Conservation of cofitness between b0386 and b2022 in Escherichia coli BW25113

46 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b0386 proC pyrroline-5-carboxylate reductase (NCBI) 1.0 b2022 hisB imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) 0.87 13
Escherichia coli BL21 1.00 ECD_00333 pyrroline-5-carboxylate reductase, NAD(P)-binding 0.99 ECD_01924 histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase low > 60
Escherichia coli ECOR38 1.00 HEPCGN_07250 proC pyrroline-5-carboxylate reductase 0.99 HEPCGN_03210 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB low > 85
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_03288 Pyrroline-5-carboxylate reductase 0.99 OHPLBJKB_01678 Histidine biosynthesis bifunctional protein HisB low > 73
Escherichia coli ECRC62 1.00 BNILDI_22950 proC pyrroline-5-carboxylate reductase 0.99 BNILDI_14730 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB — —
Escherichia coli Nissle 1917 1.00 ECOLIN_RS02345 pyrroline-5-carboxylate reductase 0.99 ECOLIN_RS11955 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB — —
Escherichia coli ECOR27 1.00 NOLOHH_01535 proC pyrroline-5-carboxylate reductase 1.00 NOLOHH_15820 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB low > 57
Escherichia coli ECRC102 1.00 NIAGMN_06665 proC pyrroline-5-carboxylate reductase 1.00 NIAGMN_22450 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB — —
Escherichia coli ECRC99 1.00 KEDOAH_19355 proC pyrroline-5-carboxylate reductase 1.00 KEDOAH_03645 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB — —
Escherichia coli ECRC101 1.00 MCAODC_27835 proC pyrroline-5-carboxylate reductase 1.00 MCAODC_20435 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB — —
Escherichia coli ECRC101 1.00 OKFHMN_08610 proC pyrroline-5-carboxylate reductase 1.00 OKFHMN_24505 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB — —
Escherichia coli ECRC98 1.00 JDDGAC_12265 proC pyrroline-5-carboxylate reductase 1.00 JDDGAC_28615 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB — —
Escherichia fergusonii Becca 0.99 EFB2_03670 Pyrroline-5-carboxylate reductase 0.99 EFB2_01834 Histidine biosynthesis bifunctional protein HisB low > 86
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.97 GFF4283 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) 0.96 GFF3910 Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) low > 78
Klebsiella michiganensis M5al 0.94 BWI76_RS06170 pyrroline-5-carboxylate reductase 0.88 BWI76_RS18935 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase — —
Enterobacter sp. TBS_079 0.93 MPMX20_00976 Pyrroline-5-carboxylate reductase 0.92 MPMX20_03004 Histidine biosynthesis bifunctional protein HisB 0.91 6
Enterobacter asburiae PDN3 0.93 EX28DRAFT_2585 pyrroline-5-carboxylate reductase 0.91 EX28DRAFT_0537 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) 0.62 38
Erwinia tracheiphila SCR3 0.71 LU632_RS18995 proC pyrroline-5-carboxylate reductase 0.83 LU632_RS08935 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.62 24
Pantoea sp. MT58 0.64 IAI47_14945 pyrroline-5-carboxylate reductase 0.82 IAI47_07080 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.84 16
Lysobacter sp. OAE881 0.30 ABIE51_RS16065 pyrroline-5-carboxylate reductase 0.54 ABIE51_RS13315 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB low > 62
Dyella japonica UNC79MFTsu3.2 0.29 ABZR86_RS10425 pyrroline-5-carboxylate reductase 0.54 ABZR86_RS06720 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.85 60
Shewanella loihica PV-4 0.29 Shew_1136 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data) 0.66 Shew_2200 imidazole glycerol-phosphate dehydratase/histidinol phosphatase (RefSeq) 0.95 5
Shewanella amazonensis SB2B 0.29 Sama_2478 pyrroline-5-carboxylate reductase (RefSeq) 0.64 Sama_1944 imidazole glycerol-phosphate dehydratase/histidinol phosphatase (RefSeq) 0.93 33
Alteromonas macleodii MIT1002 0.28 MIT1002_03062 Pyrroline-5-carboxylate reductase 0.65 MIT1002_02635 Histidine biosynthesis bifunctional protein HisB 0.96 18
Pectobacterium carotovorum WPP14 0.28 HER17_RS03805 pyrroline-5-carboxylate reductase 0.83 HER17_RS12240 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB — —
Shewanella oneidensis MR-1 0.28 SO3354 proC pyrroline-5-carboxylate reductase (NCBI ptt file) 0.63 SO2071 hisB imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase (NCBI ptt file) 0.97 16
Dickeya dadantii 3937 0.28 DDA3937_RS17305 pyrroline-5-carboxylate reductase 0.84 DDA3937_RS09725 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.72 16
Rhodanobacter denitrificans FW104-10B01 0.27 LRK54_RS04260 pyrroline-5-carboxylate reductase 0.53 LRK54_RS01595 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.58 51
Rhodanobacter denitrificans MT42 0.27 LRK55_RS04030 pyrroline-5-carboxylate reductase 0.53 LRK55_RS01375 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB — —
Rhodanobacter sp. FW510-T8 0.27 OKGIIK_11135 proC pyrroline-5-carboxylate reductase 0.52 OKGIIK_04960 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB low > 52
Vibrio cholerae E7946 ATCC 55056 0.27 CSW01_02450 pyrroline-5-carboxylate reductase 0.68 CSW01_05760 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase low > 62
Shewanella sp. ANA-3 0.27 Shewana3_1193 pyrroline-5-carboxylate reductase (RefSeq) 0.63 Shewana3_1851 imidazole glycerol-phosphate dehydratase/histidinol phosphatase (RefSeq) 0.96 4
Dickeya dianthicola 67-19 0.26 HGI48_RS17350 pyrroline-5-carboxylate reductase 0.84 HGI48_RS09735 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB — —
Serratia liquefaciens MT49 0.26 IAI46_21415 pyrroline-5-carboxylate reductase 0.84 IAI46_08200 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB low > 86
Dickeya dianthicola ME23 0.26 DZA65_RS18440 pyrroline-5-carboxylate reductase 0.84 DZA65_RS10045 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB — —
Rahnella sp. WP5 0.26 EX31_RS02690 pyrroline-5-carboxylate reductase 0.83 EX31_RS11450 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.95 34
Phocaeicola vulgatus CL09T03C04 0.25 HMPREF1058_RS08830 pyrroline-5-carboxylate reductase 0.44 HMPREF1058_RS15885 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.94 13
Phocaeicola dorei CL03T12C01 0.25 ABI39_RS02960 pyrroline-5-carboxylate reductase 0.44 ABI39_RS11845 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.81 20
Xanthomonas campestris pv. campestris strain 8004 0.24 Xcc-8004.1710.1 Pyrroline-5-carboxylate reductase (EC 1.5.1.2) 0.53 Xcc-8004.2946.1 Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) 0.66 8
Bacteroides thetaiotaomicron VPI-5482 0.23 BT3757 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data) 0.46 BT0203 histidine biosynthesis bifunctional protein hisB (NCBI ptt file) 0.85 29
Bacteroides stercoris CC31F 0.22 HMPREF1181_RS03440 pyrroline-5-carboxylate reductase 0.46 HMPREF1181_RS04850 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.94 19
Bacteroides ovatus ATCC 8483 0.22 BACOVA_03587 pyrroline-5-carboxylate reductase 0.46 BACOVA_01232 histidinol-phosphatase 0.85 48
Pontibacter actiniarum KMM 6156, DSM 19842 0.21 CA264_07730 pyrroline-5-carboxylate reductase 0.47 CA264_05040 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase low > 74
Echinicola vietnamensis KMM 6221, DSM 17526 0.20 Echvi_2479 pyrroline-5-carboxylate reductase 0.44 Echvi_2457 histidinol-phosphatase 0.73 36
Mucilaginibacter yixingensis YX-36 DSM 26809 0.19 ABZR88_RS09865 pyrroline-5-carboxylate reductase 0.43 ABZR88_RS06870 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.81 16
Parabacteroides merdae CL09T00C40 0.18 HMPREF1078_RS10620 pyrroline-5-carboxylate reductase 0.45 HMPREF1078_RS02440 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.96 14
Pedobacter sp. GW460-11-11-14-LB5 0.18 CA265_RS18505 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data) 0.42 CA265_RS03625 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase 0.91 36

Not shown: 54 genomes with orthologs for b0386 only; 0 genomes with orthologs for b2022 only