Conservation of cofitness between BT3757 and BT1377 in Bacteroides thetaiotaomicron VPI-5482

47 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Bacteroides thetaiotaomicron VPI-5482 1.0 BT3757 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data) 1.0 BT1377 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (NCBI ptt file) 0.92 7
Bacteroides ovatus ATCC 8483 0.92 BACOVA_03587 pyrroline-5-carboxylate reductase 0.98 BACOVA_00218 phosphoribosyl-ATP diphosphatase 0.86 40
Bacteroides stercoris CC31F 0.78 HMPREF1181_RS03440 pyrroline-5-carboxylate reductase 0.88 HMPREF1181_RS11065 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.92 26
Phocaeicola vulgatus CL09T03C04 0.69 HMPREF1058_RS08830 pyrroline-5-carboxylate reductase 0.89 HMPREF1058_RS06180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.95 4
Phocaeicola dorei CL03T12C01 0.69 ABI39_RS02960 pyrroline-5-carboxylate reductase 0.89 ABI39_RS19935 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.82 16
Parabacteroides merdae CL09T00C40 0.51 HMPREF1078_RS10620 pyrroline-5-carboxylate reductase 0.76 HMPREF1078_RS13560 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.92 45
Mucilaginibacter yixingensis YX-36 DSM 26809 0.39 ABZR88_RS09865 pyrroline-5-carboxylate reductase 0.51 ABZR88_RS06845 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Echinicola vietnamensis KMM 6221, DSM 17526 0.34 Echvi_2479 pyrroline-5-carboxylate reductase 0.59 Echvi_2517 phosphoribosyl-ATP pyrophosphohydrolase 0.74 31
Pedobacter sp. GW460-11-11-14-LB5 0.34 CA265_RS18505 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data) 0.50 CA265_RS03605 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.93 24
Pontibacter actiniarum KMM 6156, DSM 19842 0.33 CA264_07730 pyrroline-5-carboxylate reductase 0.51 CA264_05115 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase low > 74
Escherichia coli ECOR27 0.24 NOLOHH_01535 proC pyrroline-5-carboxylate reductase 0.46 NOLOHH_15800 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 57
Escherichia fergusonii Becca 0.24 EFB2_03670 Pyrroline-5-carboxylate reductase 0.47 EFB2_01830 Histidine biosynthesis bifunctional protein HisIE low > 86
Escherichia coli BW25113 0.24 b0386 proC pyrroline-5-carboxylate reductase (NCBI) 0.50 b2026 hisI bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) 0.86 19
Escherichia coli ECRC62 0.24 BNILDI_22950 proC pyrroline-5-carboxylate reductase 0.50 BNILDI_14710 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli Nissle 1917 0.24 ECOLIN_RS02345 pyrroline-5-carboxylate reductase 0.47 ECOLIN_RS11975 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Synechococcus elongatus PCC 7942 0.24 Synpcc7942_2058 proC pyrroline-5-carboxylate reductase 0.34 Synpcc7942_1995 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein — —
Erwinia tracheiphila SCR3 0.24 LU632_RS18995 proC pyrroline-5-carboxylate reductase 0.44 LU632_RS08915 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.58 53
Escherichia coli HS(pFamp)R (ATCC 700891) 0.24 OHPLBJKB_03288 Pyrroline-5-carboxylate reductase 0.50 OHPLBJKB_01674 Histidine biosynthesis bifunctional protein HisIE low > 73
Escherichia coli BL21 0.24 ECD_00333 pyrroline-5-carboxylate reductase, NAD(P)-binding 0.50 ECD_01928 phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase low > 60
Escherichia coli ECOR38 0.24 HEPCGN_07250 proC pyrroline-5-carboxylate reductase 0.50 HEPCGN_03190 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 85
Escherichia coli ECRC101 0.24 OKFHMN_08610 proC pyrroline-5-carboxylate reductase 0.47 OKFHMN_24485 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC98 0.24 JDDGAC_12265 proC pyrroline-5-carboxylate reductase 0.47 JDDGAC_28595 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Klebsiella michiganensis M5al 0.24 BWI76_RS06170 pyrroline-5-carboxylate reductase 0.49 BWI76_RS18955 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase — —
Escherichia coli ECRC101 0.24 MCAODC_27835 proC pyrroline-5-carboxylate reductase 0.47 MCAODC_20455 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC99 0.24 KEDOAH_19355 proC pyrroline-5-carboxylate reductase 0.47 KEDOAH_03665 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC102 0.24 NIAGMN_06665 proC pyrroline-5-carboxylate reductase 0.47 NIAGMN_22430 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.24 GFF4283 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) 0.46 GFF3906 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) low > 78
Enterobacter asburiae PDN3 0.23 EX28DRAFT_2585 pyrroline-5-carboxylate reductase 0.48 EX28DRAFT_0533 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19)/phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.74 11
Enterobacter sp. TBS_079 0.23 MPMX20_00976 Pyrroline-5-carboxylate reductase 0.49 MPMX20_03008 Histidine biosynthesis bifunctional protein HisIE 0.86 30
Alteromonas macleodii MIT1002 0.23 MIT1002_03062 Pyrroline-5-carboxylate reductase 0.50 MIT1002_02639 Phosphoribosyl-ATP pyrophosphatase 0.93 46
Lysobacter sp. OAE881 0.22 ABIE51_RS16065 pyrroline-5-carboxylate reductase 0.45 ABIE51_RS13295 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 62
Pantoea sp. MT58 0.21 IAI47_14945 pyrroline-5-carboxylate reductase 0.48 IAI47_07060 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.83 28
Shewanella loihica PV-4 0.21 Shew_1136 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data) 0.48 Shew_2204 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.92 32
Shewanella oneidensis MR-1 0.20 SO3354 proC pyrroline-5-carboxylate reductase (NCBI ptt file) 0.51 SO2067 hisI phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase (NCBI ptt file) 0.94 36
Shewanella amazonensis SB2B 0.20 Sama_2478 pyrroline-5-carboxylate reductase (RefSeq) 0.49 Sama_1948 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.94 31
Vibrio cholerae E7946 ATCC 55056 0.20 CSW01_02450 pyrroline-5-carboxylate reductase 0.51 CSW01_05780 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase low > 62
Shewanella sp. ANA-3 0.19 Shewana3_1193 pyrroline-5-carboxylate reductase (RefSeq) 0.49 Shewana3_1847 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.91 37
Dyella japonica UNC79MFTsu3.2 0.19 ABZR86_RS10425 pyrroline-5-carboxylate reductase 0.51 ABZR86_RS06700 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.90 19
Serratia liquefaciens MT49 0.18 IAI46_21415 pyrroline-5-carboxylate reductase 0.45 IAI46_08180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 86
Dickeya dadantii 3937 0.18 DDA3937_RS17305 pyrroline-5-carboxylate reductase 0.47 DDA3937_RS09705 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.72 15
Dickeya dianthicola ME23 0.18 DZA65_RS18440 pyrroline-5-carboxylate reductase 0.46 DZA65_RS10025 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Dickeya dianthicola 67-19 0.18 HGI48_RS17350 pyrroline-5-carboxylate reductase 0.46 HGI48_RS09715 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Pectobacterium carotovorum WPP14 0.17 HER17_RS03805 pyrroline-5-carboxylate reductase 0.41 HER17_RS12260 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Rhodanobacter sp. FW510-T8 0.16 OKGIIK_11135 proC pyrroline-5-carboxylate reductase 0.51 OKGIIK_04980 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 52
Rhodanobacter denitrificans FW104-10B01 0.16 LRK54_RS04260 pyrroline-5-carboxylate reductase 0.49 LRK54_RS01575 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.73 22
Rhodanobacter denitrificans MT42 0.16 LRK55_RS04030 pyrroline-5-carboxylate reductase 0.50 LRK55_RS01355 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Rahnella sp. WP5 0.15 EX31_RS02690 pyrroline-5-carboxylate reductase 0.43 EX31_RS11470 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.95 37
Xanthomonas campestris pv. campestris strain 8004 0.14 Xcc-8004.1710.1 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) 0.49 Xcc-8004.2942.1 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.61 20

Not shown: 42 genomes with orthologs for BT3757 only; 2 genomes with orthologs for BT1377 only