Conservation of cofitness between b2026 and b3770 in Escherichia coli BW25113

49 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b2026 hisI bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) 1.0 b3770 ilvE branched-chain amino acid aminotransferase (NCBI) 0.96 2
Escherichia coli BL21 1.00 ECD_01928 phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase 1.00 ECD_03648 branched-chain amino acid aminotransferase low > 60
Escherichia coli ECRC101 0.99 MCAODC_20455 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 MCAODC_05150 ilvE branched-chain-amino-acid transaminase — —
Escherichia coli ECOR38 0.99 HEPCGN_03190 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 HEPCGN_13355 ilvE branched-chain-amino-acid transaminase low > 85
Escherichia coli ECRC99 0.99 KEDOAH_03665 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 KEDOAH_13505 ilvE branched-chain-amino-acid transaminase — —
Escherichia coli ECRC102 0.99 NIAGMN_22430 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 NIAGMN_12400 ilvE branched-chain-amino-acid transaminase — —
Escherichia coli ECRC98 0.99 JDDGAC_28595 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 JDDGAC_18265 ilvE branched-chain-amino-acid transaminase — —
Escherichia coli ECRC101 0.99 OKFHMN_24485 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 OKFHMN_14645 ilvE branched-chain-amino-acid transaminase — —
Escherichia coli Nissle 1917 0.99 ECOLIN_RS11975 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 ECOLIN_RS21660 branched-chain-amino-acid transaminase — —
Escherichia coli ECRC62 0.98 BNILDI_14710 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 BNILDI_04745 ilvE branched-chain-amino-acid transaminase — —
Escherichia fergusonii Becca 0.98 EFB2_01830 Histidine biosynthesis bifunctional protein HisIE 1.00 EFB2_04866 Branched-chain-amino-acid aminotransferase low > 86
Escherichia coli HS(pFamp)R (ATCC 700891) 0.96 OHPLBJKB_01674 Histidine biosynthesis bifunctional protein HisIE 1.00 OHPLBJKB_04283 Branched-chain-amino-acid aminotransferase low > 73
Escherichia coli ECOR27 0.92 NOLOHH_15800 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 NOLOHH_06780 ilvE branched-chain-amino-acid transaminase low > 57
Enterobacter sp. TBS_079 0.91 MPMX20_03008 Histidine biosynthesis bifunctional protein HisIE 0.99 MPMX20_04500 Branched-chain-amino-acid aminotransferase low > 85
Enterobacter asburiae PDN3 0.91 EX28DRAFT_0533 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19)/phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.98 EX28DRAFT_4442 branched-chain amino acid aminotransferase, group I 0.76 40
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.89 GFF3906 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.98 GFF2902 Branched-chain amino acid aminotransferase (EC 2.6.1.42) low > 78
Klebsiella michiganensis M5al 0.87 BWI76_RS18955 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.97 BWI76_RS00970 branched chain amino acid aminotransferase 0.53 81
Dickeya dadantii 3937 0.81 DDA3937_RS09705 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.91 DDA3937_RS20160 branched-chain-amino-acid transaminase 0.82 40
Pantoea sp. MT58 0.81 IAI47_07060 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.91 IAI47_01030 branched-chain amino acid transaminase 0.97 17
Dickeya dianthicola 67-19 0.80 HGI48_RS09715 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.90 HGI48_RS20300 branched-chain-amino-acid transaminase low > 71
Dickeya dianthicola ME23 0.80 DZA65_RS10025 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.91 DZA65_RS21340 branched-chain amino acid transaminase 0.68 54
Erwinia tracheiphila SCR3 0.76 LU632_RS08915 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.90 LU632_RS24405 branched-chain amino acid transaminase 0.70 69
Rahnella sp. WP5 0.76 EX31_RS11470 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.90 EX31_RS15000 branched-chain amino acid transaminase 0.90 53
Serratia liquefaciens MT49 0.76 IAI46_08180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.92 IAI46_24350 branched-chain-amino-acid transaminase low > 86
Pectobacterium carotovorum WPP14 0.70 HER17_RS12260 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.90 HER17_RS01070 branched-chain amino acid transaminase 0.87 69
Vibrio cholerae E7946 ATCC 55056 0.64 CSW01_05780 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.75 CSW01_00145 branched-chain-amino-acid transaminase low > 62
Alteromonas macleodii MIT1002 0.63 MIT1002_02639 Phosphoribosyl-ATP pyrophosphatase 0.17 MIT1002_00377 Branched-chain-amino-acid aminotransferase 2 0.94 28
Shewanella oneidensis MR-1 0.62 SO2067 hisI phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase (NCBI ptt file) 0.19 SO0340 ilvE branched-chain amino acid aminotransferase (NCBI ptt file) 0.85 61
Shewanella amazonensis SB2B 0.61 Sama_1948 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.19 Sama_3299 branched-chain amino acid aminotransferase (RefSeq) low > 62
Shewanella sp. ANA-3 0.60 Shewana3_1847 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.19 Shewana3_3830 branched-chain amino acid aminotransferase (RefSeq) low > 73
Shewanella loihica PV-4 0.57 Shew_2204 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.68 Shew_0291 branched-chain amino acid aminotransferase (RefSeq) 0.91 44
Rhodanobacter denitrificans MT42 0.56 LRK55_RS01355 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.56 LRK55_RS11755 branched-chain amino acid transaminase low > 63
Rhodanobacter denitrificans FW104-10B01 0.55 LRK54_RS01575 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.56 LRK54_RS12020 branched-chain amino acid transaminase low > 59
Rhodanobacter sp. FW510-T8 0.55 OKGIIK_04980 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.56 OKGIIK_11840 ilvE branched-chain amino acid transaminase low > 52
Dyella japonica UNC79MFTsu3.2 0.54 ABZR86_RS06700 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.56 ABZR86_RS15965 branched-chain amino acid transaminase 0.97 2
Mucilaginibacter yixingensis YX-36 DSM 26809 0.54 ABZR88_RS06845 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.16 ABZR88_RS22095 branched-chain amino acid aminotransferase — —
Xanthomonas campestris pv. campestris strain 8004 0.54 Xcc-8004.2942.1 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.19 Xcc-8004.4199.1 Branched-chain amino acid aminotransferase (EC 2.6.1.42) 0.60 48
Pedobacter sp. GW460-11-11-14-LB5 0.52 CA265_RS03605 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.29 CA265_RS15785 branched-chain-amino-acid transaminase low > 88
Echinicola vietnamensis KMM 6221, DSM 17526 0.52 Echvi_2517 phosphoribosyl-ATP pyrophosphohydrolase 0.18 Echvi_2202 branched-chain amino acid aminotransferase, group II low > 79
Bacteroides thetaiotaomicron VPI-5482 0.51 BT1377 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (NCBI ptt file) 0.19 BT3892 branched-chain amino acid aminotransferase (NCBI ptt file) — —
Bacteroides ovatus ATCC 8483 0.51 BACOVA_00218 phosphoribosyl-ATP diphosphatase 0.30 BACOVA_03679 branched-chain-amino-acid transaminase low > 94
Bacteroides stercoris CC31F 0.50 HMPREF1181_RS11065 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.19 HMPREF1181_RS06865 branched-chain amino acid aminotransferase low > 56
Parabacteroides merdae CL09T00C40 0.50 HMPREF1078_RS13560 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.19 HMPREF1078_RS07855 branched-chain amino acid aminotransferase low > 61
Phocaeicola vulgatus CL09T03C04 0.49 HMPREF1058_RS06180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.18 HMPREF1058_RS02220 branched-chain amino acid aminotransferase 0.73 49
Phocaeicola dorei CL03T12C01 0.49 ABI39_RS19935 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.18 ABI39_RS01415 branched-chain amino acid aminotransferase 0.60 64
Pontibacter actiniarum KMM 6156, DSM 19842 0.48 CA264_05115 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.32 CA264_06940 branched-chain amino acid aminotransferase low > 74
Lysobacter sp. OAE881 0.47 ABIE51_RS13295 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.55 ABIE51_RS16505 branched-chain amino acid transaminase low > 62
Brevundimonas sp. GW460-12-10-14-LB2 0.46 A4249_RS10720 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.27 A4249_RS09820 branched-chain amino acid aminotransferase — —
Synechococcus elongatus PCC 7942 0.35 Synpcc7942_1995 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein 0.29 Synpcc7942_1029 ilvE branched-chain amino acid aminotransferase — —
Acinetobacter radioresistens SK82 0.31 MPMX26_00264 Histidine biosynthesis bifunctional protein HisIE 0.40 MPMX26_00445 Branched-chain-amino-acid aminotransferase 0.91 18

Not shown: 0 genomes with orthologs for b2026 only; 53 genomes with orthologs for b3770 only