Conservation of cofitness between b2020 and b2026 in Escherichia coli BW25113

49 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b2020 hisD histidinol dehydrogenase (NCBI) 1.0 b2026 hisI bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) 0.96 12
Escherichia coli ECOR27 0.99 NOLOHH_15830 hisD Histidinol dehydrogenase 0.92 NOLOHH_15800 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 57
Escherichia coli ECRC62 0.99 BNILDI_14740 hisD Histidinol dehydrogenase 0.98 BNILDI_14710 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli BL21 0.99 ECD_01922 bifunctional histidinal dehydrogenase/ histidinol dehydrogenase 1.00 ECD_01928 phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase low > 60
Escherichia coli Nissle 1917 0.99 ECOLIN_RS11945 histidinol dehydrogenase 0.99 ECOLIN_RS11975 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECOR38 0.99 HEPCGN_03220 hisD Histidinol dehydrogenase 0.99 HEPCGN_03190 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 85
Escherichia coli HS(pFamp)R (ATCC 700891) 0.98 OHPLBJKB_01680 Histidinol dehydrogenase 0.96 OHPLBJKB_01674 Histidine biosynthesis bifunctional protein HisIE low > 73
Escherichia fergusonii Becca 0.98 EFB2_01836 Histidinol dehydrogenase 0.98 EFB2_01830 Histidine biosynthesis bifunctional protein HisIE low > 86
Escherichia coli ECRC101 0.98 OKFHMN_24515 hisD Histidinol dehydrogenase 0.99 OKFHMN_24485 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC98 0.98 JDDGAC_28625 hisD Histidinol dehydrogenase 0.99 JDDGAC_28595 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC102 0.98 NIAGMN_22460 hisD Histidinol dehydrogenase 0.99 NIAGMN_22430 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC99 0.98 KEDOAH_03635 hisD Histidinol dehydrogenase 0.99 KEDOAH_03665 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC101 0.98 MCAODC_20425 hisD Histidinol dehydrogenase 0.99 MCAODC_20455 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.93 GFF3912 Histidinol dehydrogenase (EC 1.1.1.23) 0.89 GFF3906 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) low > 78
Enterobacter asburiae PDN3 0.89 EX28DRAFT_0539 histidinol dehydrogenase 0.91 EX28DRAFT_0533 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19)/phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.94 7
Enterobacter sp. TBS_079 0.89 MPMX20_03002 Histidinol dehydrogenase 0.91 MPMX20_03008 Histidine biosynthesis bifunctional protein HisIE 0.95 8
Klebsiella michiganensis M5al 0.88 BWI76_RS18925 histidinol dehydrogenase 0.87 BWI76_RS18955 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.87 25
Serratia liquefaciens MT49 0.85 IAI46_08210 histidinol dehydrogenase 0.76 IAI46_08180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.91 3
Pantoea sp. MT58 0.82 IAI47_07090 histidinol dehydrogenase 0.81 IAI47_07060 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.98 6
Erwinia tracheiphila SCR3 0.81 LU632_RS08945 hisD histidinol dehydrogenase 0.76 LU632_RS08915 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.92 5
Dickeya dadantii 3937 0.80 DDA3937_RS09735 histidinol dehydrogenase 0.81 DDA3937_RS09705 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.97 4
Pectobacterium carotovorum WPP14 0.80 HER17_RS12230 histidinol dehydrogenase 0.70 HER17_RS12260 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.95 33
Dickeya dianthicola 67-19 0.79 HGI48_RS09745 histidinol dehydrogenase 0.80 HGI48_RS09715 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 71
Dickeya dianthicola ME23 0.79 DZA65_RS10055 histidinol dehydrogenase 0.80 DZA65_RS10025 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.86 10
Rahnella sp. WP5 0.79 EX31_RS11440 histidinol dehydrogenase 0.76 EX31_RS11470 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.95 38
Vibrio cholerae E7946 ATCC 55056 0.63 CSW01_05750 histidinol dehydrogenase 0.64 CSW01_05780 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase low > 62
Shewanella amazonensis SB2B 0.59 Sama_1942 hisD histidinol dehydrogenase (RefSeq) 0.61 Sama_1948 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.98 5
Shewanella loihica PV-4 0.57 Shew_2198 histidinol dehydrogenase (RefSeq) 0.57 Shew_2204 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.93 14
Shewanella oneidensis MR-1 0.57 SO2073 hisD histidinol dehydrogenase (NCBI ptt file) 0.62 SO2067 hisI phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase (NCBI ptt file) 0.95 32
Shewanella sp. ANA-3 0.56 Shewana3_1853 hisD histidinol dehydrogenase (RefSeq) 0.60 Shewana3_1847 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.94 16
Alteromonas macleodii MIT1002 0.54 MIT1002_02633 Histidinol dehydrogenase 0.63 MIT1002_02639 Phosphoribosyl-ATP pyrophosphatase 0.95 43
Rhodanobacter denitrificans FW104-10B01 0.53 LRK54_RS01605 histidinol dehydrogenase 0.55 LRK54_RS01575 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.90 1
Rhodanobacter denitrificans MT42 0.53 LRK55_RS01385 histidinol dehydrogenase 0.56 LRK55_RS01355 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.76 7
Dyella japonica UNC79MFTsu3.2 0.53 ABZR86_RS06730 histidinol dehydrogenase 0.54 ABZR86_RS06700 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.96 15
Bacteroides ovatus ATCC 8483 0.53 BACOVA_01234 histidinol dehydrogenase 0.51 BACOVA_00218 phosphoribosyl-ATP diphosphatase 0.98 4
Rhodanobacter sp. FW510-T8 0.53 OKGIIK_04950 hisD histidinol dehydrogenase 0.55 OKGIIK_04980 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 52
Bacteroides thetaiotaomicron VPI-5482 0.52 BT0201 histidinol dehydrogenase (NCBI ptt file) 0.51 BT1377 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (NCBI ptt file) 0.92 11
Phocaeicola vulgatus CL09T03C04 0.51 HMPREF1058_RS15875 histidinol dehydrogenase 0.49 HMPREF1058_RS06180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.96 9
Bacteroides stercoris CC31F 0.50 HMPREF1181_RS04860 histidinol dehydrogenase 0.50 HMPREF1181_RS11065 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.96 10
Phocaeicola dorei CL03T12C01 0.50 ABI39_RS11835 histidinol dehydrogenase 0.49 ABI39_RS19935 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.72 44
Lysobacter sp. OAE881 0.49 ABIE51_RS13325 histidinol dehydrogenase 0.47 ABIE51_RS13295 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.98 14
Parabacteroides merdae CL09T00C40 0.48 HMPREF1078_RS02450 histidinol dehydrogenase 0.50 HMPREF1078_RS13560 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.95 40
Xanthomonas campestris pv. campestris strain 8004 0.48 Xcc-8004.2948.1 Histidinol dehydrogenase (EC 1.1.1.23) 0.54 Xcc-8004.2942.1 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.91 7
Echinicola vietnamensis KMM 6221, DSM 17526 0.47 Echvi_2459 histidinol dehydrogenase 0.52 Echvi_2517 phosphoribosyl-ATP pyrophosphohydrolase 0.95 6
Pontibacter actiniarum KMM 6156, DSM 19842 0.45 CA264_05030 histidinol dehydrogenase 0.48 CA264_05115 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase low > 74
Pedobacter sp. GW460-11-11-14-LB5 0.44 CA265_RS03635 histidinol dehydrogenase 0.52 CA265_RS03605 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.96 3
Mucilaginibacter yixingensis YX-36 DSM 26809 0.44 ABZR88_RS06880 histidinol dehydrogenase 0.54 ABZR88_RS06845 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Brevundimonas sp. GW460-12-10-14-LB2 0.38 A4249_RS10695 histidinol dehydrogenase 0.46 A4249_RS10720 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.99 18
Synechococcus elongatus PCC 7942 0.33 Synpcc7942_1519 hisD histidinol dehydrogenase 0.35 Synpcc7942_1995 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein — —
Acinetobacter radioresistens SK82 0.32 MPMX26_02587 Histidinol dehydrogenase 0.31 MPMX26_00264 Histidine biosynthesis bifunctional protein HisIE 0.99 1

Not shown: 52 genomes with orthologs for b2020 only; 0 genomes with orthologs for b2026 only