Conservation of cofitness between b0243 and b2026 in Escherichia coli BW25113

49 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b0243 proA gamma-glutamyl phosphate reductase (NCBI) 1.0 b2026 hisI bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) 0.94 11
Escherichia coli ECOR27 0.99 NOLOHH_02045 proA glutamate-5-semialdehyde dehydrogenase 0.92 NOLOHH_15800 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 57
Escherichia coli ECOR38 0.99 HEPCGN_07775 proA glutamate-5-semialdehyde dehydrogenase 0.99 HEPCGN_03190 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 85
Escherichia coli BL21 0.99 ECD_00240 gamma-glutamylphosphate reductase 1.00 ECD_01928 phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase low > 60
Escherichia coli HS(pFamp)R (ATCC 700891) 0.99 OHPLBJKB_03397 Gamma-glutamyl phosphate reductase 0.96 OHPLBJKB_01674 Histidine biosynthesis bifunctional protein HisIE low > 73
Escherichia coli ECRC62 0.99 BNILDI_00240 proA glutamate-5-semialdehyde dehydrogenase 0.98 BNILDI_14710 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli Nissle 1917 0.99 ECOLIN_RS01830 glutamate-5-semialdehyde dehydrogenase 0.99 ECOLIN_RS11975 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC101 0.99 MCAODC_00190 proA glutamate-5-semialdehyde dehydrogenase 0.99 MCAODC_20455 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC98 0.99 JDDGAC_13295 proA glutamate-5-semialdehyde dehydrogenase 0.99 JDDGAC_28595 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC102 0.99 NIAGMN_07530 proA glutamate-5-semialdehyde dehydrogenase 0.99 NIAGMN_22430 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC99 0.99 KEDOAH_18485 proA glutamate-5-semialdehyde dehydrogenase 0.99 KEDOAH_03665 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC101 0.99 OKFHMN_09670 proA glutamate-5-semialdehyde dehydrogenase 0.99 OKFHMN_24485 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia fergusonii Becca 0.99 EFB2_03777 Gamma-glutamyl phosphate reductase 0.98 EFB2_01830 Histidine biosynthesis bifunctional protein HisIE low > 86
Enterobacter asburiae PDN3 0.88 EX28DRAFT_2650 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) 0.91 EX28DRAFT_0533 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19)/phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.93 4
Enterobacter sp. TBS_079 0.88 MPMX20_00928 Gamma-glutamyl phosphate reductase 0.91 MPMX20_03008 Histidine biosynthesis bifunctional protein HisIE 0.90 28
Klebsiella michiganensis M5al 0.86 BWI76_RS05835 gamma-glutamyl-phosphate reductase 0.87 BWI76_RS18955 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.76 44
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.86 GFF4115 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) 0.89 GFF3906 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) low > 78
Dickeya dadantii 3937 0.79 DDA3937_RS16530 glutamate-5-semialdehyde dehydrogenase 0.81 DDA3937_RS09705 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.77 18
Dickeya dianthicola ME23 0.78 DZA65_RS17690 glutamate-5-semialdehyde dehydrogenase 0.80 DZA65_RS10025 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 75
Serratia liquefaciens MT49 0.77 IAI46_04435 glutamate-5-semialdehyde dehydrogenase 0.76 IAI46_08180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 86
Pantoea sp. MT58 0.75 IAI47_15115 glutamate-5-semialdehyde dehydrogenase 0.81 IAI47_07060 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.92 25
Erwinia tracheiphila SCR3 0.74 LU632_RS01190 proA glutamate-5-semialdehyde dehydrogenase 0.76 LU632_RS08915 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 74
Dickeya dianthicola 67-19 0.74 HGI48_RS16600 glutamate-5-semialdehyde dehydrogenase 0.80 HGI48_RS09715 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 71
Pectobacterium carotovorum WPP14 0.74 HER17_RS04705 glutamate-5-semialdehyde dehydrogenase 0.70 HER17_RS12260 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.95 17
Rahnella sp. WP5 0.73 EX31_RS20975 glutamate-5-semialdehyde dehydrogenase 0.76 EX31_RS11470 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.95 35
Vibrio cholerae E7946 ATCC 55056 0.58 CSW01_11570 glutamate-5-semialdehyde dehydrogenase 0.64 CSW01_05780 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase low > 62
Shewanella loihica PV-4 0.57 Shew_2847 proA gamma-glutamyl phosphate reductase (RefSeq) 0.57 Shew_2204 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.96 26
Shewanella sp. ANA-3 0.56 Shewana3_0955 proA gamma-glutamyl phosphate reductase (RefSeq) 0.60 Shewana3_1847 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.93 36
Shewanella oneidensis MR-1 0.56 SO1122 proA gamma-glutamyl phosphate reductase (NCBI ptt file) 0.62 SO2067 hisI phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase (NCBI ptt file) 0.94 40
Shewanella amazonensis SB2B 0.55 Sama_2515 proA gamma-glutamyl phosphate reductase (RefSeq) 0.61 Sama_1948 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.94 27
Acinetobacter radioresistens SK82 0.44 MPMX26_00417 Gamma-glutamyl phosphate reductase 0.31 MPMX26_00264 Histidine biosynthesis bifunctional protein HisIE low > 36
Bacteroides stercoris CC31F 0.42 HMPREF1181_RS03320 glutamate-5-semialdehyde dehydrogenase 0.50 HMPREF1181_RS11065 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.94 21
Pontibacter actiniarum KMM 6156, DSM 19842 0.42 CA264_07720 gamma-glutamyl-phosphate reductase 0.48 CA264_05115 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase low > 74
Rhodanobacter denitrificans FW104-10B01 0.41 LRK54_RS02370 glutamate-5-semialdehyde dehydrogenase 0.55 LRK54_RS01575 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.82 20
Rhodanobacter denitrificans MT42 0.41 LRK55_RS02125 glutamate-5-semialdehyde dehydrogenase 0.56 LRK55_RS01355 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 63
Xanthomonas campestris pv. campestris strain 8004 0.41 Xcc-8004.2327.1 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) 0.54 Xcc-8004.2942.1 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) low > 74
Alteromonas macleodii MIT1002 0.40 MIT1002_01885 Gamma-glutamyl phosphate reductase 0.63 MIT1002_02639 Phosphoribosyl-ATP pyrophosphatase 0.97 25
Lysobacter sp. OAE881 0.40 ABIE51_RS13365 glutamate-5-semialdehyde dehydrogenase 0.47 ABIE51_RS13295 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.90 34
Mucilaginibacter yixingensis YX-36 DSM 26809 0.39 ABZR88_RS22165 glutamate-5-semialdehyde dehydrogenase 0.54 ABZR88_RS06845 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Pedobacter sp. GW460-11-11-14-LB5 0.39 CA265_RS20850 glutamate-5-semialdehyde dehydrogenase 0.52 CA265_RS03605 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.92 24
Dyella japonica UNC79MFTsu3.2 0.39 ABZR86_RS08680 glutamate-5-semialdehyde dehydrogenase 0.54 ABZR86_RS06700 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.85 46
Bacteroides thetaiotaomicron VPI-5482 0.39 BT3718 gamma-glutamyl phosphate reductase (NCBI ptt file) 0.51 BT1377 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (NCBI ptt file) 0.95 6
Bacteroides ovatus ATCC 8483 0.38 BACOVA_03534 glutamate-5-semialdehyde dehydrogenase 0.51 BACOVA_00218 phosphoribosyl-ATP diphosphatase 0.94 27
Rhodanobacter sp. FW510-T8 0.37 OKGIIK_09415 proA glutamate-5-semialdehyde dehydrogenase 0.55 OKGIIK_04980 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 52
Phocaeicola dorei CL03T12C01 0.35 ABI39_RS02875 glutamate-5-semialdehyde dehydrogenase 0.49 ABI39_RS19935 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.72 48
Phocaeicola vulgatus CL09T03C04 0.35 HMPREF1058_RS08645 glutamate-5-semialdehyde dehydrogenase 0.49 HMPREF1058_RS06180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.95 12
Parabacteroides merdae CL09T00C40 0.35 HMPREF1078_RS10655 glutamate-5-semialdehyde dehydrogenase 0.50 HMPREF1078_RS13560 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.93 43
Synechococcus elongatus PCC 7942 0.35 Synpcc7942_2265 proA glutamate-5-semialdehyde dehydrogenase 0.35 Synpcc7942_1995 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein — —
Brevundimonas sp. GW460-12-10-14-LB2 0.34 A4249_RS16120 glutamate-5-semialdehyde dehydrogenase 0.46 A4249_RS10720 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.99 33
Echinicola vietnamensis KMM 6221, DSM 17526 0.29 Echvi_2633 gamma-glutamylphosphate reductase (EC 1.2.1.41) (from data) 0.52 Echvi_2517 phosphoribosyl-ATP pyrophosphohydrolase 0.83 33

Not shown: 51 genomes with orthologs for b0243 only; 0 genomes with orthologs for b2026 only