| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_00655 | | 2-haloalkanoic acid dehalogenase | 1.0 | CSW01_01545 | | hybrid sensor histidine kinase/response regulator | 0.62 | 16 |
| Shewanella loihica PV-4 | 0.35 | Shew_0326 | | HAD family hydrolase (RefSeq) | 0.40 | Shew_1534 | | integral membrane sensor hybrid histidine kinase (RefSeq) | low | > 60 |
| Shewanella oneidensis MR-1 | 0.32 | SO4305 | | HAD-superfamily hydrolase, subfamily IA, variant 1 family protein (NCBI ptt file) | 0.41 | SO2742 | | sensor histidine kinase/response regulator (NCBI ptt file) | low | > 76 |
| Shewanella amazonensis SB2B | 0.32 | Sama_3246 | | HAD-superfamily hydrolase, subfamily IA, variant 1 family protein (RefSeq) | 0.40 | Sama_2078 | | sensor histidine kinase/response regulator (RefSeq) | low | > 62 |
| Pseudomonas fluorescens SBW25 | 0.31 | PFLU_RS29285 | | HAD-IA family hydrolase | 0.47 | PFLU_RS21935 | | sensor histidine kinase | low | > 109 |
| Pseudomonas fluorescens SBW25-INTG | 0.31 | PFLU_RS29285 | | HAD-IA family hydrolase | 0.47 | PFLU_RS21935 | | sensor histidine kinase | low | > 109 |
| Shewanella sp. ANA-3 | 0.31 | Shewana3_0394 | | HAD family hydrolase (RefSeq) | 0.40 | Shewana3_2522 | | multi-sensor hybrid histidine kinase (RefSeq) | low | > 73 |
| Pseudomonas lactucae CFBP13502 | 0.31 | GEMAOFIL_05658 | | 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB | 0.47 | GEMAOFIL_04190 | | Sensor histidine kinase RcsC | low | > 93 |
| Pseudomonas simiae WCS417 | 0.30 | PS417_27600 | | HAD family hydrolase | 0.47 | PS417_19965 | | histidine kinase | low | > 88 |
| Pseudomonas fluorescens GW456-L13 | 0.29 | PfGW456L13_841 | | Putative FMN hydrolase (EC 3.1.3.-); 5-Amino-6-(5'-phosphoribitylamino)uracil phosphatase | 0.47 | PfGW456L13_4223 | | Sensory box histidine kinase/response regulator | low | > 87 |
| Pseudomonas sp. DMC3 | 0.29 | GFF371 | | 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB | 0.47 | GFF2567 | | Sensor histidine kinase RcsC | low | > 89 |
| Pseudomonas sp. SVBP6 | 0.29 | COO64_RS01275 | | HAD family hydrolase | 0.47 | COO64_RS07150 | | PAS domain-containing hybrid sensor histidine kinase/response regulator | low | > 93 |
| Pseudomonas sp. BP01 | 0.29 | JOY50_RS22615 | | HAD family hydrolase | 0.46 | JOY50_RS28040 | | hybrid sensor histidine kinase/response regulator | low | > 84 |
| Pseudomonas putida KT2440 | 0.28 | PP_5231 | | putative (S)-2-haloacid dehalogenase | 0.46 | PP_1695 | | putative Sodium-solute symporter/sensory box histidine kinase/response regulator | low | > 96 |
| Alteromonas macleodii MIT1002 | 0.28 | MIT1002_00156 | | Flavin mononucleotide phosphatase YigB | 0.31 | MIT1002_03509 | | Aerobic respiration control sensor protein ArcB | low | > 70 |
| Pseudomonas fluorescens FW300-N2E3 | 0.28 | AO353_09055 | | HAD family hydrolase | 0.47 | AO353_02555 | | histidine kinase | low | > 101 |
| Pseudomonas aeruginosa PA14 | 0.27 | IKLFDK_27045 | | HAD family hydrolase | 0.47 | IKLFDK_16750 | | hybrid sensor histidine kinase/response regulator | low | > 100 |
| Lysobacter sp. OAE881 | 0.27 | ABIE51_RS03240 | | HAD-IA family hydrolase | 0.36 | ABIE51_RS01675 | | PAS domain-containing hybrid sensor histidine kinase/response regulator | low | > 62 |
| Pseudomonas fluorescens FW300-N2C3 | 0.27 | AO356_12720 | | HAD family hydrolase | 0.47 | AO356_19225 | | histidine kinase | low | > 104 |
| Pseudomonas fluorescens FW300-N2E2 | 0.27 | Pf6N2E2_4415 | | Putative FMN hydrolase (EC 3.1.3.-); 5-Amino-6-(5'-phosphoribitylamino)uracil phosphatase | 0.47 | Pf6N2E2_5760 | | Sensory box histidine kinase/response regulator | low | > 103 |
| Pseudomonas syringae pv. syringae B728a | 0.27 | Psyr_0186 | | HAD-superfamily hydrolase, subfamily IA, variant 3:HAD-superfamily hydrolase, subfamily IA, variant 1 | 0.45 | Psyr_1585 | | Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase A, N-terminal | low | > 86 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.27 | Psyr_0186 | | HAD-superfamily hydrolase, subfamily IA, variant 3:HAD-superfamily hydrolase, subfamily IA, variant 1 | 0.45 | Psyr_1585 | | Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase A, N-terminal | low | > 86 |
| Pseudomonas sp. RS175 | 0.27 | PFR28_04379 | | 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB | 0.47 | PFR28_03189 | | Sensor histidine kinase RcsC | low | > 88 |
| Pseudomonas stutzeri RCH2 | 0.26 | Psest_3768 | | haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED/haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E | 0.47 | Psest_1527 | | Na+/proline symporter | low | > 67 |
| Xanthomonas campestris pv. campestris strain 8004 | 0.26 | Xcc-8004.4953.1 | | Putative FMN hydrolase (EC 3.1.3.-); 5-Amino-6-(5'-phosphoribitylamino)uracil phosphatase | 0.36 | Xcc-8004.5181.1 | | Sensor histidine kinase | low | > 74 |
| Pseudomonas sp. S08-1 | 0.26 | OH686_13780 | | 2-haloalkanoic acid dehalogenase | 0.46 | OH686_19595 | | Two-component system sensor histidine kinase | 0.62 | 10 |
| Pseudomonas segetis P6 | 0.26 | MPMX49_04537 | | 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB | 0.47 | MPMX49_01727 | | Sensor histidine kinase RcsC | low | > 75 |
| Rhodanobacter sp. FW510-T8 | 0.23 | OKGIIK_00140 | yigB | HAD family hydrolase | 0.37 | OKGIIK_15210 | ompR | DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain | low | > 52 |
| Rhodanobacter denitrificans MT42 | 0.23 | LRK55_RS06185 | | HAD family hydrolase | 0.37 | LRK55_RS08195 | | PAS domain-containing hybrid sensor histidine kinase/response regulator | low | > 63 |
| Rhodanobacter denitrificans FW104-10B01 | 0.23 | LRK54_RS06440 | | HAD family hydrolase | 0.37 | LRK54_RS08430 | | hybrid sensor histidine kinase/response regulator | low | > 59 |
| Rhodanobacter sp000427505 FW510-R12 | 0.23 | LRK53_RS17730 | | HAD family hydrolase | 0.37 | LRK53_RS00060 | | hybrid sensor histidine kinase/response regulator | low | > 59 |
| Dyella japonica UNC79MFTsu3.2 | 0.21 | ABZR86_RS17535 | | HAD family hydrolase | 0.37 | ABZR86_RS15190 | | PAS domain-containing hybrid sensor histidine kinase/response regulator | low | > 74 |
Not shown: 35 genomes with orthologs for CSW01_00655 only; 11 genomes with orthologs for CSW01_01545 only