| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Azospirillum sp. SherDot2 | 1.0 | MPMX19_00635 | | 5,10-methylenetetrahydrofolate reductase | 1.0 | MPMX19_00693 | | 5-formyltetrahydrofolate cyclo-ligase | 0.83 | 14 |
| Azospirillum brasilense Sp245 | 0.90 | AZOBR_RS09540 | | 5 10-methylenetetrahydrofolate reductase | 0.56 | AZOBR_RS09025 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 97 |
| Bosea sp. OAE506 | 0.63 | ABIE41_RS12475 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.36 | ABIE41_RS09445 | | 5-formyltetrahydrofolate cyclo-ligase | 0.34 | 64 |
| Sphingomonas koreensis DSMZ 15582 | 0.59 | Ga0059261_0992 | | 5,10-methylenetetrahydrofolate reductase, prokaryotic form | 0.22 | Ga0059261_0735 | | 5,10-methenyltetrahydrofolate synthetase | low | > 68 |
| Caulobacter crescentus NA1000 | 0.57 | CCNA_02224 | | methylenetetrahydrofolate reductase | 0.27 | CCNA_03354 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 66 |
| Caulobacter crescentus NA1000 Δfur | 0.57 | CCNA_02224 | | methylenetetrahydrofolate reductase | 0.27 | CCNA_03354 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 67 |
| Escherichia coli ECRC99 | 0.55 | KEDOAH_14495 | metF | methylenetetrahydrofolate reductase | 0.19 | KEDOAH_08655 | ygfA | 5-formyltetrahydrofolate cyclo-ligase | — | — |
| Escherichia coli ECRC100 | 0.55 | OKFHMN_13665 | metF | methylenetetrahydrofolate reductase | 0.19 | OKFHMN_19485 | ygfA | 5-formyltetrahydrofolate cyclo-ligase | low | > 79 |
| Escherichia coli ECRC98 | 0.55 | JDDGAC_17290 | metF | methylenetetrahydrofolate reductase | 0.19 | JDDGAC_23125 | ygfA | 5-formyltetrahydrofolate cyclo-ligase | low | > 87 |
| Escherichia coli ECRC102 | 0.55 | NIAGMN_11420 | metF | methylenetetrahydrofolate reductase | 0.19 | NIAGMN_17250 | ygfA | 5-formyltetrahydrofolate cyclo-ligase | low | > 80 |
| Escherichia coli ECRC101 | 0.55 | MCAODC_04165 | metF | methylenetetrahydrofolate reductase | 0.19 | MCAODC_10005 | ygfA | 5-formyltetrahydrofolate cyclo-ligase | low | > 88 |
| Escherichia coli ECRC62 | 0.55 | BNILDI_05725 | metF | methylenetetrahydrofolate reductase | 0.19 | BNILDI_09930 | ygfA | 5-formyltetrahydrofolate cyclo-ligase | low | > 75 |
| Escherichia coli ECOR27 | 0.55 | NOLOHH_05810 | metF | methylenetetrahydrofolate reductase | 0.19 | NOLOHH_11395 | ygfA | 5-formyltetrahydrofolate cyclo-ligase | low | > 76 |
| Brevundimonas sp. GW460-12-10-14-LB2 | 0.54 | A4249_RS07925 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.18 | A4249_RS00800 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 48 |
| Escherichia fergusonii Becca | 0.54 | EFB2_04672 | | 5,10-methylenetetrahydrofolate reductase | 0.19 | EFB2_00991 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 86 |
| Rahnella sp. WP5 | 0.54 | EX31_RS14205 | | methylenetetrahydrofolate reductase | 0.20 | EX31_RS21480 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 89 |
| Pantoea agglomerans CFBP13505 P0401 | 0.54 | PagCFBP13505_RS18450 | | methylenetetrahydrofolate reductase | 0.19 | PagCFBP13505_RS15970 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 74 |
| Vibrio cholerae E7946 ATCC 55056 | 0.53 | CSW01_13560 | | methylenetetrahydrofolate reductase | 0.23 | CSW01_12545 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 62 |
| Serratia liquefaciens MT49 | 0.53 | IAI46_24530 | | methylenetetrahydrofolate reductase | 0.21 | IAI46_20895 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 86 |
| Rhizobium sp. OAE497 | 0.52 | ABIE40_RS11950 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.25 | ABIE40_RS15645 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 107 |
| Sinorhizobium meliloti 1021 | 0.50 | SMc01843 | | 5,10-methylenetetrahydrofolate reductase | 0.25 | SMc03974 | | hypothetical protein | low | > 103 |
| Phaeobacter inhibens DSM 17395 | 0.44 | PGA1_c11700 | | 5,10-methylenetetrahydrofolate reductase MetF | 0.26 | PGA1_c21820 | | 5-formyltetrahydrofolate cycloligase-like protein | low | > 62 |
| Dinoroseobacter shibae DFL-12 | 0.41 | Dshi_2080 | | 5,10-methylenetetrahydrofolate reductase (RefSeq) | 0.23 | Dshi_2769 | | 5-formyltetrahydrofolate cyclo-ligase (RefSeq) | — | — |
| Dyella japonica UNC79MFTsu3.2 | 0.39 | ABZR86_RS11570 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.23 | ABZR86_RS11995 | | 5-formyltetrahydrofolate cyclo-ligase | 0.88 | 69 |
| Cupriavidus basilensis FW507-4G11 | 0.39 | RR42_RS01385 | | 5,10-methylenetetrahydrofolate reductase | 0.24 | RR42_RS01400 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 128 |
| Rhodanobacter sp. FW510-T8 | 0.38 | OKGIIK_11830 | metF | methylenetetrahydrofolate reductase [NAD(P)H] | 0.26 | OKGIIK_12225 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 53 |
| Ralstonia solanacearum PSI07 | 0.38 | RPSI07_RS23495 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.23 | RPSI07_RS23505 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 81 |
| Ralstonia sp. UNC404CL21Col | 0.38 | ABZR87_RS04865 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.25 | ABZR87_RS04880 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 80 |
| Ralstonia solanacearum GMI1000 | 0.38 | RS_RS00460 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.23 | RS_RS00450 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 80 |
| Ralstonia solanacearum IBSBF1503 | 0.38 | RALBFv3_RS09875 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.23 | RALBFv3_RS09865 | | 5-formyltetrahydrofolate cyclo-ligase | 0.59 | 33 |
| Ralstonia solanacearum UW163 | 0.38 | UW163_RS03705 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.23 | UW163_RS03715 | | 5-formyltetrahydrofolate cyclo-ligase | — | — |
| Rhodanobacter denitrificans MT42 | 0.37 | LRK55_RS11765 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.26 | LRK55_RS11395 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 63 |
| Rhodanobacter denitrificans FW104-10B01 | 0.37 | LRK54_RS12030 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.25 | LRK54_RS11670 | | 5-formyltetrahydrofolate cyclo-ligase | 0.69 | 18 |
| Rhodanobacter sp000427505 FW510-R12 | 0.37 | LRK53_RS16505 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.20 | LRK53_RS16890 | | 5-formyltetrahydrofolate cyclo-ligase | low | > 59 |
| Dechlorosoma suillum PS | 0.37 | Dsui_0640 | | 5,10-methylenetetrahydrofolate reductase | 0.19 | Dsui_0682 | | 5,10-methenyltetrahydrofolate synthetase | — | — |
| Castellaniella sp019104865 MT123 | 0.35 | ABCV34_RS13550 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.24 | ABCV34_RS13555 | | 5-formyltetrahydrofolate cyclo-ligase | — | — |
| Variovorax sp. OAS795 | 0.32 | ABID97_RS25015 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.16 | ABID97_RS06600 | | 5-formyltetrahydrofolate cyclo-ligase | 0.63 | 82 |
Not shown: 79 genomes with orthologs for MPMX19_00635 only; 0 genomes with orthologs for MPMX19_00693 only