Conservation of cofitness between b2026 and b2021 in Escherichia coli BW25113

49 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b2026 hisI bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) 1.0 b2021 hisC histidinol-phosphate aminotransferase (NCBI) 0.94 14
Escherichia coli BL21 1.00 ECD_01928 phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase 0.99 ECD_01923 histidinol-phosphate aminotransferase low > 60
Escherichia coli Nissle 1917 0.99 ECOLIN_RS11975 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.99 ECOLIN_RS11950 histidinol-phosphate transaminase — —
Escherichia coli ECRC99 0.99 KEDOAH_03665 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 KEDOAH_03640 hisC histidinol-phosphate transaminase — —
Escherichia coli ECOR38 0.99 HEPCGN_03190 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.99 HEPCGN_03215 hisC histidinol-phosphate transaminase low > 85
Escherichia coli ECRC101 0.99 MCAODC_20455 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 MCAODC_20430 hisC histidinol-phosphate transaminase — —
Escherichia coli ECRC102 0.99 NIAGMN_22430 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 NIAGMN_22455 hisC histidinol-phosphate transaminase — —
Escherichia coli ECRC98 0.99 JDDGAC_28595 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 JDDGAC_28620 hisC histidinol-phosphate transaminase — —
Escherichia coli ECRC101 0.99 OKFHMN_24485 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 OKFHMN_24510 hisC histidinol-phosphate transaminase — —
Escherichia coli ECRC62 0.98 BNILDI_14710 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.99 BNILDI_14735 hisC histidinol-phosphate transaminase — —
Escherichia fergusonii Becca 0.98 EFB2_01830 Histidine biosynthesis bifunctional protein HisIE 1.00 EFB2_01835 Histidinol-phosphate aminotransferase low > 86
Escherichia coli HS(pFamp)R (ATCC 700891) 0.96 OHPLBJKB_01674 Histidine biosynthesis bifunctional protein HisIE 0.99 OHPLBJKB_01679 Histidinol-phosphate aminotransferase low > 73
Escherichia coli ECOR27 0.92 NOLOHH_15800 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 NOLOHH_15825 hisC histidinol-phosphate transaminase low > 57
Enterobacter asburiae PDN3 0.91 EX28DRAFT_0533 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19)/phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.89 EX28DRAFT_0538 histidinol-phosphate aminotransferase 0.92 8
Enterobacter sp. TBS_079 0.91 MPMX20_03008 Histidine biosynthesis bifunctional protein HisIE 0.89 MPMX20_03003 Histidinol-phosphate aminotransferase 0.93 10
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.89 GFF3906 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.91 GFF3911 Histidinol-phosphate aminotransferase (EC 2.6.1.9) low > 78
Klebsiella michiganensis M5al 0.87 BWI76_RS18955 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.87 BWI76_RS18930 histidinol-phosphate transaminase 0.87 23
Dickeya dadantii 3937 0.81 DDA3937_RS09705 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.73 DDA3937_RS09730 histidinol-phosphate transaminase 0.97 3
Pantoea sp. MT58 0.81 IAI47_07060 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.76 IAI47_07085 histidinol-phosphate transaminase 0.98 1
Dickeya dianthicola 67-19 0.80 HGI48_RS09715 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.73 HGI48_RS09740 histidinol-phosphate transaminase 0.52 38
Dickeya dianthicola ME23 0.80 DZA65_RS10025 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.73 DZA65_RS10050 histidinol-phosphate transaminase 0.79 33
Erwinia tracheiphila SCR3 0.76 LU632_RS08915 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.76 LU632_RS08940 hisC histidinol-phosphate transaminase 0.94 3
Rahnella sp. WP5 0.76 EX31_RS11470 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.76 EX31_RS11445 histidinol-phosphate transaminase 0.95 10
Serratia liquefaciens MT49 0.76 IAI46_08180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.78 IAI46_08205 histidinol-phosphate transaminase 0.95 2
Pectobacterium carotovorum WPP14 0.70 HER17_RS12260 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.74 HER17_RS12235 histidinol-phosphate transaminase 0.94 32
Vibrio cholerae E7946 ATCC 55056 0.64 CSW01_05780 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.58 CSW01_05755 histidinol-phosphate transaminase low > 62
Alteromonas macleodii MIT1002 0.63 MIT1002_02639 Phosphoribosyl-ATP pyrophosphatase 0.49 MIT1002_02634 Histidinol-phosphate aminotransferase 0.92 42
Shewanella oneidensis MR-1 0.62 SO2067 hisI phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase (NCBI ptt file) 0.42 SO2072 hisC histidinol-phosphate aminotransferase (NCBI ptt file) 0.96 1
Shewanella amazonensis SB2B 0.61 Sama_1948 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.33 Sama_1943 histidinol-phosphate aminotransferase (RefSeq) 0.98 1
Shewanella sp. ANA-3 0.60 Shewana3_1847 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.42 Shewana3_1852 histidinol phosphate aminotransferase (RefSeq) 0.95 1
Shewanella loihica PV-4 0.57 Shew_2204 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.40 Shew_2199 histidinol-phosphate aminotransferase (RefSeq) 0.95 24
Rhodanobacter denitrificans MT42 0.56 LRK55_RS01355 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.37 LRK55_RS01380 histidinol-phosphate transaminase 0.77 6
Rhodanobacter denitrificans FW104-10B01 0.55 LRK54_RS01575 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.38 LRK54_RS01600 histidinol-phosphate transaminase 0.83 4
Rhodanobacter sp. FW510-T8 0.55 OKGIIK_04980 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.38 OKGIIK_04955 hisC histidinol-phosphate transaminase low > 52
Dyella japonica UNC79MFTsu3.2 0.54 ABZR86_RS06700 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.35 ABZR86_RS06725 histidinol-phosphate transaminase 0.97 1
Mucilaginibacter yixingensis YX-36 DSM 26809 0.54 ABZR88_RS06845 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.34 ABZR88_RS06875 histidinol-phosphate transaminase — —
Xanthomonas campestris pv. campestris strain 8004 0.54 Xcc-8004.2942.1 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.38 Xcc-8004.2947.1 Histidinol-phosphate aminotransferase (EC 2.6.1.9) 0.91 2
Pedobacter sp. GW460-11-11-14-LB5 0.52 CA265_RS03605 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.36 CA265_RS03630 histidinol-phosphate transaminase 0.96 4
Echinicola vietnamensis KMM 6221, DSM 17526 0.52 Echvi_2517 phosphoribosyl-ATP pyrophosphohydrolase 0.32 Echvi_2458 histidinol-phosphate aminotransferase 0.96 1
Bacteroides ovatus ATCC 8483 0.51 BACOVA_00218 phosphoribosyl-ATP diphosphatase 0.29 BACOVA_01233 histidinol-phosphate transaminase 0.98 3
Bacteroides thetaiotaomicron VPI-5482 0.51 BT1377 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (NCBI ptt file) 0.27 BT0202 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) 0.94 2
Bacteroides stercoris CC31F 0.50 HMPREF1181_RS11065 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.29 HMPREF1181_RS04855 histidinol-phosphate transaminase 0.97 1
Parabacteroides merdae CL09T00C40 0.50 HMPREF1078_RS13560 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.32 HMPREF1078_RS02445 histidinol-phosphate transaminase 0.95 14
Phocaeicola dorei CL03T12C01 0.49 ABI39_RS19935 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.28 ABI39_RS11840 histidinol-phosphate transaminase 0.68 38
Phocaeicola vulgatus CL09T03C04 0.49 HMPREF1058_RS06180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.28 HMPREF1058_RS15880 histidinol-phosphate transaminase 0.95 4
Pontibacter actiniarum KMM 6156, DSM 19842 0.48 CA264_05115 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.35 CA264_05035 histidinol-phosphate transaminase low > 74
Lysobacter sp. OAE881 0.47 ABIE51_RS13295 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.34 ABIE51_RS13320 histidinol-phosphate transaminase 0.95 30
Brevundimonas sp. GW460-12-10-14-LB2 0.46 A4249_RS10720 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.15 A4249_RS11450 histidinol-phosphate transaminase 0.98 43
Synechococcus elongatus PCC 7942 0.35 Synpcc7942_1995 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein 0.16 Synpcc7942_1030 hisC histidinol-phosphate aminotransferase — —
Acinetobacter radioresistens SK82 0.31 MPMX26_00264 Histidine biosynthesis bifunctional protein HisIE 0.17 MPMX26_02586 Histidinol-phosphate aminotransferase 0.98 6

Not shown: 0 genomes with orthologs for b2026 only; 52 genomes with orthologs for b2021 only