| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
|---|
| Brevundimonas sp. GW460-12-10-14-LB2 | 1.0 | A4249_RS15630 | | sensor histidine kinase KdpD | 1.0 | A4249_RS11115 | | MFS transporter | 0.43 | 17 |
| Caulobacter crescentus NA1000 | 0.66 | CCNA_01666 | | osmosensitive K+ channel histidine kinase kdpD | 0.48 | CCNA_01099 | | tetracycline resistance protein | low | > 66 |
| Caulobacter crescentus NA1000 Δfur | 0.66 | CCNA_01666 | | osmosensitive K+ channel histidine kinase kdpD | 0.48 | CCNA_01099 | | tetracycline resistance protein | low | > 67 |
| Azospirillum brasilense Sp245 | 0.39 | AZOBR_RS23975 | | histidine kinase | 0.09 | AZOBR_RS13080 | | putative MFS superfamily multidrug transport protein | low | > 97 |
| Agrobacterium fabrum C58 | 0.38 | Atu3787 | | two component sensor kinase | 0.16 | Atu4206 | | tetracycline resistance protein | low | > 89 |
| Azospirillum sp. SherDot2 | 0.38 | MPMX19_03748 | | Sensor protein KdpD | 0.19 | MPMX19_06037 | | Tetracycline resistance protein, class C | low | > 112 |
| Rhizobium sp. OAE497 | 0.38 | ABIE40_RS24610 | | sensor histidine kinase KdpD | 0.19 | ABIE40_RS06610 | | TCR/Tet family MFS transporter | low | > 107 |
| Rhodopseudomonas palustris CGA009 | 0.36 | TX73_015550 | | sensor histidine kinase KdpD | 0.20 | TX73_016005 | | tetracycline resistance MFS efflux pump | low | > 86 |
| Sinorhizobium meliloti 1021 | 0.36 | SMa2327 | | sensor protein | 0.16 | SMc01212 | | transport transmembrane protein | low | > 103 |
| Pseudomonas syringae pv. syringae B728a | 0.30 | Psyr_2050 | | ATP-binding region, ATPase-like:Histidine kinase A, N-terminal:Osmosensitive K+ channel His kinase sensor:UspA | 0.11 | Psyr_1706 | | General substrate transporter:Major facilitator superfamily | low | > 86 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.30 | Psyr_2050 | | ATP-binding region, ATPase-like:Histidine kinase A, N-terminal:Osmosensitive K+ channel His kinase sensor:UspA | 0.11 | Psyr_1706 | | General substrate transporter:Major facilitator superfamily | low | > 86 |
| Sphingomonas koreensis DSMZ 15582 | 0.30 | Ga0059261_3881 | | Osmosensitive K+ channel histidine kinase | 0.18 | Ga0059261_0862 | | Arabinose efflux permease | low | > 68 |
| Klebsiella michiganensis M5al | 0.29 | BWI76_RS08305 | | two-component sensor histidine kinase | 0.08 | BWI76_RS06135 | | MFS transporter | low | > 92 |
| Xanthomonas campestris pv. campestris strain 8004 | 0.29 | Xcc-8004.4379.1 | | Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-) | 0.17 | Xcc-8004.5290.1 | | Tetracycline-efflux transporter | low | > 74 |
| Paraburkholderia sabiae LMG 24235 | 0.28 | QEN71_RS24345 | | DUF4118 domain-containing protein | 0.10 | QEN71_RS32345 | | MFS transporter | low | > 153 |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.28 | GFF4607 | | Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-) | 0.12 | GFF2532 | | 12-TMS multidrug efflux protein homolog | low | > 78 |
| Serratia liquefaciens MT49 | 0.28 | IAI46_06165 | | two-component system sensor histidine kinase KdbD | 0.10 | IAI46_12000 | | multidrug efflux MFS transporter | low | > 86 |
| Enterobacter asburiae PDN3 | 0.28 | EX28DRAFT_2283 | | Osmosensitive K+ channel histidine kinase | 0.08 | EX28DRAFT_2590 | | Arabinose efflux permease | low | > 76 |
| Paraburkholderia bryophila 376MFSha3.1 | 0.27 | H281DRAFT_04532 | | two-component system, OmpR family, sensor histidine kinase KdpD | 0.10 | H281DRAFT_03065 | | MFS transporter, DHA1 family, multidrug resistance protein | low | > 103 |
| Escherichia coli Nissle 1917 | 0.27 | ECOLIN_RS03755 | | two-component system sensor histidine kinase KdpD | 0.07 | ECOLIN_RS06115 | | multidrug efflux MFS transporter MdtG | — | — |
| Paraburkholderia graminis OAS925 | 0.27 | ABIE53_001556 | | two-component system sensor histidine kinase KdpD | 0.09 | ABIE53_000733 | | MFS family permease | low | > 113 |
| Enterobacter sp. TBS_079 | 0.27 | MPMX20_01338 | | Sensor protein KdpD | 0.08 | MPMX20_00971 | | Staphyloferrin B transporter | low | > 85 |
| Escherichia coli ECOR27 | 0.27 | NOLOHH_23455 | kdpD | two-component system sensor histidine kinase KdpD | 0.07 | NOLOHH_21305 | mdtG | multidrug efflux MFS transporter MdtG | low | > 75 |
| Escherichia coli ECOR38 | 0.27 | HEPCGN_01160 | kdpD | two-component system sensor histidine kinase KdpD | 0.17 | HEPCGN_10845 | tet(B | tetracycline efflux MFS transporter Tet(B) | low | > 87 |
| Escherichia fergusonii Becca | 0.27 | EFB2_03401 | | Sensor protein KdpD | 0.07 | EFB2_02921 | | Staphyloferrin B transporter | low | > 86 |
| Burkholderia phytofirmans PsJN | 0.27 | BPHYT_RS06460 | | histidine kinase | 0.12 | BPHYT_RS33385 | | major facilitator superfamily protein | low | > 109 |
| Escherichia coli BW25113 | 0.27 | b0695 | kdpD | fused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein (NCBI) | 0.07 | b1053 | mdtG | predicted drug efflux system (NCBI) | low | > 76 |
| Escherichia coli BL21 | 0.27 | ECD_00652 | | fused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein | 0.07 | ECD_01049 | | putative drug efflux system protein | low | > 61 |
| Escherichia coli ECRC62 | 0.27 | BNILDI_21460 | kdpD | two-component system sensor histidine kinase KdpD | 0.17 | BNILDI_09400 | tet(B | tetracycline efflux MFS transporter Tet(B) | low | > 75 |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.27 | OHPLBJKB_03022 | | Sensor protein KdpD | 0.07 | OHPLBJKB_02612 | | Multidrug resistance protein MdtG | low | > 73 |
| Ralstonia solanacearum GMI1000 | 0.27 | RS_RS16960 | | sensor histidine kinase KdpD | 0.10 | RS_RS19260 | | MFS transporter | low | > 80 |
| Pectobacterium carotovorum WPP14 | 0.27 | HER17_RS15045 | | two-component system sensor histidine kinase KdpD | 0.09 | HER17_RS16995 | | multidrug efflux MFS transporter | low | > 75 |
| Dickeya dianthicola 67-19 | 0.27 | HGI48_RS06415 | | two-component system sensor histidine kinase KdpD | 0.08 | HGI48_RS04590 | | multidrug efflux MFS transporter | low | > 71 |
| Ralstonia solanacearum IBSBF1503 | 0.27 | RALBFv3_RS09130 | | sensor histidine kinase KdpD | 0.10 | RALBFv3_RS03495 | | MFS transporter | low | > 76 |
| Ralstonia solanacearum UW163 | 0.27 | UW163_RS04465 | | sensor histidine kinase KdpD | 0.10 | UW163_RS10175 | | MFS transporter | — | — |
| Dickeya dianthicola ME23 | 0.27 | DZA65_RS06760 | | two-component system sensor histidine kinase KdbD | 0.07 | DZA65_RS05960 | | MFS transporter | low | > 75 |
| Rahnella sp. WP5 | 0.26 | EX31_RS23335 | | two-component system sensor histidine kinase KdbD | 0.09 | EX31_RS23770 | | multidrug efflux MFS transporter | low | > 89 |
| Dickeya dadantii 3937 | 0.26 | DDA3937_RS06370 | | two-component system sensor histidine kinase KdpD | 0.08 | DDA3937_RS05575 | | MFS transporter | low | > 74 |
| Erwinia tracheiphila SCR3 | 0.26 | LU632_RS00800 | kdpD | two-component system sensor histidine kinase KdpD | 0.08 | LU632_RS18400 | | MFS transporter | low | > 74 |
| Ralstonia sp. UNC404CL21Col | 0.26 | ABZR87_RS04525 | | sensor histidine kinase KdpD | 0.18 | ABZR87_RS00595 | | Tet(A)/Tet(B)/Tet(C) family tetracycline efflux MFS transporter | low | > 80 |
| Pantoea sp. MT58 | 0.25 | IAI47_01250 | | two-component system sensor histidine kinase KdbD | 0.10 | IAI47_17590 | | MFS transporter | low | > 76 |
| Variovorax sp. SCN45 | 0.25 | GFF3520 | | Osmosensitive K+ channel histidine kinase KdpD | 0.19 | GFF5038 | | Tetracycline resistance, MFS efflux pump => Tet(C) | low | > 127 |
Not shown: 29 genomes with orthologs for A4249_RS15630 only; 16 genomes with orthologs for A4249_RS11115 only