Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF1000 | | Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) | insig. | 100 | 100 |
| Escherichia coli BW25113 | b4348 | hsdS | specificity determinant for hsdM and hsdR (NCBI) | sig. | 51 | 70 |
| Pantoea sp. MT58 | IAI47_16545 | | restriction endonuclease subunit S | cofit | 49 | 72 |
| Shewanella oneidensis MR-1 | SO4264 | hsdS-2 | type I restriction-modification system, S subunit (NCBI ptt file) | insig. | 40 | 74 |
| Shewanella sp. ANA-3 | Shewana3_2960 | | restriction modification system DNA specificity subunit (RefSeq) | cofit | 40 | 69 |
| Pseudomonas sp. RS175 | PFR28_03898 | | hypothetical protein | insig. | 36 | 76 |
o | Pseudomonas fluorescens FW300-N2E3 | AO353_11440 | | hypothetical protein | insig. | 30 | 100 |
o | Klebsiella michiganensis M5al | BWI76_RS03370 | | type I restriction-modification system subunit S | cofit | 32 | 87 |
o | Alteromonas macleodii MIT1002 | MIT1002_03393 | | Type I restriction enzyme EcoKI specificity protein | insig. | 32 | 89 |
| Rhodanobacter sp. FW510-T8 | OKGIIK_14000 | | restriction endonuclease subunit S | insig. | 25 | 89 |
| Bacteroides ovatus ATCC 8483 | BACOVA_04168 | | type I restriction modification DNA specificity domain protein | insig. | 41 | 37 |
| Phocaeicola dorei CL03T12C01 | ABI39_RS21415 | | restriction endonuclease subunit S | insig. | 41 | 35 |
| Rhodanobacter sp000427505 FW510-R12 | LRK53_RS01060 | | restriction endonuclease subunit S | insig. | 26 | 89 |
| Bacteroides stercoris CC31F | HMPREF1181_RS13600 | | restriction endonuclease subunit S | insig. | 36 | 42 |
| Methylophilus sp. DMC18 | GFF1950 | | Type-1 restriction enzyme EcoKI specificity protein | insig. | 33 | 44 |
o | Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.3938.1 | | Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) | insig. | 25 | 90 |
| Rhodanobacter sp000427505 FW510-R12 | LRK53_RS08650 | | restriction endonuclease subunit S | insig. | 28 | 91 |
| Phocaeicola dorei CL03T12C01 | ABI39_RS21405 | | restriction endonuclease subunit S | insig. | 22 | 71 |
| Bacteroides thetaiotaomicron VPI-5482 | BT4523 | | Type I restriction enzyme EcoR124II specificity protein (NCBI ptt file) | insig. | 25 | 48 |
| Escherichia coli ECOR38 | HEPCGN_10725 | | restriction endonuclease subunit S | insig. | 29 | 37 |
| Phocaeicola dorei CL03T12C01 | ABI39_RS21420 | | restriction endonuclease subunit S | insig. | 22 | 79 |
| Bacteroides stercoris CC31F | HMPREF1181_RS13630 | | restriction endonuclease subunit S | insig. | 22 | 78 |
| Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_0381 | | Restriction endonuclease S subunits | insig. | 22 | 60 |
| Escherichia coli ECOR38 | HEPCGN_09460 | | type I restriction endonuclease subunit S | cofit | 25 | 44 |
| Rhodanobacter denitrificans FW104-10B01 | LRK54_RS09050 | | restriction endonuclease subunit S | insig. | 27 | 41 |
| Pseudomonas putida KT2440 | PP_4742 | | Type I restriction-modification system, S subunit | insig. | 28 | 37 |
| Caulobacter crescentus NA1000 | CCNA_00657 | | type I restriction-modification system specificity subunit | insig. | 24 | 70 |
| Caulobacter crescentus NA1000 Δfur | CCNA_00657 | | type I restriction-modification system specificity subunit | cofit | 24 | 70 |
| Acinetobacter radioresistens SK82 | MPMX26_02869 | | hypothetical protein | strong | 25 | 47 |
| Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS20485 | | hypothetical protein | cofit | 24 | 63 |
| Pseudomonas fluorescens GW456-L13 | PfGW456L13_3107 | | Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) | strong | 27 | 47 |
| Synechocystis sp000284455 PCC 6803 | SGL_RS01155 | | restriction endonuclease subunit S | sig. | 23 | 63 |
| Bacteroides thetaiotaomicron VPI-5482 | BT4520 | | Type I restriction enzyme EcoAI specificity protein (NCBI ptt file) | insig. | 22 | 66 |
| Pseudomonas fluorescens GW456-L13 | PfGW456L13_3107 | | Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) | strong | 23 | 76 |
| Phocaeicola vulgatus CL09T03C04 | HMPREF1058_RS00020 | | restriction endonuclease subunit S | no data | 26 | 40 |
| Pantoea sp. MT58 | IAI47_16545 | | restriction endonuclease subunit S | cofit | 25 | 50 |
| Shewanella oneidensis MR-1 | SO0382 | hsdS-1 | type I restriction-modification system, S subunit (NCBI ptt file) | insig. | 21 | 62 |
| Shewanella oneidensis MR-1 | SO4264 | hsdS-2 | type I restriction-modification system, S subunit (NCBI ptt file) | insig. | 25 | 49 |
| Escherichia coli ECRC100 | OKFHMN_05700 | | restriction endonuclease | insig. | 23 | 41 |
| Bacteroides thetaiotaomicron VPI-5482 | BT4523 | | Type I restriction enzyme EcoR124II specificity protein (NCBI ptt file) | insig. | 19 | 70 |
| Shewanella sp. ANA-3 | Shewana3_2960 | | restriction modification system DNA specificity subunit (RefSeq) | cofit | 26 | 47 |
| Acinetobacter radioresistens SK82 | MPMX26_02869 | | hypothetical protein | strong | 21 | 74 |
| Rhodanobacter denitrificans MT42 | LRK55_RS00335 | | restriction endonuclease subunit S | cofit | 24 | 56 |
| Pseudomonas putida KT2440 | PP_4742 | | Type I restriction-modification system, S subunit | insig. | 25 | 28 |
| Bacteroides thetaiotaomicron VPI-5482 | BT4520 | | Type I restriction enzyme EcoAI specificity protein (NCBI ptt file) | insig. | 25 | 41 |
| Methylophilus sp. DMC18 | GFF1950 | | Type-1 restriction enzyme EcoKI specificity protein | insig. | 26 | 54 |
| Synechocystis sp000284455 PCC 6803 | SGL_RS01815 | | restriction endonuclease subunit S | cofit | 24 | 49 |
| Alteromonas macleodii MIT1002 | MIT1002_04091 | | EcoKI restriction-modification system protein HsdS | insig. | 25 | 43 |
| Rhodanobacter denitrificans MT42 | LRK55_RS10120 | | restriction endonuclease subunit S | insig. | 24 | 40 |
| Xanthobacter sp. DMC5 | GFF2199 | | hypothetical protein | insig. | 26 | 30 |
| Phaeobacter inhibens DSM 17395 | PGA1_c30700 | | putative type I restriction-modification system, S subunit | insig. | 27 | 54 |
| Shewanella sp. ANA-3 | Shewana3_3793 | | restriction modification system DNA specificity subunit (RefSeq) | insig. | 22 | 44 |
| Fusobacterium nucleatum SB010 | HUW76_09000 | | restriction endonuclease subunit S | cofit | 32 | 31 |
| Escherichia coli BW25113 | b4348 | hsdS | specificity determinant for hsdM and hsdR (NCBI) | sig. | 21 | 47 |
| Marinobacter adhaerens HP15 | HP15_1579 | | type I site-specific restriction-modification system, S subunit | sig. | 25 | 56 |
| Pseudomonas stutzeri RCH2 | Psest_3406 | | Restriction endonuclease S subunits | sig. | 23 | 74 |
| Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_0381 | | Restriction endonuclease S subunits | insig. | 31 | 23 |
| Echinicola vietnamensis KMM 6221, DSM 17526 | Echvi_4441 | | Restriction endonuclease S subunits | insig. | 26 | 31 |
| Shewanella sp. ANA-3 | Shewana3_3793 | | restriction modification system DNA specificity subunit (RefSeq) | insig. | 21 | 69 |
| Cellulophaga baltica 18 | M666_RS14695 | | restriction endonuclease subunit S | insig. | 25 | 24 |
| Pedobacter sp. GW460-11-11-14-LB5 | CA265_RS20485 | | hypothetical protein | cofit | 23 | 44 |
| Escherichia coli ECOR38 | HEPCGN_09460 | | type I restriction endonuclease subunit S | cofit | 25 | 36 |
| Xanthomonas campestris pv. campestris strain 8004 | Xcc-8004.1524.1 | | Type I restriction-modification system, specificity subunit S (EC 3.1.21.3) | insig. | 20 | 69 |
| Rhodanobacter sp. FW510-T8 | OKGIIK_13430 | | Methylase-S domain-containing protein | insig. | 23 | 43 |
| Desulfovibrio vulgaris Hildenborough JW710 | DVU1705 | | type I restriction-modification enzyme, S subunit (TIGR) | insig. | 20 | 44 |