Conservation of cofitness between HEPCGN_02885 and HEPCGN_05520 in Escherichia coli ECOR38

31 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli ECOR38 1.0 HEPCGN_02885 mdtB multidrug efflux RND transporter permease subunit MdtB 1.0 HEPCGN_05520 hydroxyacid dehydrogenase 0.65 8
Klebsiella michiganensis M5al 0.90 BWI76_RS19255 multidrug transporter subunit MdtB 0.37 BWI76_RS27925 D-isomer specific 2-hydroxyacid dehydrogenase low > 92
Serratia liquefaciens MT49 0.81 IAI46_18975 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.40 IAI46_12780 2-hydroxyacid dehydrogenase low > 86
Herbaspirillum seropedicae SmR1 0.68 HSERO_RS07650 multidrug transporter 0.45 HSERO_RS19280 D-2-hydroxyacid dehydrogenase low > 78
Ralstonia solanacearum IBSBF1503 0.65 RALBFv3_RS18120 multidrug transporter subunit MdtB 0.31 RALBFv3_RS21225 2-hydroxyacid dehydrogenase low > 76
Ralstonia solanacearum UW163 0.65 UW163_RS21010 multidrug transporter subunit MdtB 0.31 UW163_RS22370 2-hydroxyacid dehydrogenase — —
Ralstonia solanacearum PSI07 0.65 RPSI07_RS05515 multidrug transporter subunit MdtB 0.31 RPSI07_RS01915 2-hydroxyacid dehydrogenase low > 81
Ralstonia sp. UNC404CL21Col 0.65 ABZR87_RS19025 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.30 ABZR87_RS21670 2-hydroxyacid dehydrogenase low > 80
Ralstonia solanacearum GMI1000 0.65 RS_RS22915 multidrug transporter subunit MdtB 0.32 RS_RS19585 2-hydroxyacid dehydrogenase low > 80
Cupriavidus basilensis FW507-4G11 0.64 RR42_RS03310 multidrug transporter 0.44 RR42_RS33330 hydroxyacid dehydrogenase low > 128
Pseudomonas sp. RS175 0.62 PFR28_02194 Multidrug resistance protein MdtB 0.32 PFR28_02378 2-ketogluconate reductase low > 88
Pseudomonas fluorescens FW300-N2C3 0.62 AO356_25875 multidrug transporter 0.33 AO356_20675 dihydrofolate reductase low > 104
Rahnella sp. WP5 0.62 EX31_RS13380 MMPL family transporter 0.41 EX31_RS10310 2-hydroxyacid dehydrogenase low > 89
Pseudomonas fluorescens FW300-N2E2 0.62 Pf6N2E2_1272 Acriflavin resistance plasma membrane protein 0.34 Pf6N2E2_562 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) low > 103
Pseudomonas putida KT2440 0.62 PP_3584 multidrug efflux transport system - membrane subunit 0.34 PP_1707 D-isomer specific 2-hydroxyacid dehydrogenase family protein low > 96
Pseudomonas fluorescens GW456-L13 0.62 PfGW456L13_3266 Acriflavin resistance plasma membrane protein 0.32 PfGW456L13_3497 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) low > 87
Pseudomonas fluorescens FW300-N2E3 0.62 AO353_22895 multidrug transporter 0.31 AO353_21585 hydroxyacid dehydrogenase low > 101
Pseudomonas fluorescens SBW25 0.61 PFLU_RS13430 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.31 PFLU_RS17035 2-hydroxyacid dehydrogenase low > 109
Pseudomonas fluorescens SBW25-INTG 0.61 PFLU_RS13430 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.31 PFLU_RS17035 2-hydroxyacid dehydrogenase low > 109
Pseudomonas simiae WCS417 0.61 PS417_12745 multidrug transporter 0.32 PS417_15020 2-hydroxyacid dehydrogenase low > 88
Paraburkholderia sabiae LMG 24235 0.60 QEN71_RS23305 MdtB/MuxB family multidrug efflux RND transporter permease subunit 0.33 QEN71_RS08140 2-hydroxyacid dehydrogenase low > 153
Paraburkholderia bryophila 376MFSha3.1 0.59 H281DRAFT_06492 multidrug efflux pump 0.36 H281DRAFT_06500 Lactate dehydrogenase low > 103
Acidovorax sp. GW101-3H11 0.59 Ac3H11_3618 Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA 0.43 Ac3H11_2341 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) low > 79
Pseudomonas syringae pv. syringae B728a ΔmexB 0.59 Psyr_2483 Acriflavin resistance protein 0.34 Psyr_3241 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein low > 86
Pseudomonas syringae pv. syringae B728a 0.59 Psyr_2483 Acriflavin resistance protein 0.34 Psyr_3241 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein low > 86
Pseudomonas stutzeri RCH2 0.59 Psest_2139 Cation/multidrug efflux pump 0.41 Psest_0378 Lactate dehydrogenase and related dehydrogenases low > 67
Burkholderia phytofirmans PsJN 0.58 BPHYT_RS07785 multidrug transporter 0.34 BPHYT_RS24525 2-hydroxyacid dehydrogenase low > 109
Paraburkholderia graminis OAS925 0.58 ABIE53_001783 multidrug efflux pump 0.34 ABIE53_002237 hydroxypyruvate reductase — —
Castellaniella sp019104865 MT123 0.57 ABCV34_RS14620 multidrug efflux RND transporter permease subunit 0.39 ABCV34_RS07780 2-hydroxyacid dehydrogenase low > 48
Variovorax sp. SCN45 0.56 GFF6659 Multidrug efflux system MdtABC-TolC, inner-membrane proton/drug antiporter MdtB (RND type) 0.41 GFF5778 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) low > 127
Variovorax sp. OAS795 0.54 ABID97_RS20855 efflux RND transporter permease subunit 0.42 ABID97_RS01195 2-hydroxyacid dehydrogenase low > 91
Azospirillum sp. SherDot2 0.53 MPMX19_05477 Multidrug resistance protein MdtB 0.40 MPMX19_05876 2-ketogluconate reductase low > 112

Not shown: 33 genomes with orthologs for HEPCGN_02885 only; 9 genomes with orthologs for HEPCGN_05520 only