Conservation of cofitness between b2022 and b0072 in Escherichia coli BW25113

46 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b2022 hisB imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) 1.0 b0072 leuC isopropylmalate isomerase large subunit (NCBI) 0.96 10
Escherichia coli ECRC98 1.00 JDDGAC_28615 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 JDDGAC_14320 leuC1 3-isopropylmalate dehydratase large subunit 1 — —
Escherichia coli ECRC99 1.00 KEDOAH_03645 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 KEDOAH_17430 leuC1 3-isopropylmalate dehydratase large subunit 1 — —
Escherichia coli ECOR27 1.00 NOLOHH_15820 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 NOLOHH_03070 leuC1 3-isopropylmalate dehydratase large subunit 1 low > 57
Escherichia coli ECRC102 1.00 NIAGMN_22450 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 NIAGMN_08575 leuC1 3-isopropylmalate dehydratase large subunit 1 — —
Escherichia coli ECRC101 1.00 MCAODC_20435 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 MCAODC_01240 leuC1 3-isopropylmalate dehydratase large subunit 1 — —
Escherichia coli ECRC101 1.00 OKFHMN_24505 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 OKFHMN_10725 leuC1 3-isopropylmalate dehydratase large subunit 1 — —
Escherichia coli HS(pFamp)R (ATCC 700891) 0.99 OHPLBJKB_01678 Histidine biosynthesis bifunctional protein HisB 1.00 OHPLBJKB_03585 3-isopropylmalate dehydratase large subunit low > 73
Escherichia coli BL21 0.99 ECD_01924 histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase 1.00 ECD_00074 3-isopropylmalate dehydratase large subunit 0.59 12
Escherichia coli ECOR38 0.99 HEPCGN_03210 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 HEPCGN_08705 leuC1 3-isopropylmalate dehydratase large subunit 1 low > 85
Escherichia fergusonii Becca 0.99 EFB2_01834 Histidine biosynthesis bifunctional protein HisB 1.00 EFB2_03973 3-isopropylmalate dehydratase large subunit low > 86
Escherichia coli ECRC62 0.99 BNILDI_14730 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 BNILDI_08540 leuC1 3-isopropylmalate dehydratase large subunit 1 — —
Escherichia coli Nissle 1917 0.99 ECOLIN_RS11955 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 ECOLIN_RS00390 3-isopropylmalate dehydratase large subunit — —
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.96 GFF3910 Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) 0.94 GFF166 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) low > 78
Enterobacter sp. TBS_079 0.92 MPMX20_03004 Histidine biosynthesis bifunctional protein HisB 0.94 MPMX20_00767 3-isopropylmalate dehydratase large subunit 1 0.93 18
Enterobacter asburiae PDN3 0.91 EX28DRAFT_0537 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) 0.95 EX28DRAFT_3668 3-isopropylmalate dehydratase, large subunit 0.94 5
Klebsiella michiganensis M5al 0.88 BWI76_RS18935 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase 0.95 BWI76_RS04670 3-isopropylmalate dehydratase large subunit 0.89 22
Dickeya dadantii 3937 0.84 DDA3937_RS09725 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.85 DDA3937_RS18125 3-isopropylmalate dehydratase large subunit 0.73 72
Dickeya dianthicola 67-19 0.84 HGI48_RS09735 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.85 HGI48_RS18065 3-isopropylmalate dehydratase large subunit low > 71
Dickeya dianthicola ME23 0.84 DZA65_RS10045 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.85 DZA65_RS19210 3-isopropylmalate dehydratase large subunit 0.69 43
Serratia liquefaciens MT49 0.84 IAI46_08200 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.86 IAI46_03345 3-isopropylmalate dehydratase large subunit low > 86
Pectobacterium carotovorum WPP14 0.83 HER17_RS12240 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.86 HER17_RS03075 3-isopropylmalate dehydratase large subunit 0.96 23
Rahnella sp. WP5 0.83 EX31_RS11450 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.87 EX31_RS03690 3-isopropylmalate dehydratase large subunit 0.97 3
Erwinia tracheiphila SCR3 0.83 LU632_RS08935 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.79 LU632_RS02870 leuC 3-isopropylmalate dehydratase large subunit 0.78 25
Pantoea sp. MT58 0.82 IAI47_07080 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.87 IAI47_16010 3-isopropylmalate dehydratase large subunit 0.97 16
Vibrio cholerae E7946 ATCC 55056 0.68 CSW01_05760 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase 0.80 CSW01_12605 3-isopropylmalate dehydratase large subunit low > 62
Shewanella loihica PV-4 0.66 Shew_2200 imidazole glycerol-phosphate dehydratase/histidinol phosphatase (RefSeq) 0.71 Shew_3470 isopropylmalate isomerase large subunit (RefSeq) 0.99 3
Alteromonas macleodii MIT1002 0.65 MIT1002_02635 Histidine biosynthesis bifunctional protein HisB 0.69 MIT1002_00947 3-isopropylmalate dehydratase large subunit 0.96 29
Shewanella amazonensis SB2B 0.64 Sama_1944 imidazole glycerol-phosphate dehydratase/histidinol phosphatase (RefSeq) 0.72 Sama_0337 isopropylmalate isomerase large subunit (RefSeq) 0.94 20
Shewanella sp. ANA-3 0.63 Shewana3_1851 imidazole glycerol-phosphate dehydratase/histidinol phosphatase (RefSeq) 0.73 Shewana3_3759 isopropylmalate isomerase large subunit (RefSeq) 0.96 14
Shewanella oneidensis MR-1 0.63 SO2071 hisB imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase (NCBI ptt file) 0.73 SO4234 leuC 3-isopropylmalate dehydratase, large subunit (NCBI ptt file) 0.97 14
Lysobacter sp. OAE881 0.54 ABIE51_RS13315 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.53 ABIE51_RS17575 3-isopropylmalate dehydratase large subunit 0.86 7
Dyella japonica UNC79MFTsu3.2 0.54 ABZR86_RS06720 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.51 ABZR86_RS15960 3-isopropylmalate dehydratase large subunit 0.93 13
Rhodanobacter denitrificans MT42 0.53 LRK55_RS01375 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.54 LRK55_RS07105 3-isopropylmalate dehydratase large subunit low > 63
Rhodanobacter denitrificans FW104-10B01 0.53 LRK54_RS01595 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.54 LRK54_RS07375 3-isopropylmalate dehydratase large subunit low > 59
Xanthomonas campestris pv. campestris strain 8004 0.53 Xcc-8004.2946.1 Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) 0.63 Xcc-8004.1049.1 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) 0.92 8
Rhodanobacter sp. FW510-T8 0.52 OKGIIK_04960 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.49 OKGIIK_13585 leuC 3-isopropylmalate dehydratase large subunit low > 52
Pontibacter actiniarum KMM 6156, DSM 19842 0.47 CA264_05040 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase 0.54 CA264_09435 3-isopropylmalate dehydratase large subunit low > 74
Bacteroides thetaiotaomicron VPI-5482 0.46 BT0203 histidine biosynthesis bifunctional protein hisB (NCBI ptt file) 0.51 BT1860 3-isopropylmalate dehydratase large subunit (NCBI ptt file) 0.83 35
Bacteroides stercoris CC31F 0.46 HMPREF1181_RS04850 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.52 HMPREF1181_RS14145 3-isopropylmalate dehydratase large subunit 0.91 23
Bacteroides ovatus ATCC 8483 0.46 BACOVA_01232 histidinol-phosphatase 0.52 BACOVA_04603 3-isopropylmalate dehydratase, large subunit 0.95 20
Parabacteroides merdae CL09T00C40 0.45 HMPREF1078_RS02440 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.50 HMPREF1078_RS16660 3-isopropylmalate dehydratase large subunit 0.96 35
Echinicola vietnamensis KMM 6221, DSM 17526 0.44 Echvi_2457 histidinol-phosphatase 0.54 Echvi_2059 3-isopropylmalate dehydratase, large subunit 0.65 50
Phocaeicola vulgatus CL09T03C04 0.44 HMPREF1058_RS15885 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.51 HMPREF1058_RS14550 3-isopropylmalate dehydratase large subunit 0.85 26
Phocaeicola dorei CL03T12C01 0.44 ABI39_RS11845 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.51 ABI39_RS10200 3-isopropylmalate dehydratase large subunit 0.83 21
Mucilaginibacter yixingensis YX-36 DSM 26809 0.43 ABZR88_RS06870 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.58 ABZR88_RS11595 3-isopropylmalate dehydratase large subunit — —
Pedobacter sp. GW460-11-11-14-LB5 0.42 CA265_RS03625 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase 0.57 CA265_RS15830 3-isopropylmalate dehydratase large subunit 0.92 22

Not shown: 0 genomes with orthologs for b2022 only; 56 genomes with orthologs for b0072 only