Conservation of cofitness between b2026 and b2025 in Escherichia coli BW25113

48 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b2026 hisI bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) 1.0 b2025 hisF imidazole glycerol phosphate synthase subunit HisF (NCBI) 0.93 19
Escherichia coli BL21 1.00 ECD_01928 phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase 0.99 ECD_01927 imidazole glycerol phosphate synthase, catalytic subunit with HisH — —
Escherichia coli Nissle 1917 0.99 ECOLIN_RS11975 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 ECOLIN_RS11970 imidazole glycerol phosphate synthase subunit HisF — —
Escherichia coli ECRC98 0.99 JDDGAC_28595 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 JDDGAC_28600 hisF Imidazole glycerol phosphate synthase subunit HisF — —
Escherichia coli ECOR38 0.99 HEPCGN_03190 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.99 HEPCGN_03195 hisF Imidazole glycerol phosphate synthase subunit HisF low > 85
Escherichia coli ECRC101 0.99 MCAODC_20455 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 MCAODC_20450 hisF Imidazole glycerol phosphate synthase subunit HisF — —
Escherichia coli ECRC102 0.99 NIAGMN_22430 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 NIAGMN_22435 hisF Imidazole glycerol phosphate synthase subunit HisF — —
Escherichia coli ECRC101 0.99 OKFHMN_24485 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 OKFHMN_24490 hisF Imidazole glycerol phosphate synthase subunit HisF — —
Escherichia coli ECRC99 0.99 KEDOAH_03665 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 KEDOAH_03660 hisF Imidazole glycerol phosphate synthase subunit HisF — —
Escherichia coli ECRC62 0.98 BNILDI_14710 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 1.00 BNILDI_14715 hisF Imidazole glycerol phosphate synthase subunit HisF — —
Escherichia fergusonii Becca 0.98 EFB2_01830 Histidine biosynthesis bifunctional protein HisIE 1.00 EFB2_01831 Imidazole glycerol phosphate synthase subunit HisF low > 86
Escherichia coli HS(pFamp)R (ATCC 700891) 0.96 OHPLBJKB_01674 Histidine biosynthesis bifunctional protein HisIE 0.99 OHPLBJKB_01675 Imidazole glycerol phosphate synthase subunit HisF low > 73
Escherichia coli ECOR27 0.92 NOLOHH_15800 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.99 NOLOHH_15805 hisF Imidazole glycerol phosphate synthase subunit HisF low > 57
Enterobacter sp. TBS_079 0.91 MPMX20_03008 Histidine biosynthesis bifunctional protein HisIE 0.97 MPMX20_03007 Imidazole glycerol phosphate synthase subunit HisF 0.92 16
Enterobacter asburiae PDN3 0.91 EX28DRAFT_0533 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19)/phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.96 EX28DRAFT_0534 imidazoleglycerol phosphate synthase, cyclase subunit 0.90 16
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.89 GFF3906 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.95 GFF3907 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) low > 78
Klebsiella michiganensis M5al 0.87 BWI76_RS18955 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.96 BWI76_RS18950 imidazole glycerol phosphate synthase cyclase subunit 0.85 34
Dickeya dadantii 3937 0.81 DDA3937_RS09705 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.93 DDA3937_RS09710 imidazole glycerol phosphate synthase subunit HisF 0.95 8
Pantoea sp. MT58 0.81 IAI47_07060 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.90 IAI47_07065 imidazole glycerol phosphate synthase subunit HisF 0.98 2
Dickeya dianthicola 67-19 0.80 HGI48_RS09715 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.92 HGI48_RS09720 imidazole glycerol phosphate synthase subunit HisF — —
Dickeya dianthicola ME23 0.80 DZA65_RS10025 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.92 DZA65_RS10030 imidazole glycerol phosphate synthase subunit HisF 0.86 16
Erwinia tracheiphila SCR3 0.76 LU632_RS08915 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.93 LU632_RS08920 hisF imidazole glycerol phosphate synthase subunit HisF 0.93 4
Rahnella sp. WP5 0.76 EX31_RS11470 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.91 EX31_RS11465 imidazole glycerol phosphate synthase subunit HisF 0.95 15
Serratia liquefaciens MT49 0.76 IAI46_08180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.95 IAI46_08185 imidazole glycerol phosphate synthase subunit HisF 0.91 6
Pectobacterium carotovorum WPP14 0.70 HER17_RS12260 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.91 HER17_RS12255 imidazole glycerol phosphate synthase subunit HisF 0.92 42
Vibrio cholerae E7946 ATCC 55056 0.64 CSW01_05780 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.87 CSW01_05775 imidazole glycerol phosphate synthase cyclase subunit low > 62
Alteromonas macleodii MIT1002 0.63 MIT1002_02639 Phosphoribosyl-ATP pyrophosphatase 0.76 MIT1002_02638 Imidazole glycerol phosphate synthase subunit HisF 0.90 48
Shewanella oneidensis MR-1 0.62 SO2067 hisI phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase (NCBI ptt file) 0.75 SO2068 hisF hisF protein (cyclase) (NCBI ptt file) 0.95 3
Shewanella amazonensis SB2B 0.61 Sama_1948 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.77 Sama_1947 imidazole glycerol phosphate synthase subunit HisF (RefSeq) 0.97 4
Shewanella sp. ANA-3 0.60 Shewana3_1847 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.75 Shewana3_1848 imidazole glycerol phosphate synthase subunit HisF (RefSeq) 0.92 19
Shewanella loihica PV-4 0.57 Shew_2204 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (RefSeq) 0.75 Shew_2203 imidazole glycerol phosphate synthase subunit HisF (RefSeq) 0.95 27
Rhodanobacter denitrificans MT42 0.56 LRK55_RS01355 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.64 LRK55_RS01360 imidazole glycerol phosphate synthase subunit HisF low > 63
Rhodanobacter denitrificans FW104-10B01 0.55 LRK54_RS01575 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.65 LRK54_RS01580 imidazole glycerol phosphate synthase subunit HisF low > 59
Rhodanobacter sp. FW510-T8 0.55 OKGIIK_04980 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.64 OKGIIK_04975 hisF imidazole glycerol phosphate synthase subunit HisF low > 52
Dyella japonica UNC79MFTsu3.2 0.54 ABZR86_RS06700 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.63 ABZR86_RS06705 imidazole glycerol phosphate synthase subunit HisF 0.94 19
Mucilaginibacter yixingensis YX-36 DSM 26809 0.54 ABZR88_RS06845 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.43 ABZR88_RS06855 imidazole glycerol phosphate synthase subunit HisF — —
Xanthomonas campestris pv. campestris strain 8004 0.54 Xcc-8004.2942.1 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.63 Xcc-8004.2943.1 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) 0.81 7
Echinicola vietnamensis KMM 6221, DSM 17526 0.52 Echvi_2517 phosphoribosyl-ATP pyrophosphohydrolase 0.41 Echvi_2516 imidazoleglycerol phosphate synthase, cyclase subunit 0.95 3
Bacteroides ovatus ATCC 8483 0.51 BACOVA_00218 phosphoribosyl-ATP diphosphatase 0.44 BACOVA_00219 imidazoleglycerol phosphate synthase, cyclase subunit 0.98 2
Bacteroides thetaiotaomicron VPI-5482 0.51 BT1377 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (NCBI ptt file) 0.44 BT1378 imidazole glycerol phosphate synthase subunit hisF (NCBI ptt file) 0.83 35
Bacteroides stercoris CC31F 0.50 HMPREF1181_RS11065 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.42 HMPREF1181_RS11070 imidazole glycerol phosphate synthase subunit HisF 0.94 7
Parabacteroides merdae CL09T00C40 0.50 HMPREF1078_RS13560 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.43 HMPREF1078_RS13565 imidazole glycerol phosphate synthase subunit HisF 0.94 29
Phocaeicola vulgatus CL09T03C04 0.49 HMPREF1058_RS06180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.46 HMPREF1058_RS06175 imidazole glycerol phosphate synthase subunit HisF 0.95 5
Phocaeicola dorei CL03T12C01 0.49 ABI39_RS19935 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.46 ABI39_RS19930 imidazole glycerol phosphate synthase subunit HisF 0.72 25
Pontibacter actiniarum KMM 6156, DSM 19842 0.48 CA264_05115 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.47 CA264_05110 imidazole glycerol phosphate synthase cyclase subunit low > 74
Lysobacter sp. OAE881 0.47 ABIE51_RS13295 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.65 ABIE51_RS13300 imidazole glycerol phosphate synthase subunit HisF low > 62
Brevundimonas sp. GW460-12-10-14-LB2 0.46 A4249_RS10720 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.57 A4249_RS10715 imidazole glycerol phosphate synthase subunit HisF 1.00 3
Synechococcus elongatus PCC 7942 0.35 Synpcc7942_1995 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein 0.37 Synpcc7942_2087 hisF imidazole glycerol phosphate synthase subunit HisF — —
Acinetobacter radioresistens SK82 0.31 MPMX26_00264 Histidine biosynthesis bifunctional protein HisIE 0.40 MPMX26_02854 Imidazole glycerol phosphate synthase subunit HisF 0.97 11

Not shown: 1 genomes with orthologs for b2026 only; 53 genomes with orthologs for b2025 only