| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_18635 | | phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating) | 1.0 | CSW01_04820 | | serine hydroxymethyltransferase | 0.87 | 20 |
| Echinicola vietnamensis KMM 6221, DSM 17526 | 0.65 | Echvi_4222 | | 6-phosphogluconate dehydrogenase, decarboxylating | 0.51 | Echvi_1188 | | Glycine/serine hydroxymethyltransferase | 0.37 | 45 |
| Parabacteroides merdae CL09T00C40 | 0.58 | HMPREF1078_RS08640 | | decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase | 0.53 | HMPREF1078_RS02145 | | serine hydroxymethyltransferase | low | > 61 |
| Bacteroides stercoris CC31F | 0.54 | HMPREF1181_RS12525 | | decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase | 0.53 | HMPREF1181_RS15010 | | serine hydroxymethyltransferase | low | > 56 |
| Paraburkholderia sabiae LMG 24235 | 0.53 | QEN71_RS20525 | | NADP-dependent phosphogluconate dehydrogenase | 0.70 | QEN71_RS33600 | | serine hydroxymethyltransferase | low | > 153 |
| Dickeya dianthicola ME23 | 0.53 | DZA65_RS07180 | | NADP-dependent phosphogluconate dehydrogenase | 0.81 | DZA65_RS16775 | | serine hydroxymethyltransferase | — | — |
| Escherichia coli ECRC62 | 0.52 | BNILDI_14695 | gndA | NADP-dependent phosphogluconate dehydrogenase | 0.79 | BNILDI_11985 | glyA | serine hydroxymethyltransferase | low | > 75 |
| Pectobacterium carotovorum WPP14 | 0.52 | HER17_RS14505 | | NADP-dependent phosphogluconate dehydrogenase | 0.81 | HER17_RS05950 | | serine hydroxymethyltransferase | — | — |
| Escherichia coli ECRC99 | 0.52 | KEDOAH_03680 | gndA | NADP-dependent phosphogluconate dehydrogenase | 0.79 | KEDOAH_06710 | glyA | serine hydroxymethyltransferase | — | — |
| Escherichia coli ECRC101 | 0.52 | MCAODC_20470 | gndA | NADP-dependent phosphogluconate dehydrogenase | 0.79 | MCAODC_12040 | glyA | serine hydroxymethyltransferase | — | — |
| Escherichia coli ECRC100 | 0.52 | OKFHMN_24470 | gndA | NADP-dependent phosphogluconate dehydrogenase | 0.79 | OKFHMN_21510 | glyA | serine hydroxymethyltransferase | low | > 79 |
| Escherichia coli ECRC98 | 0.52 | JDDGAC_28580 | gndA | NADP-dependent phosphogluconate dehydrogenase | 0.79 | JDDGAC_25175 | glyA | serine hydroxymethyltransferase | — | — |
| Escherichia coli ECRC102 | 0.52 | NIAGMN_22415 | gndA | NADP-dependent phosphogluconate dehydrogenase | 0.79 | NIAGMN_19280 | glyA | serine hydroxymethyltransferase | low | > 80 |
| Escherichia coli BW25113 | 0.52 | b2029 | gnd | 6-phosphogluconate dehydrogenase (NCBI) | 0.79 | b2551 | glyA | serine hydroxymethyltransferase (NCBI) | — | — |
| Escherichia coli ECOR27 | 0.52 | NOLOHH_15785 | gndA | NADP-dependent phosphogluconate dehydrogenase | 0.79 | NOLOHH_13185 | glyA | serine hydroxymethyltransferase | low | > 76 |
| Escherichia coli Nissle 1917 | 0.52 | ECOLIN_RS11990 | | NADP-dependent phosphogluconate dehydrogenase | 0.79 | ECOLIN_RS14440 | | serine hydroxymethyltransferase | — | — |
| Dickeya dadantii 3937 | 0.52 | DDA3937_RS06805 | | NADP-dependent phosphogluconate dehydrogenase | 0.81 | DDA3937_RS15600 | | serine hydroxymethyltransferase | — | — |
| Serratia liquefaciens MT49 | 0.52 | IAI46_08160 | | NADP-dependent phosphogluconate dehydrogenase | 0.81 | IAI46_19395 | | serine hydroxymethyltransferase | — | — |
| Escherichia coli BL21 | 0.52 | ECD_01931 | | 6-phosphogluconate dehydrogenase, decarboxylating | 0.79 | ECD_02443 | | serine hydroxymethyltransferase | low | > 61 |
| Klebsiella pneumoniae MKP103 | 0.52 | KDGMDA_26195 | | NADP-dependent phosphogluconate dehydrogenase | 0.79 | KDGMDA_28355 | | Serine hydroxymethyltransferase | low | > 95 |
| Escherichia coli ECOR38 | 0.52 | HEPCGN_03175 | gndA | NADP-dependent phosphogluconate dehydrogenase | 0.79 | HEPCGN_20655 | glyA | serine hydroxymethyltransferase | low | > 88 |
| Paraburkholderia bryophila 376MFSha3.1 | 0.52 | H281DRAFT_03046 | | 6-phosphogluconate dehydrogenase (decarboxylating) | 0.63 | H281DRAFT_04726 | | serine hydroxymethyltransferase | — | — |
| Escherichia fergusonii Becca | 0.52 | EFB2_01826 | | 6-phosphogluconate dehydrogenase, decarboxylating | 0.79 | EFB2_01345 | | Serine hydroxymethyltransferase | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.52 | OHPLBJKB_01659 | | 6-phosphogluconate dehydrogenase, decarboxylating | 0.79 | OHPLBJKB_01156 | | Serine hydroxymethyltransferase | low | > 74 |
| Rahnella sp. WP5 | 0.52 | EX31_RS11475 | | NADP-dependent phosphogluconate dehydrogenase | 0.80 | EX31_RS20585 | | serine hydroxymethyltransferase | — | — |
| Klebsiella michiganensis M5al | 0.52 | BWI76_RS19025 | | phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating) | 0.79 | BWI76_RS21225 | | serine hydroxymethyltransferase | — | — |
| Dickeya dianthicola 67-19 | 0.52 | HGI48_RS06840 | | NADP-dependent phosphogluconate dehydrogenase | 0.81 | HGI48_RS15700 | | serine hydroxymethyltransferase | — | — |
| Bacteroides ovatus ATCC 8483 | 0.52 | BACOVA_00509 | | phosphogluconate dehydrogenase (decarboxylating) | 0.53 | BACOVA_02446 | | glycine hydroxymethyltransferase | low | > 96 |
| Dyella japonica UNC79MFTsu3.2 | 0.52 | ABZR86_RS13330 | | NADP-dependent phosphogluconate dehydrogenase | 0.72 | ABZR86_RS10715 | | serine hydroxymethyltransferase | low | > 74 |
| Paraburkholderia graminis OAS925 | 0.51 | ABIE53_005122 | | 6-phosphogluconate dehydrogenase | 0.63 | ABIE53_000888 | | glycine hydroxymethyltransferase | — | — |
| Enterobacter sp. TBS_079 | 0.51 | MPMX20_03014 | | 6-phosphogluconate dehydrogenase, decarboxylating | 0.79 | MPMX20_03420 | | Serine hydroxymethyltransferase | — | — |
| Variovorax sp. OAS795 | 0.51 | ABID97_RS10190 | | decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase | 0.62 | ABID97_RS17890 | | serine hydroxymethyltransferase | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.51 | GFF3903 | | 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) | 0.79 | GFF2447 | | Serine hydroxymethyltransferase (EC 2.1.2.1) | — | — |
| Enterobacter asburiae PDN3 | 0.51 | EX28DRAFT_0529 | | 6-phosphogluconate dehydrogenase (decarboxylating) | 0.79 | EX28DRAFT_0099 | | Glycine/serine hydroxymethyltransferase | — | — |
| Variovorax sp. SCN45 | 0.51 | GFF2954 | | 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) | 0.62 | GFF560 | | Serine hydroxymethyltransferase (EC 2.1.2.1) | — | — |
| Phocaeicola dorei CL03T12C01 | 0.51 | ABI39_RS14350 | | decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase | 0.54 | ABI39_RS17420 | | serine hydroxymethyltransferase | low | > 72 |
| Bacteroides thetaiotaomicron VPI-5482 | 0.51 | BT1222 | | 6-phosphogluconate dehydrogenase,decarboxylating (NCBI ptt file) | 0.53 | BT0738 | | serine hydroxymethyltransferase (NCBI ptt file) | low | > 81 |
| Erwinia amylovora T8 | 0.51 | OLJFJH_12140 | | NADP-dependent phosphogluconate dehydrogenase | 0.79 | OLJFJH_10340 | | Serine hydroxymethyltransferase | — | — |
| Burkholderia phytofirmans PsJN | 0.50 | BPHYT_RS29625 | | 6-phosphogluconate dehydrogenase | 0.63 | BPHYT_RS03725 | | serine hydroxymethyltransferase | low | > 109 |
| Erwinia tracheiphila HP pepo 2.2 | 0.50 | IJEDHG_19020 | gndA | NADP-dependent phosphogluconate dehydrogenase | 0.80 | IJEDHG_02915 | | Serine hydroxymethyltransferase 1 | — | — |
| Pantoea sp. MT58 | 0.50 | IAI47_07035 | | NADP-dependent phosphogluconate dehydrogenase | 0.81 | IAI47_04960 | | serine hydroxymethyltransferase | — | — |
| Pantoea agglomerans CFBP13505 P0401 | 0.50 | PagCFBP13505_RS01160 | | NADP-dependent phosphogluconate dehydrogenase | 0.81 | PagCFBP13505_RS14850 | | serine hydroxymethyltransferase | — | — |
| Phocaeicola vulgatus CL09T03C04 | 0.50 | HMPREF1058_RS18025 | | decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase | 0.54 | HMPREF1058_RS03800 | | serine hydroxymethyltransferase | 0.37 | 33 |
| Erwinia tracheiphila SCR3 | 0.50 | LU632_RS08890 | gndA | NADP-dependent phosphogluconate dehydrogenase | 0.80 | LU632_RS17915 | | serine hydroxymethyltransferase | — | — |
| Methylophilus sp. DMC18 | 0.48 | GFF2795 | | 6-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating | 0.64 | GFF72 | | Serine hydroxymethyltransferase | — | — |
| Synechocystis sp000284455 PCC 6803 | 0.48 | SGL_RS12985 | | decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase | 0.57 | SGL_RS04690 | | serine hydroxymethyltransferase | — | — |
| Shewanella amazonensis SB2B | 0.43 | Sama_1365 | | 6-phosphogluconate dehydrogenase (RefSeq) | 0.82 | Sama_1014 | glyA | serine hydroxymethyltransferase (RefSeq) | low | > 62 |
| Alteromonas macleodii MIT1002 | 0.42 | MIT1002_02397 | | 6-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating | 0.73 | MIT1002_02702 | | Serine hydroxymethyltransferase | low | > 70 |
| Cellulophaga baltica 18 | 0.42 | M666_RS18130 | | NADP-dependent phosphogluconate dehydrogenase | 0.54 | M666_RS14985 | | serine hydroxymethyltransferase | — | — |
| Pedobacter sp. GW460-11-11-14-LB5 | 0.42 | CA265_RS09805 | | phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating) | 0.50 | CA265_RS19165 | | serine hydroxymethyltransferase | low | > 88 |
| Shewanella loihica PV-4 | 0.42 | Shew_2561 | | 6-phosphogluconate dehydrogenase (RefSeq) | 0.81 | Shew_1185 | glyA | serine hydroxymethyltransferase (RefSeq) | low | > 60 |
| Shewanella sp. ANA-3 | 0.42 | Shewana3_1677 | | 6-phosphogluconate dehydrogenase (RefSeq) | 0.83 | Shewana3_1094 | glyA | serine hydroxymethyltransferase (RefSeq) | low | > 73 |
| Shewanella oneidensis MR-1 | 0.40 | SO1902 | gnd | 6-phosphogluconate dehydrogenase, decarboxylating (NCBI ptt file) | 0.83 | SO3471 | glyA | serine hydroxymethyltransferase (NCBI ptt file) | low | > 76 |
Not shown: 8 genomes with orthologs for CSW01_18635 only; 44 genomes with orthologs for CSW01_04820 only