Conservation of cofitness between BWI76_RS16510 and BWI76_RS04875 in Klebsiella michiganensis M5al

40 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS16510 transcriptional repressor PurR 1.0 BWI76_RS04875 transcriptional regulator PdhR 0.21 12
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.94 GFF3618 Purine nucleotide synthesis repressor 0.86 GFF123 Transcriptional repressor for pyruvate dehydrogenase complex low > 78
Enterobacter asburiae PDN3 0.94 EX28DRAFT_1655 Transcriptional regulators 0.90 EX28DRAFT_3708 Transcriptional regulators 0.55 4
Enterobacter sp. TBS_079 0.94 MPMX20_01978 HTH-type transcriptional repressor PurR 0.91 MPMX20_00806 Pyruvate dehydrogenase complex repressor low > 85
Escherichia fergusonii Becca 0.94 EFB2_02334 HTH-type transcriptional repressor PurR 0.86 EFB2_03932 Pyruvate dehydrogenase complex repressor low > 86
Escherichia coli ECRC98 0.93 JDDGAC_01975 purR HTH-type transcriptional repressor PurR 0.86 JDDGAC_14105 pdhR pyruvate dehydrogenase complex transcriptional repressor PdhR low > 86
Escherichia coli ECOR27 0.93 NOLOHH_17905 purR HTH-type transcriptional repressor PurR 0.86 NOLOHH_02855 pdhR pyruvate dehydrogenase complex transcriptional repressor PdhR low > 75
Escherichia coli ECRC101 0.93 MCAODC_18025 purR HTH-type transcriptional repressor PurR 0.86 MCAODC_01025 pdhR pyruvate dehydrogenase complex transcriptional repressor PdhR low > 87
Escherichia coli BW25113 0.93 b1658 purR DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) 0.86 b0113 pdhR transcriptional regulator of pyruvate dehydrogenase complex (NCBI) low > 76
Escherichia coli ECRC100 0.93 OKFHMN_27385 purR HTH-type transcriptional repressor PurR 0.86 OKFHMN_10510 pdhR pyruvate dehydrogenase complex transcriptional repressor PdhR low > 80
Escherichia coli ECRC102 0.93 NIAGMN_00680 purR HTH-type transcriptional repressor PurR 0.86 NIAGMN_08360 pdhR pyruvate dehydrogenase complex transcriptional repressor PdhR — —
Escherichia coli ECOR38 0.93 HEPCGN_05770 purR HTH-type transcriptional repressor PurR 0.86 HEPCGN_08490 pdhR pyruvate dehydrogenase complex transcriptional repressor PdhR low > 87
Escherichia coli ECRC62 0.93 BNILDI_16695 purR HTH-type transcriptional repressor PurR 0.86 BNILDI_08755 pdhR pyruvate dehydrogenase complex transcriptional repressor PdhR 0.52 54
Escherichia coli HS(pFamp)R (ATCC 700891) 0.93 OHPLBJKB_02066 HTH-type transcriptional repressor PurR 0.86 OHPLBJKB_03548 Pyruvate dehydrogenase complex repressor low > 73
Escherichia coli Nissle 1917 0.93 ECOLIN_RS09245 HTH-type transcriptional repressor PurR 0.86 ECOLIN_RS00635 pyruvate dehydrogenase complex transcriptional repressor PdhR — —
Escherichia coli ECRC99 0.93 KEDOAH_00725 purR HTH-type transcriptional repressor PurR 0.86 KEDOAH_17645 pdhR pyruvate dehydrogenase complex transcriptional repressor PdhR — —
Escherichia coli BL21 0.93 ECD_01629 transcriptional repressor, hypoxanthine-binding 0.86 ECD_00112 pyruvate dehydrogenase complex repressor; autorepressor low > 61
Pantoea sp. MT58 0.85 IAI47_10795 HTH-type transcriptional repressor PurR 0.77 IAI47_15815 pyruvate dehydrogenase complex transcriptional repressor PdhR low > 76
Serratia liquefaciens MT49 0.84 IAI46_11240 HTH-type transcriptional repressor PurR 0.86 IAI46_21330 pyruvate dehydrogenase complex transcriptional repressor PdhR low > 86
Dickeya dianthicola ME23 0.82 DZA65_RS13140 HTH-type transcriptional repressor PurR 0.79 DZA65_RS19005 pyruvate dehydrogenase complex transcriptional repressor PdhR low > 75
Dickeya dianthicola 67-19 0.82 HGI48_RS12685 HTH-type transcriptional repressor PurR 0.79 HGI48_RS17855 pyruvate dehydrogenase complex transcriptional repressor PdhR low > 71
Erwinia tracheiphila SCR3 0.82 LU632_RS11190 purR HTH-type transcriptional repressor PurR 0.74 LU632_RS03075 pdhR pyruvate dehydrogenase complex transcriptional repressor PdhR low > 74
Dickeya dadantii 3937 0.82 DDA3937_RS12620 HTH-type transcriptional repressor PurR 0.79 DDA3937_RS17930 pyruvate dehydrogenase complex transcriptional repressor PdhR low > 74
Rahnella sp. WP5 0.82 EX31_RS13830 HTH-type transcriptional repressor PurR 0.85 EX31_RS03485 pyruvate dehydrogenase complex transcriptional repressor PdhR low > 89
Pectobacterium carotovorum WPP14 0.81 HER17_RS09235 HTH-type transcriptional repressor PurR 0.78 HER17_RS03285 pyruvate dehydrogenase complex transcriptional repressor PdhR low > 75
Vibrio cholerae E7946 ATCC 55056 0.51 CSW01_08660 PurR family transcriptional regulator 0.66 CSW01_12225 pyruvate dehydrogenase complex transcriptional repressor PdhR low > 62
Pseudomonas fluorescens FW300-N2E3 0.39 AO353_20830 LacI family transcriptional regulator 0.42 AO353_05695 transcriptional regulator PdhR low > 101
Pseudomonas fluorescens FW300-N2E2 0.38 Pf6N2E2_164 Ribose operon repressor 0.41 Pf6N2E2_3379 Lactate-responsive regulator LldR in Enterobacteria, GntR family low > 103
Pseudomonas fluorescens FW300-N2C3 0.38 AO356_00955 LacI family transcriptional regulator 0.41 AO356_07545 transcriptional regulator PdhR low > 104
Pseudomonas putida KT2440 0.37 PP_2457 DNA-binding transcriptional repressor 0.39 PP_4734 DNA-binding transcriptional dual regulator, LldR-L-lactate low > 96
Pseudomonas fluorescens FW300-N1B4 0.37 Pf1N1B4_6032 Ribose operon repressor 0.42 Pf1N1B4_1185 Lactate-responsive regulator LldR in Enterobacteria, GntR family low > 87
Pseudomonas fluorescens SBW25 0.37 PFLU_RS20365 LacI family DNA-binding transcriptional regulator 0.42 PFLU_RS25940 FCD domain-containing protein low > 109
Pseudomonas fluorescens SBW25-INTG 0.37 PFLU_RS20365 LacI family DNA-binding transcriptional regulator 0.42 PFLU_RS25940 FCD domain-containing protein low > 109
Paraburkholderia sabiae LMG 24235 0.37 QEN71_RS07355 LacI family DNA-binding transcriptional regulator 0.29 QEN71_RS10135 FadR/GntR family transcriptional regulator low > 153
Pseudomonas simiae WCS417 0.36 PS417_18390 LacI family transcriptional regulator 0.38 PS417_24100 transcriptional regulator PdhR low > 88
Pseudomonas sp. RS175 0.36 PFR28_02734 Ribose operon repressor 0.41 PFR28_00064 Pyruvate dehydrogenase complex repressor low > 88
Burkholderia phytofirmans PsJN 0.36 BPHYT_RS11205 LacI family transcription regulator 0.28 BPHYT_RS26990 GntR family transcriptional regulator low > 109
Paraburkholderia bryophila 376MFSha3.1 0.35 H281DRAFT_05228 transcriptional regulator, LacI family 0.29 H281DRAFT_02906 transcriptional regulator, GntR family low > 103
Paraburkholderia graminis OAS925 0.35 ABIE53_002322 LacI family transcriptional regulator 0.29 ABIE53_005884 GntR family transcriptional repressor for pyruvate dehydrogenase complex low > 113
Cupriavidus basilensis FW507-4G11 0.22 RR42_RS29910 LacI family transcriptional regulator 0.27 RR42_RS21300 GntR family transcriptional regulator low > 128
Mycobacterium tuberculosis H37Rv 0.14 Rv3575c Transcriptional regulatory protein (probably LacI-family) 0.13 Rv0494 Probable transcriptional regulatory protein (probably GntR-family) low > 58

Not shown: 11 genomes with orthologs for BWI76_RS16510 only; 18 genomes with orthologs for BWI76_RS04875 only