Conservation of cofitness between b3368 and b2414 in Escherichia coli BW25113

48 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b3368 cysG fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) 1.0 b2414 cysK cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) 0.95 4
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_00334 Siroheme synthase 1.00 OHPLBJKB_01309 Cysteine synthase A low > 73
Escherichia coli BL21 1.00 ECD_03219 fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase 1.00 ECD_02314 cysteine synthase A, O-acetylserine sulfhydrolase A subunit low > 60
Escherichia coli ECRC101 1.00 OKFHMN_17180 cysG siroheme synthase CysG 1.00 OKFHMN_22200 cysK cysteine synthase A — —
Escherichia coli ECRC98 1.00 JDDGAC_20810 cysG siroheme synthase CysG 1.00 JDDGAC_26150 cysK cysteine synthase A — —
Escherichia coli Nissle 1917 1.00 ECOLIN_RS19285 siroheme synthase CysG 1.00 ECOLIN_RS13870 cysteine synthase A low > 52
Escherichia coli ECRC102 1.00 NIAGMN_14950 cysG siroheme synthase CysG 1.00 NIAGMN_19970 cysK cysteine synthase A — —
Escherichia coli ECRC99 1.00 KEDOAH_10960 cysG siroheme synthase CysG 1.00 KEDOAH_06020 cysK cysteine synthase A — —
Escherichia fergusonii Becca 1.00 EFB2_00454 Siroheme synthase 1.00 EFB2_01462 Cysteine synthase A 0.49 24
Escherichia coli ECRC101 1.00 MCAODC_07710 cysG siroheme synthase CysG 1.00 MCAODC_12730 cysK cysteine synthase A — —
Escherichia coli ECRC62 1.00 BNILDI_02540 cysG siroheme synthase CysG 1.00 BNILDI_12745 cysK cysteine synthase A — —
Escherichia coli ECOR38 1.00 HEPCGN_16010 cysG siroheme synthase CysG 1.00 HEPCGN_21380 cysK cysteine synthase A low > 85
Escherichia coli ECOR27 1.00 NOLOHH_08980 cysG siroheme synthase CysG 1.00 NOLOHH_13880 cysK cysteine synthase A low > 57
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.92 GFF3700 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.94 GFF2044 Cysteine synthase (EC 2.5.1.47) low > 78
Enterobacter asburiae PDN3 0.89 EX28DRAFT_4160 uroporphyrin-III C-methyltransferase 0.93 EX28DRAFT_0214 cysteine synthase A 0.59 31
Enterobacter sp. TBS_079 0.89 MPMX20_04271 Siroheme synthase 0.93 MPMX20_03308 Cysteine synthase A low > 85
Klebsiella michiganensis M5al 0.88 BWI76_RS26055 siroheme synthase 0.94 BWI76_RS20640 cysteine synthase A 0.68 67
Pectobacterium carotovorum WPP14 0.72 HER17_RS01835 siroheme synthase CysG 0.84 HER17_RS17170 cysteine synthase A low > 75
Rahnella sp. WP5 0.71 EX31_RS04680 uroporphyrinogen-III C-methyltransferase 0.81 EX31_RS20175 cysteine synthase A low > 89
Serratia liquefaciens MT49 0.71 IAI46_23670 uroporphyrinogen-III C-methyltransferase 0.82 IAI46_18445 cysteine synthase A low > 86
Erwinia tracheiphila SCR3 0.53 LU632_RS06420 cysG siroheme synthase CysG 0.87 LU632_RS06625 cysK cysteine synthase A 0.93 9
Dickeya dianthicola 67-19 0.51 HGI48_RS17000 uroporphyrinogen-III C-methyltransferase 0.85 HGI48_RS04450 cysteine synthase A 0.72 42
Dickeya dadantii 3937 0.51 DDA3937_RS16930 uroporphyrinogen-III C-methyltransferase 0.86 DDA3937_RS04490 cysteine synthase A 0.87 25
Pseudomonas stutzeri RCH2 0.51 Psest_2037 uroporphyrin-III C-methyltransferase 0.64 Psest_1855 cysteine synthase A low > 67
Dickeya dianthicola ME23 0.50 DZA65_RS18075 uroporphyrinogen-III C-methyltransferase 0.85 DZA65_RS04370 cysteine synthase A 0.66 58
Pantoea sp. MT58 0.50 IAI47_04175 uroporphyrinogen-III C-methyltransferase 0.90 IAI47_05440 cysteine synthase A 0.79 46
Pseudomonas syringae pv. syringae B728a ΔmexB 0.49 Psyr_3174 uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase 0.66 Psyr_1583 cysteine synthase low > 86
Pseudomonas sp. RS175 0.49 PFR28_02603 Siroheme synthase 0.68 PFR28_00734 Cysteine synthase A low > 88
Pseudomonas syringae pv. syringae B728a 0.49 Psyr_3174 uroporphyrinogen-III C-methyltransferase / precorrin-2 dehydrogenase 0.66 Psyr_1583 cysteine synthase low > 86
Pseudomonas fluorescens FW300-N1B4 0.49 Pf1N1B4_4065 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.67 Pf1N1B4_3374 Cysteine synthase (EC 2.5.1.47) low > 87
Pseudomonas fluorescens FW300-N2C3 0.49 AO356_22200 sirohydrochlorin ferrochelatase 0.68 AO356_04305 cysteine synthase low > 104
Pseudomonas fluorescens FW300-N2E2 0.49 Pf6N2E2_302 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.68 Pf6N2E2_2700 Cysteine synthase (EC 2.5.1.47) low > 103
Pseudomonas fluorescens GW456-L13 0.49 PfGW456L13_2656 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.67 PfGW456L13_4472 Cysteine synthase (EC 2.5.1.47) low > 87
Pseudomonas fluorescens FW300-N2E3 0.49 AO353_27625 sirohydrochlorin ferrochelatase 0.68 AO353_18020 cysteine synthase — —
Pseudomonas fluorescens SBW25-INTG 0.48 PFLU_RS18505 uroporphyrinogen-III C-methyltransferase 0.66 PFLU_RS07585 cysteine synthase A low > 109
Pseudomonas simiae WCS417 0.48 PS417_16465 sirohydrochlorin ferrochelatase 0.67 PS417_07505 cysteine synthase low > 88
Pseudomonas fluorescens SBW25 0.48 PFLU_RS18505 uroporphyrinogen-III C-methyltransferase 0.66 PFLU_RS07585 cysteine synthase A low > 109
Pseudomonas putida KT2440 0.47 PP_3999 Uroporphyrinogen-III C-methyltransferase/Precorrin-2 dehydrogenase/Sirohydrochlorin ferrochelatase 0.66 PP_4571 cysteine synthase A low > 96
Pseudomonas sp. S08-1 0.45 OH686_00285 Precorrin-2 oxidase or Sirohydrochlorin ferrochelatase activity of CysG / Uroporphyrinogen-III methyltransferase 0.68 OH686_05215 cysteine synthase A low > 80
Alteromonas macleodii MIT1002 0.45 MIT1002_00665 Siroheme synthase 0.71 MIT1002_02237 Cysteine synthase A — —
Agrobacterium fabrum C58 0.33 Atu3899 siroheme synthase 0.44 Atu0312 cysteine synthase low > 89
Sinorhizobium meliloti 1021 0.32 SMc01053 siroheme synthase 0.45 SMc00421 O-acetylserine sulfhydrylase A low > 103
Rhizobium sp. OAE497 0.31 ABIE40_RS09140 siroheme synthase CysG 0.45 ABIE40_RS01415 cysteine synthase A low > 107
Brevundimonas sp. GW460-12-10-14-LB2 0.31 A4249_RS09675 siroheme synthase CysG 0.45 A4249_RS10255 cysteine synthase A low > 48
Rhodopseudomonas palustris CGA009 0.30 TX73_021850 siroheme synthase CysG 0.44 TX73_002885 cysteine synthase A low > 86
Rhodospirillum rubrum S1H 0.27 Rru_A1933 Uroporphyrin-III C-methyltransferase (NCBI) 0.48 Rru_A3794 Cysteine synthase (NCBI) — —
Dinoroseobacter shibae DFL-12 0.27 Dshi_1155 uroporphyrin-III C-methyltransferase (RefSeq) 0.29 Dshi_0891 cysteine synthase A (RefSeq) — —
Bosea sp. OAE506 0.26 ABIE41_RS15910 siroheme synthase CysG 0.43 ABIE41_RS03545 cysteine synthase A — —
Mycobacterium tuberculosis H37Rv 0.20 Rv2847c Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase 0.48 Rv2334 Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A) — —

Not shown: 8 genomes with orthologs for b3368 only; 29 genomes with orthologs for b2414 only