | Psyr_4154 | | microcin-processing peptidase 1, Unknown type peptidase, MEROPS family U62 | 0.48 | Psyr_3459 | | Helix-turn-helix, Fis-type | low | > 86 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.47 | Psyr_4154 | | microcin-processing peptidase 1, Unknown type peptidase, MEROPS family U62 | 0.48 | Psyr_3459 | | Helix-turn-helix, Fis-type | low | > 86 |
| Pseudomonas sp. S08-1 | 0.47 | OH686_08570 | | TldE protein, part of TldE/TldD proteolytic complex | 0.51 | OH686_02845 | | Flagellar two-component response regulator FleR | low | > 80 |
| Pseudomonas aeruginosa PA14 | 0.47 | IKLFDK_01720 | | metalloprotease PmbA | 0.49 | IKLFDK_05055 | | sigma-54-dependent response regulator transcription factor FleR | low | > 100 |
| Pseudomonas fluorescens GW456-L13 | 0.47 | PfGW456L13_5024 | | TldE protein, part of TldE/TldD proteolytic complex | 0.49 | PfGW456L13_4355 | | Flagellar regulatory protein FleQ | low | > 87 |
| Pseudomonas stutzeri RCH2 | 0.46 | Psest_3318 | | Predicted Zn-dependent proteases and their inactivated homologs | 0.50 | Psest_1767 | | Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains | low | > 67 |
| Pseudomonas segetis P6 | 0.46 | MPMX49_03863 | | Metalloprotease PmbA | 0.51 | MPMX49_03148 | | Regulatory protein AtoC | low | > 75 |
| Dechlorosoma suillum PS | 0.44 | Dsui_1234 | | putative Zn-dependent protease-like protein | 0.45 | Dsui_1758 | | response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains | low | > 51 |
| Azospirillum brasilense Sp245 | 0.32 | AZOBR_RS11930 | | modulator protein | 0.30 | AZOBR_RS20165 | | ATPase AAA | low | > 97 |
| Rhodopseudomonas palustris CGA009 | 0.28 | TX73_005930 | | TldD/PmbA family protein | 0.30 | TX73_006510 | | sigma-54 dependent transcriptional regulator | 0.30 | 59 |
| Caulobacter crescentus NA1000 Δfur | 0.28 | CCNA_00311 | | Zn-dependent protease family protein | 0.31 | CCNA_00954 | | AAA-family response regulator flbD | low | > 67 |
| Caulobacter crescentus NA1000 | 0.28 | CCNA_00311 | | Zn-dependent protease family protein | 0.31 | CCNA_00954 | | AAA-family response regulator flbD | 0.71 | 27 |
| Magnetospirillum magneticum AMB-1 | 0.27 | AMB_RS22120 | | TldD/PmbA family protein | 0.32 | AMB_RS02570 | | sigma-54-dependent Fis family transcriptional regulator | low | > 64 |
| Rhodospirillum rubrum S1H | 0.25 | Rru_A0575 | | Peptidase U62, modulator of DNA gyrase (NCBI) | 0.31 | Rru_A0540 | | Two Component, Sigma54 Specific, Transcriptional Regulator, Fis family (NCBI) | low | > 58 |
| Brevundimonas sp. GW460-12-10-14-LB2 | 0.25 | A4249_RS09195 | | TldD/PmbA family protein | 0.30 | A4249_RS09765 | | sigma-54 dependent transcriptional regulator | low | > 48 |
| Pontibacter actiniarum KMM 6156, DSM 19842 | 0.06 | CA264_16645 | | peptidase C69 | 0.32 | CA264_09510 | | sigma-54-dependent Fis family transcriptional regulator | low | > 74 |
Not shown: 57 genomes with orthologs for CSW01_12845 only; 2 genomes with orthologs for CSW01_10660 only