Conservation of cofitness between b2022 and b2025 in Escherichia coli BW25113

45 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b2022 hisB imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) 1.0 b2025 hisF imidazole glycerol phosphate synthase subunit HisF (NCBI) 0.97 7
Escherichia coli ECRC102 1.00 NIAGMN_22450 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 NIAGMN_22435 hisF Imidazole glycerol phosphate synthase subunit HisF — —
Escherichia coli ECOR27 1.00 NOLOHH_15820 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.99 NOLOHH_15805 hisF Imidazole glycerol phosphate synthase subunit HisF low > 57
Escherichia coli ECRC101 1.00 MCAODC_20435 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 MCAODC_20450 hisF Imidazole glycerol phosphate synthase subunit HisF — —
Escherichia coli ECRC101 1.00 OKFHMN_24505 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 OKFHMN_24490 hisF Imidazole glycerol phosphate synthase subunit HisF — —
Escherichia coli ECRC98 1.00 JDDGAC_28615 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 JDDGAC_28600 hisF Imidazole glycerol phosphate synthase subunit HisF — —
Escherichia coli ECRC99 1.00 KEDOAH_03645 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 KEDOAH_03660 hisF Imidazole glycerol phosphate synthase subunit HisF — —
Escherichia coli HS(pFamp)R (ATCC 700891) 0.99 OHPLBJKB_01678 Histidine biosynthesis bifunctional protein HisB 0.99 OHPLBJKB_01675 Imidazole glycerol phosphate synthase subunit HisF low > 73
Escherichia coli BL21 0.99 ECD_01924 histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase 0.99 ECD_01927 imidazole glycerol phosphate synthase, catalytic subunit with HisH — —
Escherichia coli ECOR38 0.99 HEPCGN_03210 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.99 HEPCGN_03195 hisF Imidazole glycerol phosphate synthase subunit HisF low > 85
Escherichia coli ECRC62 0.99 BNILDI_14730 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 BNILDI_14715 hisF Imidazole glycerol phosphate synthase subunit HisF — —
Escherichia fergusonii Becca 0.99 EFB2_01834 Histidine biosynthesis bifunctional protein HisB 1.00 EFB2_01831 Imidazole glycerol phosphate synthase subunit HisF low > 86
Escherichia coli Nissle 1917 0.99 ECOLIN_RS11955 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 1.00 ECOLIN_RS11970 imidazole glycerol phosphate synthase subunit HisF — —
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.96 GFF3910 Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) 0.95 GFF3907 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) low > 78
Enterobacter sp. TBS_079 0.92 MPMX20_03004 Histidine biosynthesis bifunctional protein HisB 0.97 MPMX20_03007 Imidazole glycerol phosphate synthase subunit HisF 0.97 5
Enterobacter asburiae PDN3 0.91 EX28DRAFT_0537 imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) 0.96 EX28DRAFT_0534 imidazoleglycerol phosphate synthase, cyclase subunit 0.92 10
Klebsiella michiganensis M5al 0.88 BWI76_RS18935 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase 0.96 BWI76_RS18950 imidazole glycerol phosphate synthase cyclase subunit 0.91 10
Dickeya dadantii 3937 0.84 DDA3937_RS09725 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.93 DDA3937_RS09710 imidazole glycerol phosphate synthase subunit HisF 0.96 4
Dickeya dianthicola ME23 0.84 DZA65_RS10045 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.92 DZA65_RS10030 imidazole glycerol phosphate synthase subunit HisF 0.84 13
Dickeya dianthicola 67-19 0.84 HGI48_RS09735 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.92 HGI48_RS09720 imidazole glycerol phosphate synthase subunit HisF — —
Serratia liquefaciens MT49 0.84 IAI46_08200 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.95 IAI46_08185 imidazole glycerol phosphate synthase subunit HisF 0.86 7
Pectobacterium carotovorum WPP14 0.83 HER17_RS12240 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.91 HER17_RS12255 imidazole glycerol phosphate synthase subunit HisF 0.98 4
Rahnella sp. WP5 0.83 EX31_RS11450 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.91 EX31_RS11465 imidazole glycerol phosphate synthase subunit HisF 0.95 28
Erwinia tracheiphila SCR3 0.83 LU632_RS08935 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.93 LU632_RS08920 hisF imidazole glycerol phosphate synthase subunit HisF 0.96 2
Pantoea sp. MT58 0.82 IAI47_07080 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.90 IAI47_07065 imidazole glycerol phosphate synthase subunit HisF 0.98 2
Vibrio cholerae E7946 ATCC 55056 0.68 CSW01_05760 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase 0.87 CSW01_05775 imidazole glycerol phosphate synthase cyclase subunit low > 62
Shewanella loihica PV-4 0.66 Shew_2200 imidazole glycerol-phosphate dehydratase/histidinol phosphatase (RefSeq) 0.75 Shew_2203 imidazole glycerol phosphate synthase subunit HisF (RefSeq) 0.98 22
Alteromonas macleodii MIT1002 0.65 MIT1002_02635 Histidine biosynthesis bifunctional protein HisB 0.76 MIT1002_02638 Imidazole glycerol phosphate synthase subunit HisF 0.96 34
Shewanella amazonensis SB2B 0.64 Sama_1944 imidazole glycerol-phosphate dehydratase/histidinol phosphatase (RefSeq) 0.77 Sama_1947 imidazole glycerol phosphate synthase subunit HisF (RefSeq) 0.98 4
Shewanella oneidensis MR-1 0.63 SO2071 hisB imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase (NCBI ptt file) 0.75 SO2068 hisF hisF protein (cyclase) (NCBI ptt file) 0.98 8
Shewanella sp. ANA-3 0.63 Shewana3_1851 imidazole glycerol-phosphate dehydratase/histidinol phosphatase (RefSeq) 0.75 Shewana3_1848 imidazole glycerol phosphate synthase subunit HisF (RefSeq) 0.95 24
Lysobacter sp. OAE881 0.54 ABIE51_RS13315 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.65 ABIE51_RS13300 imidazole glycerol phosphate synthase subunit HisF 0.91 1
Dyella japonica UNC79MFTsu3.2 0.54 ABZR86_RS06720 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.63 ABZR86_RS06705 imidazole glycerol phosphate synthase subunit HisF 0.88 60
Rhodanobacter denitrificans MT42 0.53 LRK55_RS01375 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.64 LRK55_RS01360 imidazole glycerol phosphate synthase subunit HisF 0.65 13
Xanthomonas campestris pv. campestris strain 8004 0.53 Xcc-8004.2946.1 Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) 0.63 Xcc-8004.2943.1 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) 0.92 7
Rhodanobacter denitrificans FW104-10B01 0.53 LRK54_RS01595 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.65 LRK54_RS01580 imidazole glycerol phosphate synthase subunit HisF 0.70 5
Rhodanobacter sp. FW510-T8 0.52 OKGIIK_04960 hisB bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.64 OKGIIK_04975 hisF imidazole glycerol phosphate synthase subunit HisF low > 52
Pontibacter actiniarum KMM 6156, DSM 19842 0.47 CA264_05040 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase 0.47 CA264_05110 imidazole glycerol phosphate synthase cyclase subunit 0.43 7
Bacteroides thetaiotaomicron VPI-5482 0.46 BT0203 histidine biosynthesis bifunctional protein hisB (NCBI ptt file) 0.44 BT1378 imidazole glycerol phosphate synthase subunit hisF (NCBI ptt file) 0.87 20
Bacteroides stercoris CC31F 0.46 HMPREF1181_RS04850 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.42 HMPREF1181_RS11070 imidazole glycerol phosphate synthase subunit HisF 0.95 6
Bacteroides ovatus ATCC 8483 0.46 BACOVA_01232 histidinol-phosphatase 0.44 BACOVA_00219 imidazoleglycerol phosphate synthase, cyclase subunit 0.98 5
Parabacteroides merdae CL09T00C40 0.45 HMPREF1078_RS02440 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.43 HMPREF1078_RS13565 imidazole glycerol phosphate synthase subunit HisF 0.97 24
Echinicola vietnamensis KMM 6221, DSM 17526 0.44 Echvi_2457 histidinol-phosphatase 0.41 Echvi_2516 imidazoleglycerol phosphate synthase, cyclase subunit 0.96 3
Phocaeicola vulgatus CL09T03C04 0.44 HMPREF1058_RS15885 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.46 HMPREF1058_RS06175 imidazole glycerol phosphate synthase subunit HisF 0.92 14
Phocaeicola dorei CL03T12C01 0.44 ABI39_RS11845 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.46 ABI39_RS19930 imidazole glycerol phosphate synthase subunit HisF 0.78 38
Mucilaginibacter yixingensis YX-36 DSM 26809 0.43 ABZR88_RS06870 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB 0.43 ABZR88_RS06855 imidazole glycerol phosphate synthase subunit HisF 0.79 8

Not shown: 1 genomes with orthologs for b2022 only; 56 genomes with orthologs for b2025 only