Conservation of cofitness between BWI76_RS23865 and BWI76_RS18410 in Klebsiella michiganensis M5al

40 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS23865 NAD(P)-dependent oxidoreductase 1.0 BWI76_RS18410 drug/metabolite exporter YedA 0.23 10
Enterobacter asburiae PDN3 0.87 EX28DRAFT_2954 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) 0.74 EX28DRAFT_0595 Predicted permease, DMT superfamily low > 76
Enterobacter sp. TBS_079 0.85 MPMX20_03761 putative oxidoreductase YgfF 0.77 MPMX20_02955 putative inner membrane transporter YedA low > 85
Escherichia coli BW25113 0.83 b2902 ygfF predicted NAD(P)-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain (NCBI) 0.73 b1959 yedA predicted inner membrane protein (NCBI) low > 76
Escherichia coli ECRC62 0.83 BNILDI_09985 ygfF SDR family oxidoreductase 0.77 BNILDI_15030 yedA drug/metabolite exporter YedA low > 75
Escherichia coli HS(pFamp)R (ATCC 700891) 0.82 OHPLBJKB_00813 putative oxidoreductase YgfF 0.73 OHPLBJKB_01769 putative inner membrane transporter YedA low > 73
Escherichia coli ECOR27 0.82 NOLOHH_11450 ygfF SDR family oxidoreductase 0.73 NOLOHH_16240 yedA drug/metabolite exporter YedA low > 75
Rahnella sp. WP5 0.80 EX31_RS21525 SDR family oxidoreductase 0.67 EX31_RS23955 drug/metabolite exporter YedA low > 89
Serratia liquefaciens MT49 0.74 IAI46_20810 SDR family oxidoreductase 0.62 IAI46_07395 drug/metabolite exporter YedA low > 86
Acidovorax sp. GW101-3H11 0.60 Ac3H11_2151 Short chain dehydrogenase 0.26 Ac3H11_4554 Permease of the drug/metabolite transporter (DMT) superfamily low > 79
Pseudomonas sp. S08-1 0.60 OH686_04500 Oxidoreductase, short-chain dehydrogenase/reductase family 0.19 OH686_04575 hypothetical protein low > 80
Dechlorosoma suillum PS 0.60 Dsui_3259 dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like protein 0.11 Dsui_0488 EamA-like transporter family low > 51
Lysobacter sp. OAE881 0.60 ABIE51_RS01825 SDR family oxidoreductase 0.32 ABIE51_RS03200 drug/metabolite exporter YedA low > 62
Variovorax sp. OAS795 0.58 ABID97_RS00750 SDR family oxidoreductase 0.26 ABID97_RS13970 drug/metabolite exporter YedA low > 91
Pseudomonas fluorescens SBW25-INTG 0.58 PFLU_RS13450 SDR family oxidoreductase 0.48 PFLU_RS26430 drug/metabolite exporter YedA low > 109
Pseudomonas fluorescens FW300-N2E2 0.58 Pf6N2E2_1794 FIG00553873: hypothetical protein 0.48 Pf6N2E2_5045 Permease of the drug/metabolite transporter (DMT) superfamily low > 103
Pseudomonas fluorescens FW300-N1B4 0.58 Pf1N1B4_4671 Short-chain dehydrogenase/reductase SDR 0.48 Pf1N1B4_2735 Permease of the drug/metabolite transporter (DMT) superfamily low > 87
Pseudomonas fluorescens SBW25 0.58 PFLU_RS13450 SDR family oxidoreductase 0.48 PFLU_RS26430 drug/metabolite exporter YedA low > 109
Pseudomonas fluorescens FW300-N2C3 0.58 AO356_29335 sugar dehydrogenase 0.48 AO356_15525 hypothetical protein low > 104
Pseudomonas simiae WCS417 0.57 PS417_12765 oxidoreductase 0.47 PS417_24505 membrane protein low > 88
Pseudomonas fluorescens FW300-N2E3 0.57 AO353_22915 oxidoreductase 0.48 AO353_06270 hypothetical protein low > 101
Pseudomonas sp. RS175 0.57 PFR28_01474 putative oxidoreductase YgfF 0.48 PFR28_03826 putative inner membrane transporter YedA low > 88
Hydrogenophaga sp. GW460-11-11-14-LB1 0.57 GFF1818 Short chain dehydrogenase 0.23 GFF134 Permease of the drug/metabolite transporter (DMT) superfamily low > 90
Azospirillum sp. SherDot2 0.56 MPMX19_06233 putative oxidoreductase YgfF 0.12 MPMX19_01772 putative inner membrane transporter YedA low > 112
Paraburkholderia bryophila 376MFSha3.1 0.56 H281DRAFT_01792 NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family 0.24 H281DRAFT_00402 Permease of the drug/metabolite transporter (DMT) superfamily low > 103
Variovorax sp. SCN45 0.56 GFF3615 Oxidoreductase, short-chain dehydrogenase/reductase family 0.24 GFF940 Permease of the drug/metabolite transporter (DMT) superfamily low > 127
Pseudomonas fluorescens GW456-L13 0.55 PfGW456L13_3262 Short-chain dehydrogenase/reductase SDR 0.48 PfGW456L13_1408 Permease of the drug/metabolite transporter (DMT) superfamily low > 87
Pseudomonas syringae pv. syringae B728a ΔmexB 0.53 Psyr_2487 Short-chain dehydrogenase/reductase SDR 0.45 Psyr_4298 Protein of unknown function DUF6 low > 86
Pseudomonas syringae pv. syringae B728a 0.53 Psyr_2487 Short-chain dehydrogenase/reductase SDR 0.45 Psyr_4298 Protein of unknown function DUF6 low > 86
Rhizobium sp. OAE497 0.52 ABIE40_RS17965 SDR family oxidoreductase 0.14 ABIE40_RS30600 EamA family transporter low > 107
Burkholderia phytofirmans PsJN 0.52 BPHYT_RS06495 glucose-1-dehydrogenase 0.24 BPHYT_RS13190 membrane protein low > 109
Paraburkholderia graminis OAS925 0.52 ABIE53_001564 NAD(P)-dependent dehydrogenase (short-subunit alcohol dehydrogenase family) 0.24 ABIE53_002851 drug/metabolite transporter (DMT)-like permease low > 113
Ralstonia solanacearum GMI1000 0.51 RS_RS12555 KR domain-containing protein 0.26 RS_RS21045 GntR family transcriptional regulator low > 80
Ralstonia solanacearum PSI07 0.51 RPSI07_RS12355 KR domain-containing protein 0.26 RPSI07_RS03405 GntR family transcriptional regulator low > 81
Ralstonia solanacearum UW163 0.50 UW163_RS08690 glucose-1-dehydrogenase 0.25 UW163_RS19390 GntR family transcriptional regulator — —
Paraburkholderia sabiae LMG 24235 0.50 QEN71_RS24295 SDR family oxidoreductase 0.25 QEN71_RS05485 EamA family transporter low > 153
Ralstonia solanacearum IBSBF1503 0.50 RALBFv3_RS04935 glucose-1-dehydrogenase 0.25 RALBFv3_RS19785 GntR family transcriptional regulator low > 76
Sinorhizobium meliloti 1021 0.49 SMc02486 oxidoreductase 0.13 SMc02511 hypothetical protein low > 103
Ralstonia sp. UNC404CL21Col 0.47 ABZR87_RS00555 SDR family oxidoreductase 0.27 ABZR87_RS20410 EamA family transporter low > 80
Bosea sp. OAE506 0.40 ABIE41_RS19215 SDR family oxidoreductase 0.13 ABIE41_RS06560 EamA family transporter low > 77
Agrobacterium fabrum C58 0.35 Atu4877 short-chain dehydrogenase 0.14 Atu2334 hypothetical protein low > 89

Not shown: 13 genomes with orthologs for BWI76_RS23865 only; 22 genomes with orthologs for BWI76_RS18410 only