Conservation of cofitness between Shewana3_1847 and Shewana3_3761 in Shewanella sp. ANA-3

43 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Shewanella sp. ANA-3 1.0 Shewana3_1847 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 1.0 Shewana3_3761 2-isopropylmalate synthase (RefSeq) 0.93 9
Shewanella oneidensis MR-1 0.86 SO2067 hisI phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase (NCBI ptt file) 0.98 SO4236 leuA 2-isopropylmalate synthase (NCBI ptt file) 0.94 9
Shewanella loihica PV-4 0.73 Shew_2204 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.86 Shew_3472 2-isopropylmalate synthase (RefSeq) 0.97 2
Shewanella amazonensis SB2B 0.66 Sama_1948 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.88 Sama_0335 2-isopropylmalate synthase (RefSeq) 0.91 41
Enterobacter sp. TBS_079 0.57 MPMX20_03008 Histidine biosynthesis bifunctional protein HisIE 0.66 MPMX20_00769 2-isopropylmalate synthase 0.93 13
Alteromonas macleodii MIT1002 0.56 MIT1002_02639 Phosphoribosyl-ATP pyrophosphatase 0.68 MIT1002_00949 2-isopropylmalate synthase 0.95 16
Pantoea sp. MT58 0.56 IAI47_07060 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.66 IAI47_16000 2-isopropylmalate synthase 0.97 13
Escherichia coli BL21 0.56 ECD_01928 phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase 0.66 ECD_00076 2-isopropylmalate synthase low > 60
Escherichia coli BW25113 0.56 b2026 hisI bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) 0.66 b0074 leuA 2-isopropylmalate synthase (NCBI) 0.94 11
Escherichia coli ECOR38 0.56 HEPCGN_03190 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.66 HEPCGN_08695 2-isopropylmalate synthase low > 85
Klebsiella michiganensis M5al 0.55 BWI76_RS18955 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.66 BWI76_RS04680 2-isopropylmalate synthase 0.88 7
Enterobacter asburiae PDN3 0.55 EX28DRAFT_0533 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19)/phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.66 EX28DRAFT_3670 2-isopropylmalate synthase (EC 2.3.3.13) 0.72 47
Dickeya dianthicola 67-19 0.55 HGI48_RS09715 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.66 HGI48_RS18055 2-isopropylmalate synthase low > 71
Dickeya dadantii 3937 0.55 DDA3937_RS09705 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.65 DDA3937_RS18115 2-isopropylmalate synthase 0.76 62
Vibrio cholerae E7946 ATCC 55056 0.55 CSW01_05780 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.71 CSW01_12595 2-isopropylmalate synthase low > 62
Dickeya dianthicola ME23 0.55 DZA65_RS10025 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.66 DZA65_RS19200 2-isopropylmalate synthase 0.82 30
Escherichia coli HS(pFamp)R (ATCC 700891) 0.54 OHPLBJKB_01674 Histidine biosynthesis bifunctional protein HisIE 0.66 OHPLBJKB_03583 2-isopropylmalate synthase low > 73
Escherichia coli ECRC62 0.54 BNILDI_14710 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.66 BNILDI_08550 2-isopropylmalate synthase — —
Escherichia fergusonii Becca 0.51 EFB2_01830 Histidine biosynthesis bifunctional protein HisIE 0.66 EFB2_03971 2-isopropylmalate synthase low > 86
Escherichia coli Nissle 1917 0.51 ECOLIN_RS11975 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.66 ECOLIN_RS00400 2-isopropylmalate synthase — —
Escherichia coli ECRC99 0.51 KEDOAH_03665 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.66 KEDOAH_17440 2-isopropylmalate synthase — —
Escherichia coli ECRC102 0.51 NIAGMN_22430 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.66 NIAGMN_08565 2-isopropylmalate synthase — —
Escherichia coli ECRC101 0.51 MCAODC_20455 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.66 MCAODC_01230 2-isopropylmalate synthase — —
Escherichia coli ECRC101 0.51 OKFHMN_24485 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.66 OKFHMN_10715 2-isopropylmalate synthase — —
Escherichia coli ECRC98 0.51 JDDGAC_28595 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.66 JDDGAC_14310 2-isopropylmalate synthase — —
Escherichia coli ECOR27 0.51 NOLOHH_15800 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.66 NOLOHH_03060 2-isopropylmalate synthase low > 57
Rahnella sp. WP5 0.51 EX31_RS11470 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.69 EX31_RS03680 2-isopropylmalate synthase 0.93 34
Serratia liquefaciens MT49 0.50 IAI46_08180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.69 IAI46_03355 2-isopropylmalate synthase low > 86
Erwinia tracheiphila SCR3 0.49 LU632_RS08915 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.64 LU632_RS02880 leuA 2-isopropylmalate synthase low > 74
Rhodanobacter denitrificans MT42 0.49 LRK55_RS01355 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.40 LRK55_RS09985 2-isopropylmalate synthase low > 63
Dyella japonica UNC79MFTsu3.2 0.49 ABZR86_RS06700 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.42 ABZR86_RS15970 2-isopropylmalate synthase 0.95 14
Rhodanobacter sp. FW510-T8 0.49 OKGIIK_04980 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.39 OKGIIK_13575 leuA 2-isopropylmalate synthase low > 52
Rhodanobacter denitrificans FW104-10B01 0.48 LRK54_RS01575 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.40 LRK54_RS10345 2-isopropylmalate synthase 0.76 20
Xanthomonas campestris pv. campestris strain 8004 0.48 Xcc-8004.2942.1 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.38 Xcc-8004.1056.1 2-isopropylmalate synthase (EC 2.3.3.13) 0.69 23
Parabacteroides merdae CL09T00C40 0.48 HMPREF1078_RS13560 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.44 HMPREF1078_RS16665 2-isopropylmalate synthase 0.94 34
Bacteroides ovatus ATCC 8483 0.47 BACOVA_00218 phosphoribosyl-ATP diphosphatase 0.43 BACOVA_04604 2-isopropylmalate synthase 0.91 46
Pectobacterium carotovorum WPP14 0.47 HER17_RS12260 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.67 HER17_RS03085 2-isopropylmalate synthase 0.96 10
Bacteroides thetaiotaomicron VPI-5482 0.47 BT1377 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (NCBI ptt file) 0.43 BT1861 2-isopropylmalate synthase (EC 2.3.3.13) (from data) 0.94 3
Lysobacter sp. OAE881 0.47 ABIE51_RS13295 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.40 ABIE51_RS17570 2-isopropylmalate synthase low > 62
Bacteroides stercoris CC31F 0.46 HMPREF1181_RS11065 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.43 HMPREF1181_RS14150 2-isopropylmalate synthase 0.91 21
Phocaeicola vulgatus CL09T03C04 0.45 HMPREF1058_RS06180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.43 HMPREF1058_RS14545 2-isopropylmalate synthase 0.93 13
Phocaeicola dorei CL03T12C01 0.45 ABI39_RS19935 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.43 ABI39_RS10195 2-isopropylmalate synthase 0.66 47
Synechococcus elongatus PCC 7942 0.33 Synpcc7942_1995 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein 0.41 Synpcc7942_1410 leuA 2-isopropylmalate synthase — —
Acinetobacter radioresistens SK82 0.27 MPMX26_00264 Histidine biosynthesis bifunctional protein HisIE 0.11 MPMX26_00404 2-isopropylmalate synthase 0.84 32

Not shown: 6 genomes with orthologs for Shewana3_1847 only; 45 genomes with orthologs for Shewana3_3761 only