| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank | 
|---|
 | Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_10535 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 1.0 | CSW01_01280 |  | GDP-mannose 4,6-dehydratase | 0.75 | 13 | 
 | Rahnella sp. WP5 | 0.50 | EX31_RS19660 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.52 | EX31_RS02865 |  | GDP-mannose 4,6-dehydratase | low | > 89 | 
 | Dickeya dianthicola ME23 | 0.49 | DZA65_RS15420 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.87 | DZA65_RS19730 |  | GDP-mannose 4,6-dehydratase | low | > 75 | 
 | Escherichia coli ECOR27 | 0.49 | NOLOHH_14275 | mnmC | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.83 | NOLOHH_15675 |  | GDP-mannose 4,6-dehydratase | low | > 76 | 
 | Escherichia coli Nissle 1917 | 0.49 | ECOLIN_RS13465 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.82 | ECOLIN_RS12095 |  | GDP-mannose 4,6-dehydratase | low | > 55 | 
 | Escherichia fergusonii Becca | 0.49 | EFB2_01534 |  | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | 0.83 | EFB2_01801 |  | GDP-mannose 4,6-dehydratase | low | > 86 | 
 | Escherichia coli BW25113 | 0.49 | b2324 | b2324 | putative peptidase (VIMSS) | 0.83 | b2053 | gmd | GDP-D-mannose dehydratase, NAD(P)-binding (NCBI) | low | > 76 | 
 | Dickeya dianthicola 67-19 | 0.49 | HGI48_RS14485 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.87 | HGI48_RS18595 |  | GDP-mannose 4,6-dehydratase | low | > 71 | 
 | Escherichia coli HS(pFamp)R (ATCC 700891) | 0.49 | OHPLBJKB_01381 |  | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | 0.10 | OHPLBJKB_04266 |  | dTDP-glucose 4,6-dehydratase 2 | low | > 74 | 
 | Escherichia coli ECRC62 | 0.49 | BNILDI_13195 | mnmC | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.83 | BNILDI_14585 |  | GDP-mannose 4,6-dehydratase | low | > 75 | 
 | Pectobacterium carotovorum WPP14 | 0.49 | HER17_RS06960 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.78 | HER17_RS14540 |  | GDP-mannose 4,6-dehydratase | low | > 75 | 
 | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.49 | GFF1945 |  | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61) / FAD-dependent cmnm(5)s(2)U34 oxidoreductase | 0.83 | GFF3875 |  | GDP-mannose 4,6-dehydratase (EC 4.2.1.47) | low | > 78 | 
 | Escherichia coli BL21 | 0.49 | ECD_02249 |  | fused 5-methylaminomethyl-2-thiouridine-forming enzyme methyltransferase and FAD-dependent demodification enzyme | 0.83 | ECD_01959 |  | GDP-D-mannose dehydratase, NAD(P)-binding | low | > 61 | 
 | Escherichia coli ECOR38 | 0.49 | HEPCGN_21845 | mnmC | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.83 | HEPCGN_03045 |  | GDP-mannose 4,6-dehydratase | low | > 88 | 
 | Dickeya dadantii 3937 | 0.48 | DDA3937_RS14515 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.87 | DDA3937_RS18665 |  | GDP-mannose 4,6-dehydratase | low | > 74 | 
 | Escherichia coli ECRC100 | 0.48 | OKFHMN_22640 | mnmC | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.83 | OKFHMN_24440 |  | GDP-mannose 4,6-dehydratase | — | — | 
 | Escherichia coli ECRC99 | 0.48 | KEDOAH_05555 | mnmC | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.83 | KEDOAH_03710 |  | GDP-mannose 4,6-dehydratase | — | — | 
 | Escherichia coli ECRC101 | 0.48 | MCAODC_13680 | mnmC | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.83 | MCAODC_20500 |  | GDP-mannose 4,6-dehydratase | — | — | 
 | Escherichia coli ECRC98 | 0.48 | JDDGAC_26600 | mnmC | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.83 | JDDGAC_28550 |  | GDP-mannose 4,6-dehydratase | — | — | 
 | Enterobacter asburiae PDN3 | 0.48 | EX28DRAFT_0280 |  | tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain | 0.83 | EX28DRAFT_0502 |  | GDP-mannose 4,6-dehydratase | low | > 76 | 
 | Escherichia coli ECRC102 | 0.48 | NIAGMN_20415 | mnmC | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.83 | NIAGMN_22385 |  | GDP-mannose 4,6-dehydratase | low | > 80 | 
 | Enterobacter sp. TBS_079 | 0.48 | MPMX20_03259 |  | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | 0.82 | MPMX20_03035 |  | GDP-mannose 4,6-dehydratase | low | > 85 | 
 | Erwinia amylovora T8 | 0.47 | OLJFJH_11180 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.10 | OLJFJH_12090 |  | dTDP-glucose 4 6-dehydratase | — | — | 
 | Pantoea agglomerans CFBP13505 P0401 | 0.45 | PagCFBP13505_RS00130 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.46 | PagCFBP13505_RS01140 |  | GDP-mannose 4,6-dehydratase | low | > 74 | 
 | Pantoea sp. MT58 | 0.45 | IAI47_06175 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.11 | IAI47_18500 |  | dTDP-glucose 4,6-dehydratase | — | — | 
 | Pseudomonas stutzeri RCH2 | 0.29 | Psest_1634 |  | tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain | 0.83 | Psest_1818 |  | GDP-mannose 4,6-dehydratase | low | > 67 | 
 | Pseudomonas sp. DMC3 | 0.29 | GFF4698 |  | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | 0.40 | GFF545 |  | GDP-mannose 4,6-dehydratase | low | > 89 | 
 | Pseudomonas syringae pv. syringae B728a | 0.29 | Psyr_3742 |  | FAD dependent oxidoreductase:Protein of unknown function DUF752 | 0.45 | Psyr_0916 |  | GDP-mannose 4,6-dehydratase | low | > 86 | 
 | Pseudomonas syringae pv. syringae B728a ΔmexB | 0.29 | Psyr_3742 |  | FAD dependent oxidoreductase:Protein of unknown function DUF752 | 0.45 | Psyr_0916 |  | GDP-mannose 4,6-dehydratase | low | > 86 | 
 | Pseudomonas fluorescens GW456-L13 | 0.28 | PfGW456L13_2155 |  | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61) / FAD-dependent cmnm(5)s(2)U34 oxidoreductase | 0.40 | PfGW456L13_2338 |  | GDP-mannose 4,6-dehydratase (EC 4.2.1.47) | low | > 87 | 
 | Pseudomonas lactucae CFBP13502 | 0.28 | GEMAOFIL_02096 |  | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | 0.46 | GEMAOFIL_04278 |  | GDP-mannose 4,6-dehydratase | low | > 93 | 
 | Pseudomonas fluorescens FW300-N2E3 | 0.28 | AO353_02165 |  | FAD-dependent cmnm(5)s(2)U34 oxidoreductase | 0.42 | AO353_10245 |  | GDP-mannose 4,6-dehydratase | low | > 101 | 
 | Pseudomonas fluorescens FW300-N1B4 | 0.28 | Pf1N1B4_373 |  | 5-methylaminomethyl-2-thiouridine-forming enzyme mnmC | 0.39 | Pf1N1B4_1965 |  | GDP-mannose 4,6-dehydratase (EC 4.2.1.47) | low | > 87 | 
 | Pseudomonas aeruginosa PA14 | 0.28 | IKLFDK_17740 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.39 | IKLFDK_26150 |  | GDP-mannose 4 6-dehydratase | low | > 100 | 
 | Pseudomonas fluorescens FW300-N2C3 | 0.28 | AO356_03570 |  | FAD-dependent cmnm(5)s(2)U34 oxidoreductase | 0.40 | AO356_11835 |  | GDP-mannose 4,6-dehydratase | low | > 104 | 
 | Pseudomonas fluorescens FW300-N2E2 | 0.28 | Pf6N2E2_2541 |  | 5-methylaminomethyl-2-thiouridine-forming enzyme mnmC | 0.40 | Pf6N2E2_4242 |  | GDP-mannose 4,6-dehydratase (EC 4.2.1.47) | low | > 103 | 
 | Pseudomonas putida KT2440 | 0.28 | PP_1751 |  | methyltransferase/FAD-dependent oxidoreductase | 0.46 | PP_1799 |  | GDP-mannose 4,6-dehydratase | low | > 96 | 
 | Pseudomonas sp. SVBP6 | 0.28 | COO64_RS06835 | mnmC | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.45 | COO64_RS06615 | gmd | GDP-mannose 4,6-dehydratase | low | > 93 | 
 | Pseudomonas sp. RS175 | 0.28 | PFR28_00884 |  | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | 0.40 | PFR28_04554 |  | GDP-mannose 4,6-dehydratase | low | > 88 | 
 | Pseudomonas sp. S08-1 | 0.27 | OH686_20990 |  | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase / FAD-dependent cmnm(5)s(2)U34 oxidoreductase | 0.40 | OH686_11980 |  | GDP-mannose 4,6-dehydratase | low | > 80 | 
 | Pseudomonas segetis P6 | 0.27 | MPMX49_02868 |  | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | 0.43 | MPMX49_00388 |  | GDP-mannose 4,6-dehydratase | low | > 75 | 
 | Pseudomonas fluorescens SBW25 | 0.27 | PFLU_RS21190 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.77 | PFLU_RS17890 |  | GDP-mannose 4,6-dehydratase | low | > 109 | 
 | Pseudomonas fluorescens SBW25-INTG | 0.27 | PFLU_RS21190 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.77 | PFLU_RS17890 |  | GDP-mannose 4,6-dehydratase | low | > 109 | 
 | Paraburkholderia bryophila 376MFSha3.1 | 0.24 | H281DRAFT_02360 |  | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein | 0.69 | H281DRAFT_04776 |  | GDPmannose 4,6-dehydratase | low | > 103 | 
 | Paraburkholderia graminis OAS925 | 0.24 | ABIE53_000291 |  | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein | 0.68 | ABIE53_000940 |  | GDPmannose 4,6-dehydratase | low | > 113 | 
 | Dechlorosoma suillum PS | 0.24 | Dsui_2868 |  | tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain protein | 0.71 | Dsui_0085 |  | GDP-mannose 4,6-dehydratase | low | > 51 | 
 | Burkholderia phytofirmans PsJN | 0.23 | BPHYT_RS19575 |  | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | 0.69 | BPHYT_RS04000 |  | GDP-mannose 4,6-dehydratase | low | > 109 | 
 | Ralstonia solanacearum PSI07 | 0.22 | RPSI07_RS16115 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.47 | RPSI07_RS19840 |  | GDP-mannose 4,6-dehydratase | low | > 81 | 
 | Paraburkholderia sabiae LMG 24235 | 0.22 | QEN71_RS29485 |  | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.70 | QEN71_RS26360 |  | GDP-mannose 4,6-dehydratase | low | > 153 | 
 | Cupriavidus basilensis FW507-4G11 | 0.19 | RR42_RS09010 |  | FAD-dependent cmnm(5)s(2)U34 oxidoreductase | 0.76 | RR42_RS33235 |  | GDP-mannose 4,6-dehydratase | low | > 128 | 
 | Castellaniella sp019104865 MT123 | 0.16 | ABCV34_RS09580 |  | FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.71 | ABCV34_RS12935 |  | GDP-mannose 4,6-dehydratase | — | — | 
 | Brevundimonas sp. GW460-12-10-14-LB2 | 0.15 | A4249_RS15340 |  | tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD | 0.43 | A4249_RS12980 |  | GDP-mannose 4,6-dehydratase | low | > 48 | 
 | Variovorax sp. OAS795 | 0.15 | ABID97_RS15455 |  | FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | 0.44 | ABID97_RS05705 |  | GDP-mannose 4,6-dehydratase | 0.40 | 19 | 
 | Variovorax sp. SCN45 | 0.14 | GFF1245 |  | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61) / FAD-dependent cmnm(5)s(2)U34 oxidoreductase | 0.74 | GFF61 |  | GDP-mannose 4,6-dehydratase (EC 4.2.1.47) | low | > 127 | 
 | Caulobacter crescentus NA1000 | 0.13 | CCNA_00785 |  | tRNA methyltransferase/FAD-dependent oxidoreductase MnmC | 0.63 | CCNA_00472 |  | GDP-mannose 4,6 dehydratase | low | > 66 | 
 | Caulobacter crescentus NA1000 Δfur | 0.13 | CCNA_00785 |  | tRNA methyltransferase/FAD-dependent oxidoreductase MnmC | 0.63 | CCNA_00472 |  | GDP-mannose 4,6 dehydratase | low | > 67 | 
Not shown: 21 genomes with orthologs for CSW01_10535 only; 32 genomes with orthologs for CSW01_01280 only