Conservation of cofitness between b2022 and b2026 in Escherichia coli BW25113

46 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b2022 hisB imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) 1.0 b2026 hisI bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) 0.94 19
Escherichia coli ECRC101 1.00 OKFHMN_24505 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.99 OKFHMN_24485 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECOR27 1.00 NOLOHH_15820 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.92 NOLOHH_15800 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 57
Escherichia coli ECRC102 1.00 NIAGMN_22450 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.99 NIAGMN_22430 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC101 1.00 MCAODC_20435 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.99 MCAODC_20455 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC99 1.00 KEDOAH_03645 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.99 KEDOAH_03665 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC98 1.00 JDDGAC_28615 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.99 JDDGAC_28595 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli BL21 0.99 ECD_01924 histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase 1.00 ECD_01928 phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase low > 60
Escherichia coli ECOR38 0.99 HEPCGN_03210 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.99 HEPCGN_03190 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 85
Escherichia coli HS(pFamp)R (ATCC 700891) 0.99 OHPLBJKB_01678 Histidine biosynthesis bifunctional protein HisB 0.96 OHPLBJKB_01674 Histidine biosynthesis bifunctional protein HisIE low > 73
Escherichia fergusonii Becca 0.99 EFB2_01834 Histidine biosynthesis bifunctional protein HisB 0.98 EFB2_01830 Histidine biosynthesis bifunctional protein HisIE low > 86
Escherichia coli ECRC62 0.99 BNILDI_14730 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.98 BNILDI_14710 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli Nissle 1917 0.99 ECOLIN_RS11955 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.99 ECOLIN_RS11975 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.96 GFF3910 Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) 0.89 GFF3906 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) low > 78
Enterobacter sp. TBS_079 0.92 MPMX20_03004 Histidine biosynthesis bifunctional protein HisB 0.91 MPMX20_03008 Histidine biosynthesis bifunctional protein HisIE 0.94 12
Enterobacter asburiae PDN3 0.91 EX28DRAFT_0537 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) 0.91 EX28DRAFT_0533 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19)/phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.92 11
Klebsiella michiganensis M5al 0.88 BWI76_RS18935 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase 0.87 BWI76_RS18955 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.88 26
Dickeya dadantii 3937 0.84 DDA3937_RS09725 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.81 DDA3937_RS09705 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.96 5
Dickeya dianthicola 67-19 0.84 HGI48_RS09735 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.80 HGI48_RS09715 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 71
Dickeya dianthicola ME23 0.84 DZA65_RS10045 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.80 DZA65_RS10025 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.85 12
Serratia liquefaciens MT49 0.84 IAI46_08200 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.76 IAI46_08180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.88 6
Pectobacterium carotovorum WPP14 0.83 HER17_RS12240 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.70 HER17_RS12260 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.93 40
Rahnella sp. WP5 0.83 EX31_RS11450 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.76 EX31_RS11470 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.93 44
Erwinia tracheiphila SCR3 0.83 LU632_RS08935 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.76 LU632_RS08915 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.95 3
Pantoea sp. MT58 0.82 IAI47_07080 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.81 IAI47_07060 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.98 9
Vibrio cholerae E7946 ATCC 55056 0.68 CSW01_05760 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase 0.64 CSW01_05780 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase low > 62
Shewanella loihica PV-4 0.66 Shew_2200 imidazole glycerol-phosphate dehydratase/histidinol phosphatase (RefSeq) 0.57 Shew_2204 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.96 31
Alteromonas macleodii MIT1002 0.65 MIT1002_02635 Histidine biosynthesis bifunctional protein HisB 0.63 MIT1002_02639 Phosphoribosyl-ATP pyrophosphatase 0.95 35
Shewanella amazonensis SB2B 0.64 Sama_1944 imidazole glycerol-phosphate dehydratase/histidinol phosphatase (RefSeq) 0.61 Sama_1948 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.97 5
Shewanella sp. ANA-3 0.63 Shewana3_1851 imidazole glycerol-phosphate dehydratase/histidinol phosphatase (RefSeq) 0.60 Shewana3_1847 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.95 31
Shewanella oneidensis MR-1 0.63 SO2071 hisB imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase (NCBI ptt file) 0.62 SO2067 hisI phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase (NCBI ptt file) 0.94 32
Lysobacter sp. OAE881 0.54 ABIE51_RS13315 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.47 ABIE51_RS13295 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.83 35
Dyella japonica UNC79MFTsu3.2 0.54 ABZR86_RS06720 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.54 ABZR86_RS06700 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.91 38
Rhodanobacter denitrificans MT42 0.53 LRK55_RS01375 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.56 LRK55_RS01355 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.63 17
Rhodanobacter denitrificans FW104-10B01 0.53 LRK54_RS01595 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.55 LRK54_RS01575 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.79 3
Xanthomonas campestris pv. campestris strain 8004 0.53 Xcc-8004.2946.1 Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) 0.54 Xcc-8004.2942.1 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.85 17
Rhodanobacter sp. FW510-T8 0.52 OKGIIK_04960 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.55 OKGIIK_04980 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 52
Pontibacter actiniarum KMM 6156, DSM 19842 0.47 CA264_05040 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase 0.48 CA264_05115 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase low > 74
Bacteroides thetaiotaomicron VPI-5482 0.46 BT0203 histidine biosynthesis bifunctional protein hisB (NCBI ptt file) 0.51 BT1377 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (NCBI ptt file) 0.88 16
Bacteroides stercoris CC31F 0.46 HMPREF1181_RS04850 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.50 HMPREF1181_RS11065 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.96 4
Bacteroides ovatus ATCC 8483 0.46 BACOVA_01232 histidinol-phosphatase 0.51 BACOVA_00218 phosphoribosyl-ATP diphosphatase 0.98 3
Parabacteroides merdae CL09T00C40 0.45 HMPREF1078_RS02440 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.50 HMPREF1078_RS13560 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.96 34
Echinicola vietnamensis KMM 6221, DSM 17526 0.44 Echvi_2457 histidinol-phosphatase 0.52 Echvi_2517 phosphoribosyl-ATP pyrophosphohydrolase 0.95 6
Phocaeicola vulgatus CL09T03C04 0.44 HMPREF1058_RS15885 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.49 HMPREF1058_RS06180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.94 10
Phocaeicola dorei CL03T12C01 0.44 ABI39_RS11845 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.49 ABI39_RS19935 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.78 40
Mucilaginibacter yixingensis YX-36 DSM 26809 0.43 ABZR88_RS06870 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.54 ABZR88_RS06845 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Pedobacter sp. GW460-11-11-14-LB5 0.42 CA265_RS03625 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase 0.52 CA265_RS03605 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.96 3

Not shown: 0 genomes with orthologs for b2022 only; 3 genomes with orthologs for b2026 only