Conservation of cofitness between b3958 and b3368 in Escherichia coli BW25113

51 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b3958 argC N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) 1.0 b3368 cysG fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) 0.91 10
Escherichia coli ECOR27 1.00 NOLOHH_05730 argC N-acetyl-gamma-glutamyl-phosphate reductase 1.00 NOLOHH_08980 cysG siroheme synthase CysG low > 57
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_04092 N-acetyl-gamma-glutamyl-phosphate reductase 1.00 OHPLBJKB_00334 Siroheme synthase low > 73
Escherichia coli ECRC62 1.00 BNILDI_05795 argC N-acetyl-gamma-glutamyl-phosphate reductase 1.00 BNILDI_02540 cysG siroheme synthase CysG — —
Escherichia coli BL21 1.00 ECD_03843 N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding 1.00 ECD_03219 fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase low > 60
Escherichia coli ECOR38 0.99 HEPCGN_12230 argC N-acetyl-gamma-glutamyl-phosphate reductase 1.00 HEPCGN_16010 cysG siroheme synthase CysG low > 85
Escherichia coli ECRC101 0.99 MCAODC_04085 argC N-acetyl-gamma-glutamyl-phosphate reductase 1.00 MCAODC_07710 cysG siroheme synthase CysG — —
Escherichia coli ECRC99 0.99 KEDOAH_14575 argC N-acetyl-gamma-glutamyl-phosphate reductase 1.00 KEDOAH_10960 cysG siroheme synthase CysG — —
Escherichia coli ECRC102 0.99 NIAGMN_11335 argC N-acetyl-gamma-glutamyl-phosphate reductase 1.00 NIAGMN_14950 cysG siroheme synthase CysG — —
Escherichia coli ECRC98 0.99 JDDGAC_17210 argC N-acetyl-gamma-glutamyl-phosphate reductase 1.00 JDDGAC_20810 cysG siroheme synthase CysG — —
Escherichia coli Nissle 1917 0.99 ECOLIN_RS22845 N-acetyl-gamma-glutamyl-phosphate reductase 1.00 ECOLIN_RS19285 siroheme synthase CysG low > 52
Escherichia fergusonii Becca 0.99 EFB2_04656 N-acetyl-gamma-glutamyl-phosphate reductase 1.00 EFB2_00454 Siroheme synthase low > 86
Escherichia coli ECRC101 0.99 OKFHMN_13585 argC N-acetyl-gamma-glutamyl-phosphate reductase 1.00 OKFHMN_17180 cysG siroheme synthase CysG — —
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.92 GFF2344 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) 0.92 GFF3700 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) low > 78
Klebsiella michiganensis M5al 0.91 BWI76_RS00845 N-acetyl-gamma-glutamyl-phosphate reductase 0.88 BWI76_RS26055 siroheme synthase 0.79 58
Enterobacter asburiae PDN3 0.90 EX28DRAFT_4420 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) 0.89 EX28DRAFT_4160 uroporphyrin-III C-methyltransferase 0.53 68
Enterobacter sp. TBS_079 0.89 MPMX20_04522 N-acetyl-gamma-glutamyl-phosphate reductase 0.89 MPMX20_04271 Siroheme synthase low > 85
Serratia liquefaciens MT49 0.82 IAI46_24515 N-acetyl-gamma-glutamyl-phosphate reductase 0.71 IAI46_23670 uroporphyrinogen-III C-methyltransferase low > 86
Rahnella sp. WP5 0.79 EX31_RS14190 N-acetyl-gamma-glutamyl-phosphate reductase 0.71 EX31_RS04680 uroporphyrinogen-III C-methyltransferase low > 89
Dickeya dianthicola 67-19 0.79 HGI48_RS00875 N-acetyl-gamma-glutamyl-phosphate reductase 0.51 HGI48_RS17000 uroporphyrinogen-III C-methyltransferase 0.75 38
Pectobacterium carotovorum WPP14 0.79 HER17_RS20630 N-acetyl-gamma-glutamyl-phosphate reductase 0.72 HER17_RS01835 siroheme synthase CysG low > 75
Dickeya dadantii 3937 0.78 DDA3937_RS20350 N-acetyl-gamma-glutamyl-phosphate reductase 0.51 DDA3937_RS16930 uroporphyrinogen-III C-methyltransferase 0.71 44
Pantoea sp. MT58 0.78 IAI47_00905 N-acetyl-gamma-glutamyl-phosphate reductase 0.50 IAI47_04175 uroporphyrinogen-III C-methyltransferase 0.66 70
Erwinia tracheiphila SCR3 0.78 LU632_RS19615 argC N-acetyl-gamma-glutamyl-phosphate reductase 0.53 LU632_RS06420 cysG siroheme synthase CysG low > 74
Dickeya dianthicola ME23 0.78 DZA65_RS00935 N-acetyl-gamma-glutamyl-phosphate reductase 0.50 DZA65_RS18075 uroporphyrinogen-III C-methyltransferase 0.71 47
Alteromonas macleodii MIT1002 0.47 MIT1002_00471 N-acetyl-gamma-glutamyl-phosphate reductase 0.45 MIT1002_00665 Siroheme synthase — —
Pseudomonas putida KT2440 0.32 PP_0432 N-acetyl-gamma-glutamyl-phosphate reductase 1 0.47 PP_3999 Uroporphyrinogen-III C-methyltransferase/Precorrin-2 dehydrogenase/Sirohydrochlorin ferrochelatase low > 96
Pseudomonas fluorescens SBW25-INTG 0.32 PFLU_RS27315 N-acetyl-gamma-glutamyl-phosphate reductase 0.48 PFLU_RS18505 uroporphyrinogen-III C-methyltransferase — —
Pseudomonas fluorescens SBW25 0.32 PFLU_RS27315 N-acetyl-gamma-glutamyl-phosphate reductase 0.48 PFLU_RS18505 uroporphyrinogen-III C-methyltransferase — —
Pseudomonas fluorescens FW300-N2C3 0.31 AO356_14490 N-acetyl-gamma-glutamyl-phosphate reductase 0.49 AO356_22200 sirohydrochlorin ferrochelatase low > 104
Pseudomonas simiae WCS417 0.31 PS417_25660 N-acetyl-gamma-glutamyl-phosphate reductase 0.48 PS417_16465 sirohydrochlorin ferrochelatase — —
Pseudomonas sp. S08-1 0.31 OH686_15195 N-acetyl-gamma-glutamyl-phosphate reductase 0.45 OH686_00285 Precorrin-2 oxidase or Sirohydrochlorin ferrochelatase activity of CysG / Uroporphyrinogen-III methyltransferase low > 80
Pseudomonas fluorescens FW300-N2E3 0.31 AO353_07155 N-acetyl-gamma-glutamyl-phosphate reductase 0.49 AO353_27625 sirohydrochlorin ferrochelatase — —
Pseudomonas fluorescens FW300-N1B4 0.31 Pf1N1B4_2559 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) 0.49 Pf1N1B4_4065 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) — —
Rhodospirillum rubrum S1H 0.31 Rru_A2421 N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) 0.27 Rru_A1933 Uroporphyrin-III C-methyltransferase (NCBI) low > 58
Pseudomonas fluorescens GW456-L13 0.31 PfGW456L13_1233 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) 0.49 PfGW456L13_2656 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.81 21
Pseudomonas fluorescens FW300-N2E2 0.31 Pf6N2E2_4836 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) 0.49 Pf6N2E2_302 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) low > 103
Pseudomonas sp. RS175 0.30 PFR28_04033 N-acetyl-gamma-glutamyl-phosphate reductase 0.49 PFR28_02603 Siroheme synthase low > 88
Pseudomonas syringae pv. syringae B728a 0.30 Psyr_4569 N-acetyl-gamma-glutamyl-phosphate reductase 0.49 Psyr_3174 uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase — —
Pseudomonas syringae pv. syringae B728a ΔmexB 0.30 Psyr_4569 N-acetyl-gamma-glutamyl-phosphate reductase 0.49 Psyr_3174 uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase — —
Castellaniella sp019104865 MT123 0.30 ABCV34_RS10590 N-acetyl-gamma-glutamyl-phosphate reductase 0.40 ABCV34_RS00210 siroheme synthase CysG — —
Pseudomonas stutzeri RCH2 0.29 Psest_3639 N-acetyl-gamma-glutamyl-phosphate reductase, common form 0.51 Psest_2037 uroporphyrin-III C-methyltransferase — —
Acinetobacter radioresistens SK82 0.29 MPMX26_01281 N-acetyl-gamma-glutamyl-phosphate reductase 0.45 MPMX26_00706 Siroheme synthase — —
Dinoroseobacter shibae DFL-12 0.24 Dshi_1759 N-acetyl-gamma-glutamyl-phosphate reductase (RefSeq) 0.27 Dshi_1155 uroporphyrin-III C-methyltransferase (RefSeq) — —
Mycobacterium tuberculosis H37Rv 0.21 Rv1652 Probable N-acetyl-gamma-glutamyl-phoshate reductase ArgC 0.20 Rv2847c Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase — —
Lysobacter sp. OAE881 0.20 ABIE51_RS13385 N-acetyl-gamma-glutamyl-phosphate reductase 0.43 ABIE51_RS15855 siroheme synthase CysG 0.98 16
Dyella japonica UNC79MFTsu3.2 0.18 ABZR86_RS08700 N-acetylglutamylphosphate reductase (EC 1.2.1.38) (from data) 0.44 ABZR86_RS05880 siroheme synthase CysG low > 74
Bosea sp. OAE506 0.18 ABIE41_RS15755 N-acetyl-gamma-glutamyl-phosphate reductase 0.26 ABIE41_RS15910 siroheme synthase CysG — —
Kangiella aquimarina DSM 16071 0.18 B158DRAFT_1979 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) 0.49 B158DRAFT_2163 uroporphyrin-III C-methyltransferase low > 40
Rhodanobacter sp. FW510-T8 0.17 OKGIIK_09435 argC N-acetyl-gamma-glutamyl-phosphate reductase 0.40 OKGIIK_05980 cysG siroheme synthase CysG low > 52
Rhodanobacter denitrificans MT42 0.17 LRK55_RS02140 N-acetyl-gamma-glutamyl-phosphate reductase 0.37 LRK55_RS00685 siroheme synthase CysG low > 63
Rhodanobacter denitrificans FW104-10B01 0.17 LRK54_RS02385 N-acetyl-gamma-glutamyl-phosphate reductase 0.38 LRK54_RS00910 siroheme synthase CysG 0.68 38

Not shown: 38 genomes with orthologs for b3958 only; 5 genomes with orthologs for b3368 only