Conservation of cofitness between b1992 and b1622 in Escherichia coli BW25113

36 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b1992 cobS cobalamin synthase (NCBI) 1.0 b1622 malY bifunctional beta-cystathionase, PLP-dependent/ regulator of maltose regulon (NCBI) 0.18 9
Escherichia coli ECRC62 0.99 BNILDI_14870 cobS adenosylcobinamide-GDP ribazoletransferase 0.99 BNILDI_16890 malY bifunctional maltose regulon transcriptional repressor/cystathionine beta-lyase MalY — —
Escherichia coli ECRC101 0.99 OKFHMN_25130 cobS adenosylcobinamide-GDP ribazoletransferase 1.00 OKFHMN_27585 malY bifunctional maltose regulon transcriptional repressor/cystathionine beta-lyase MalY — —
Escherichia coli ECRC101 0.99 MCAODC_20260 cobS adenosylcobinamide-GDP ribazoletransferase 1.00 MCAODC_17825 malY bifunctional maltose regulon transcriptional repressor/cystathionine beta-lyase MalY — —
Escherichia coli ECRC98 0.99 JDDGAC_29260 cobS adenosylcobinamide-GDP ribazoletransferase 1.00 JDDGAC_02175 malY bifunctional maltose regulon transcriptional repressor/cystathionine beta-lyase MalY — —
Escherichia coli ECRC99 0.99 KEDOAH_02980 cobS adenosylcobinamide-GDP ribazoletransferase 1.00 KEDOAH_00520 malY bifunctional maltose regulon transcriptional repressor/cystathionine beta-lyase MalY — —
Escherichia coli BL21 0.99 ECD_01901 cobalamin synthase 0.99 ECD_01591 PLP-dependent beta-cystathionase and maltose regulon regulator low > 60
Escherichia coli HS(pFamp)R (ATCC 700891) 0.99 OHPLBJKB_01716 Adenosylcobinamide-GDP ribazoletransferase 1.00 OHPLBJKB_02104 Protein MalY low > 73
Escherichia coli ECOR27 0.99 NOLOHH_16040 cobS adenosylcobinamide-GDP ribazoletransferase 0.99 NOLOHH_18100 malY bifunctional maltose regulon transcriptional repressor/cystathionine beta-lyase MalY — —
Escherichia coli Nissle 1917 0.98 ECOLIN_RS11625 adenosylcobinamide-GDP ribazoletransferase 0.99 ECOLIN_RS09050 bifunctional maltose regulon transcriptional repressor/cystathionine beta-lyase MalY low > 52
Escherichia fergusonii Becca 0.98 EFB2_01897 Adenosylcobinamide-GDP ribazoletransferase 0.99 EFB2_02370 Protein MalY low > 86
Escherichia coli ECOR38 0.98 HEPCGN_03465 cobS adenosylcobinamide-GDP ribazoletransferase 0.99 HEPCGN_05965 malY bifunctional maltose regulon transcriptional repressor/cystathionine beta-lyase MalY low > 85
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.82 GFF3968 Cobalamin synthase (EC 2.7.8.26) 0.26 GFF2547 Aspartate aminotransferase (EC 2.6.1.1) low > 78
Klebsiella michiganensis M5al 0.66 BWI76_RS18750 adenosylcobinamide-GDP ribazoletransferase 0.75 BWI76_RS16300 bifunctional beta-cystathionase/maltose regulon regulatory protein — —
Rahnella sp. WP5 0.43 EX31_RS09930 adenosylcobinamide-GDP ribazoletransferase 0.72 EX31_RS06865 pyridoxal phosphate-dependent aminotransferase low > 89
Fusobacterium nucleatum SB010 0.26 HUW76_05620 adenosylcobinamide-GDP ribazoletransferase 0.27 HUW76_06165 pyridoxal phosphate-dependent aminotransferase low > 35
Phaeobacter inhibens DSM 17395 0.21 PGA1_c07560 putative cobalamin-5-phosphate synthase 0.23 PGA1_c00860 cystathionine beta-lyase PatB — —
Pseudomonas sp. RS175 0.20 PFR28_03200 Adenosylcobinamide-GDP ribazoletransferase 0.26 PFR28_02099 Cystathionine beta-lyase PatB low > 88
Dechlorosoma suillum PS 0.20 Dsui_0471 cobalamin 5''-phosphate synthase/cobalamin synthase 0.25 Dsui_3257 bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities low > 51
Parabacteroides merdae CL09T00C40 0.19 HMPREF1078_RS17675 adenosylcobinamide-GDP ribazoletransferase 0.29 HMPREF1078_RS16700 PatB family C-S lyase low > 61
Ralstonia solanacearum IBSBF1503 0.19 RALBFv3_RS04475 adenosylcobinamide-GDP ribazoletransferase 0.22 RALBFv3_RS16055 putative C-S lyase low > 76
Phocaeicola vulgatus CL09T03C04 0.18 HMPREF1058_RS01280 adenosylcobinamide-GDP ribazoletransferase 0.29 HMPREF1058_RS07560 pyridoxal phosphate-dependent aminotransferase low > 67
Pseudomonas fluorescens GW456-L13 0.17 PfGW456L13_4234 Cobalamin synthase 0.26 PfGW456L13_3090 putative aminotransferase low > 87
Pseudomonas simiae WCS417 0.17 PS417_20020 cobalamin synthase 0.24 PS417_12965 aminotransferase low > 88
Bacteroides stercoris CC31F 0.16 HMPREF1181_RS15660 adenosylcobinamide-GDP ribazoletransferase 0.27 HMPREF1181_RS06410 pyridoxal phosphate-dependent aminotransferase low > 56
Pseudomonas fluorescens SBW25-INTG 0.16 PFLU_RS21985 adenosylcobinamide-GDP ribazoletransferase 0.24 PFLU_RS13630 putative C-S lyase low > 109
Pseudomonas fluorescens SBW25 0.16 PFLU_RS21985 adenosylcobinamide-GDP ribazoletransferase 0.24 PFLU_RS13630 putative C-S lyase low > 109
Phocaeicola dorei CL03T12C01 0.16 ABI39_RS16450 adenosylcobinamide-GDP ribazoletransferase 0.30 ABI39_RS19290 pyridoxal phosphate-dependent aminotransferase low > 72
Bacteroides ovatus ATCC 8483 0.14 BACOVA_03274 cobalamin-5-phosphate synthase 0.32 BACOVA_04944 aminotransferase, class I/II low > 94
Dinoroseobacter shibae DFL-12 0.14 Dshi_0787 cobalamin-5-phosphate synthase CobS (RefSeq) 0.21 Dshi_0178 aminotransferase class I and II (RefSeq) — —
Pseudomonas fluorescens FW300-N2C3 0.14 AO356_19180 cobalamin synthase 0.25 AO356_26930 aminotransferase low > 104
Bosea sp. OAE506 0.14 ABIE41_RS21250 adenosylcobinamide-GDP ribazoletransferase 0.21 ABIE41_RS12595 PatB family C-S lyase — —
Desulfovibrio vulgaris Miyazaki F 0.13 DvMF_1392 cobalamin-5-phosphate synthase CobS (RefSeq) 0.27 DvMF_1822 aminotransferase class I and II (RefSeq) — —
Mycobacterium tuberculosis H37Rv 0.13 Rv2208 Probable cobalamin 5'-phosphate synthase CobS 0.20 Rv2294 Probable aminotransferase low > 58
Pseudomonas fluorescens FW300-N1B4 0.13 Pf1N1B4_3715 Cobalamin synthase 0.26 Pf1N1B4_4946 putative aminotransferase low > 87
Pseudomonas fluorescens FW300-N2E2 0.12 Pf6N2E2_5746 Cobalamin synthase 0.26 Pf6N2E2_1210 putative aminotransferase low > 103
Desulfovibrio vulgaris Hildenborough JW710 0.12 DVU0914 cobS cobalamin-5-phosphate synthase (TIGR) 0.28 DVU0171 patB hemolysin-related protein (TIGR) low > 55

Not shown: 42 genomes with orthologs for b1992 only; 8 genomes with orthologs for b1622 only