Conservation of cofitness between BWI76_RS19375 and BWI76_RS20390 in Klebsiella michiganensis M5al

45 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 1.0 BWI76_RS20390 erythronate-4-phosphate dehydrogenase 0.27 8
Escherichia coli ECRC98 0.93 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.82 JDDGAC_26620 pdxB 4-phosphoerythronate dehydrogenase PdxB low > 86
Escherichia coli ECRC99 0.93 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.82 KEDOAH_05535 pdxB 4-phosphoerythronate dehydrogenase PdxB — —
Escherichia coli ECRC102 0.93 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.82 NIAGMN_20435 pdxB 4-phosphoerythronate dehydrogenase PdxB — —
Escherichia coli ECRC100 0.93 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.82 OKFHMN_22660 pdxB 4-phosphoerythronate dehydrogenase PdxB 0.88 19
Escherichia coli ECRC101 0.93 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.82 MCAODC_13700 pdxB 4-phosphoerythronate dehydrogenase PdxB 0.73 23
Escherichia coli BW25113 0.93 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.83 b2320 pdxB erythronate-4-phosphate dehydrogenase (NCBI) 0.71 6
Escherichia coli ECOR27 0.93 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.82 NOLOHH_14295 pdxB 4-phosphoerythronate dehydrogenase PdxB low > 75
Escherichia coli HS(pFamp)R (ATCC 700891) 0.93 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.83 OHPLBJKB_01385 Erythronate-4-phosphate dehydrogenase low > 73
Escherichia coli ECRC62 0.93 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.82 BNILDI_13215 pdxB 4-phosphoerythronate dehydrogenase PdxB 0.74 25
Escherichia fergusonii Becca 0.92 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.83 EFB2_01538 Erythronate-4-phosphate dehydrogenase low > 86
Escherichia coli BL21 0.92 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase 0.83 ECD_02245 erythronate-4-phosphate dehydrogenase low > 61
Escherichia coli ECOR38 0.92 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.81 HEPCGN_21865 pdxB 4-phosphoerythronate dehydrogenase PdxB 0.88 4
Escherichia coli Nissle 1917 0.91 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 ECOLIN_RS13445 4-phosphoerythronate dehydrogenase PdxB — —
Enterobacter sp. TBS_079 0.90 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.83 MPMX20_03255 Erythronate-4-phosphate dehydrogenase 0.59 2
Enterobacter asburiae PDN3 0.90 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.84 EX28DRAFT_0284 Phosphoglycerate dehydrogenase and related dehydrogenases 0.59 16
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.90 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.86 GFF1936 Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290) low > 78
Pectobacterium carotovorum WPP14 0.79 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.70 HER17_RS06980 4-phosphoerythronate dehydrogenase PdxB low > 75
Serratia liquefaciens MT49 0.77 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.72 IAI46_17850 4-phosphoerythronate dehydrogenase PdxB low > 86
Rahnella sp. WP5 0.77 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.72 EX31_RS19610 4-phosphoerythronate dehydrogenase PdxB low > 89
Dickeya dianthicola 67-19 0.76 HGI48_RS15410 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.70 HGI48_RS14445 4-phosphoerythronate dehydrogenase PdxB low > 71
Dickeya dadantii 3937 0.76 DDA3937_RS15335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.75 DDA3937_RS14475 4-phosphoerythronate dehydrogenase PdxB low > 74
Dickeya dianthicola ME23 0.76 DZA65_RS16235 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.74 DZA65_RS15380 4-phosphoerythronate dehydrogenase PdxB low > 75
Erwinia tracheiphila SCR3 0.75 LU632_RS08590 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.73 LU632_RS07815 DUF3410 domain-containing protein — —
Pantoea sp. MT58 0.75 IAI47_06810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.73 IAI47_06235 4-phosphoerythronate dehydrogenase PdxB low > 76
Parabacteroides merdae CL09T00C40 0.43 HMPREF1078_RS03470 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.33 HMPREF1078_RS19150 4-phosphoerythronate dehydrogenase PdxB low > 61
Vibrio cholerae E7946 ATCC 55056 0.40 CSW01_06545 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.48 CSW01_10525 DUF3410 domain-containing protein — —
Phocaeicola vulgatus CL09T03C04 0.39 HMPREF1058_RS06820 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.34 HMPREF1058_RS10820 4-phosphoerythronate dehydrogenase PdxB 0.88 5
Phocaeicola dorei CL03T12C01 0.39 ABI39_RS20615 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.34 ABI39_RS06250 4-phosphoerythronate dehydrogenase PdxB 0.77 9
Bacteroides stercoris CC31F 0.38 HMPREF1181_RS14705 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.34 HMPREF1181_RS02440 4-phosphoerythronate dehydrogenase PdxB — —
Bacteroides thetaiotaomicron VPI-5482 0.36 BT0790 phosphomethylpyrimidine kinase (NCBI ptt file) 0.32 BT3361 erythronate-4-phosphate dehydrogenase (NCBI ptt file) 0.37 64
Bacteroides ovatus ATCC 8483 0.35 BACOVA_02530 phosphomethylpyrimidine kinase 0.33 BACOVA_01953 4-phosphoerythronate dehydrogenase 0.60 83
Pseudomonas fluorescens SBW25-INTG 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.40 PFLU_RS07615 4-phosphoerythronate dehydrogenase PdxB — —
Pseudomonas fluorescens SBW25 0.24 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.40 PFLU_RS07615 4-phosphoerythronate dehydrogenase PdxB — —
Pseudomonas simiae WCS417 0.23 PS417_24600 hydrogenase 0.41 PS417_07535 erythronate-4-phosphate dehydrogenase — —
Pseudomonas putida KT2440 0.22 PP_4782 Phosphomethylpyrimidine kinase 0.38 PP_2117 Erythronate-4-phosphate dehydrogenase — —
Pseudomonas fluorescens GW456-L13 0.22 PfGW456L13_1385 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.42 PfGW456L13_4048 Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290) — —
Pseudomonas fluorescens FW300-N2E3 0.22 AO353_06350 hydrogenase 0.42 AO353_00545 erythronate-4-phosphate dehydrogenase — —
Pseudomonas fluorescens FW300-N2C3 0.22 AO356_15435 hydrogenase 0.40 AO356_02365 erythronate-4-phosphate dehydrogenase — —
Pseudomonas stutzeri RCH2 0.21 Psest_0537 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.37 Psest_2548 Phosphoglycerate dehydrogenase and related dehydrogenases — —
Pseudomonas syringae pv. syringae B728a ΔmexB 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.43 Psyr_1828 4-phosphoerythronate dehydrogenase — —
Pseudomonas syringae pv. syringae B728a 0.21 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.43 Psyr_1828 4-phosphoerythronate dehydrogenase — —
Acinetobacter radioresistens SK82 0.21 MPMX26_02438 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.31 MPMX26_02238 Erythronate-4-phosphate dehydrogenase — —
Pseudomonas sp. RS175 0.20 PFR28_03843 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.39 PFR28_01103 Erythronate-4-phosphate dehydrogenase — —
Pseudomonas fluorescens FW300-N1B4 0.18 Pf1N1B4_2718 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.41 Pf1N1B4_3893 Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290) — —
Pseudomonas fluorescens FW300-N2E2 0.18 Pf6N2E2_5024 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.40 Pf6N2E2_2297 Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290) — —

Not shown: 43 genomes with orthologs for BWI76_RS19375 only; 8 genomes with orthologs for BWI76_RS20390 only