| Orth | Species | Gene | Name | Description | Fitness | %Id | Cov |
| | Magnetospirillum magneticum AMB-1 | AMB_RS09800 | | uptake hydrogenase | insig. | 100 | 100 |
| o | Variovorax sp. OAS795 | ABID97_RS13580 | | nickel-dependent hydrogenase large subunit | insig. | 59 | 99 |
| o | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF2208 | | Uptake hydrogenase large subunit (EC 1.12.99.6) | insig. | 59 | 99 |
| o | Xanthobacter sp. DMC5 | GFF2241 | | Periplasmic [NiFeSe] hydrogenase large subunit | insig. | 58 | 100 |
| o | Dechlorosoma suillum PS | Dsui_1152 | | Ni,Fe-hydrogenase I large subunit | cofit | 57 | 99 |
| o | Azospirillum sp. SherDot2 | MPMX19_05298 | | Periplasmic [NiFeSe] hydrogenase large subunit | insig. | 57 | 89 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS05660 | | Ni,Fe-hydrogenase I large subunit | cofit | 38 | 100 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU1918 | hysA | periplasmic [NiFeSe] hydrogenase, large subunit, selenocysteine-containing (TIGR) | strong | 32 | 99 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_0273 | | nickel-dependent hydrogenase large subunit (RefSeq) | cofit | 31 | 97 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU2526 | hynA-2 | periplasmic [NiFe] hydrogenase, large subunit, isozyme 2 (TIGR) | insig. | 29 | 99 |
| | Desulfovibrio vulgaris Hildenborough JW710 | DVU1922 | hynA-1 | periplasmic [NiFe] hydrogenase, large subunit, isozyme 1 (TIGR) | insig. | 29 | 99 |
| | Azospirillum brasilense Sp245 | AZOBR_RS20390 | | hydrogenase 2 large subunit | insig. | 28 | 99 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_1733 | | nickel-dependent hydrogenase large subunit (RefSeq) | insig. | 29 | 99 |
| | Dechlorosoma suillum PS | Dsui_3009 | | Ni,Fe-hydrogenase I large subunit | insig. | 29 | 99 |
| | Escherichia coli BL21 | ECD_02870 | | hydrogenase 2, large subunit | cofit | 28 | 99 |
| | Escherichia fergusonii Becca | EFB2_00813 | | Hydrogenase-2 large chain | cofit | 28 | 99 |
| | Escherichia coli ECOR27 | NOLOHH_10795 | hybC | hydrogenase 2 large subunit | insig. | 28 | 99 |
| | Escherichia coli ECOR38 | HEPCGN_17880 | hybC | hydrogenase 2 large subunit | insig. | 28 | 99 |
| | Escherichia coli ECRC100 | OKFHMN_19020 | hybC | hydrogenase 2 large subunit | cofit | 28 | 99 |
| | Escherichia coli ECRC101 | MCAODC_09535 | hybC | hydrogenase 2 large subunit | insig. | 28 | 99 |
| | Escherichia coli ECRC102 | NIAGMN_16785 | hybC | hydrogenase 2 large subunit | insig. | 28 | 99 |
| | Escherichia coli ECRC62 | BNILDI_00720 | hybC | hydrogenase 2 large subunit | insig. | 28 | 99 |
| | Escherichia coli ECRC99 | KEDOAH_09125 | hybC | hydrogenase 2 large subunit | no data | 28 | 99 |
| | Escherichia coli HS(pFamp)R (ATCC 700891) | OHPLBJKB_00705 | | Hydrogenase-2 large chain | insig. | 28 | 99 |
| | Escherichia coli Nissle 1917 | ECOLIN_RS17250 | | hydrogenase 2 large subunit | cofit | 28 | 99 |
| | Escherichia coli BW25113 | b2994 | hybC | hydrogenase 2, large subunit (NCBI) | sig. | 28 | 99 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF3105 | | Uptake hydrogenase large subunit (EC 1.12.99.6) | insig. | 26 | 99 |
| | Desulfovibrio vulgaris Miyazaki F | DvMF_0270 | | nickel-dependent hydrogenase large subunit (RefSeq) | insig. | 29 | 99 |
| | Escherichia coli ECRC98 | JDDGAC_22655 | hybC | hydrogenase 2 large subunit | insig. | 28 | 99 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS08335 | | nickel-dependent hydrogenase large subunit | insig. | 29 | 99 |
| | Shewanella oneidensis MR-1 | SO2098 | hyaB | quinone-reactive Ni/Fe hydrogenase, large subunit (NCBI ptt file) | insig. | 28 | 99 |
| | Shewanella amazonensis SB2B | Sama_1678 | | hydrogenase large chain (RefSeq) | insig. | 27 | 99 |
| | Dickeya dadantii 3937 | DDA3937_RS14240 | | hydrogenase 2 large subunit | insig. | 27 | 99 |
| | Shewanella sp. ANA-3 | Shewana3_1879 | | nickel-dependent hydrogenase, large subunit (RefSeq) | insig. | 27 | 99 |
| | Dickeya dianthicola 67-19 | HGI48_RS14215 | | hydrogenase 2 large subunit | insig. | 26 | 99 |
| | Dickeya dianthicola ME23 | DZA65_RS14890 | | hydrogenase 2 large subunit | insig. | 26 | 99 |
| | Shewanella loihica PV-4 | Shew_1764 | | nickel-dependent hydrogenase, large subunit (RefSeq) | insig. | 26 | 99 |
| | Variovorax sp. OAS795 | ABID97_RS13680 | | nickel-dependent hydrogenase large subunit | insig. | 26 | 100 |
| | Escherichia coli ECRC100 | OKFHMN_04805 | hyaB | Ni/Fe-hydrogenase large subunit | insig. | 26 | 99 |
| | Escherichia coli ECRC101 | MCAODC_24190 | hyaB | Ni/Fe-hydrogenase large subunit | insig. | 26 | 99 |
| | Escherichia coli ECRC102 | NIAGMN_23045 | hyaB | Ni/Fe-hydrogenase large subunit | insig. | 26 | 99 |
| | Escherichia coli ECRC98 | JDDGAC_08415 | hyaB | Ni/Fe-hydrogenase large subunit | insig. | 26 | 99 |
| | Escherichia coli ECRC99 | KEDOAH_22940 | hyaB | Ni/Fe-hydrogenase large subunit | no data | 26 | 99 |
| | Escherichia coli BL21 | ECD_00976 | | hydrogenase 1, large subunit | insig. | 26 | 99 |
| | Escherichia coli ECOR27 | NOLOHH_21710 | hyaB | Ni/Fe-hydrogenase large subunit | insig. | 26 | 99 |
| | Escherichia coli ECOR38 | HEPCGN_23365 | hyaB | Ni/Fe-hydrogenase large subunit | insig. | 26 | 99 |
| | Escherichia coli ECRC62 | BNILDI_19875 | hyaB | Ni/Fe-hydrogenase large subunit | insig. | 26 | 99 |
| | Escherichia coli HS(pFamp)R (ATCC 700891) | OHPLBJKB_02693 | | Hydrogenase-1 large chain | insig. | 26 | 99 |
| | Escherichia coli BW25113 | b0973 | hyaB | hydrogenase 1, large subunit (NCBI) | insig. | 26 | 99 |
| | Escherichia coli Nissle 1917 | ECOLIN_RS05115 | | Ni/Fe-hydrogenase large subunit | no data | 26 | 99 |
| | Escherichia fergusonii Becca | EFB2_03098 | | Hydrogenase-1 large chain | insig. | 26 | 99 |
| | Hydrogenophaga sp. GW460-11-11-14-LB1 | GFF2229 | | Uptake hydrogenase large subunit (EC 1.12.99.6) | insig. | 26 | 100 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF2788 | | Uptake hydrogenase large subunit (EC 1.12.99.6) | insig. | 26 | 99 |
| | Xanthobacter sp. DMC5 | GFF4443 | | Uptake hydrogenase large subunit | insig. | 34 | 47 |
| | Methanococcus maripaludis JJ | MMJJ_RS00865 | | Ni/Fe hydrogenase subunit alpha | insig. | 26 | 99 |
| | Azospirillum sp. SherDot2 | MPMX19_05287 | | Uptake hydrogenase large subunit | insig. | 33 | 47 |
| | Alteromonas macleodii MIT1002 | MIT1002_00275 | | Hydrogenase-1 large chain | insig. | 32 | 42 |
| | Methanococcus maripaludis S2 | MMP_RS04285 | | Ni/Fe hydrogenase subunit alpha | sig. | 26 | 99 |
| | Rhodopseudomonas palustris CGA009 | TX73_004960 | | nickel-dependent hydrogenase large subunit | insig. | 35 | 42 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF2524 | | Uptake hydrogenase large subunit (EC 1.12.99.6) | insig. | 34 | 37 |
| | Rhodospirillum rubrum S1H | Rru_A1162 | | Nickel-dependent hydrogenase, large subunit (NCBI) | insig. | 34 | 42 |
| | Dechlorosoma suillum PS | Dsui_3027 | | coenzyme F420-reducing hydrogenase, alpha subunit | cofit | 25 | 99 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS17180 | | Ni/Fe hydrogenase subunit alpha | insig. | 25 | 99 |
| | Rhodospirillum rubrum S1H | Rru_A1162 | | Nickel-dependent hydrogenase, large subunit (NCBI) | insig. | 36 | 23 |
| | Azospirillum sp. SherDot2 | MPMX19_05720 | | hypothetical protein | no data | 38 | 34 |
| | Synechocystis sp000284455 PCC 6803 | SGL_RS09725 | | Ni/Fe hydrogenase subunit alpha | insig. | 25 | 99 |
| | Synechococcus elongatus PCC 7942 | Synpcc7942_2555 | hoxH | NAD-reducing hydrogenase HoxS beta subunit | insig. | 24 | 99 |
| | Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | GFF2524 | | Uptake hydrogenase large subunit (EC 1.12.99.6) | insig. | 34 | 24 |
| | Rhodopseudomonas palustris CGA009 | TX73_004960 | | nickel-dependent hydrogenase large subunit | insig. | 35 | 23 |
| | Rhodopseudomonas palustris CGA009 | TX73_005005 | | nickel-dependent hydrogenase large subunit | insig. | 37 | 34 |
| | Methanococcus maripaludis S2 | MMP_RS08725 | | Ni/Fe hydrogenase subunit alpha | insig. | 27 | 40 |
| | Methanococcus maripaludis JJ | MMJJ_RS05635 | | Ni/Fe hydrogenase subunit alpha | no data | 27 | 40 |
| | Methanococcus maripaludis JJ | MMJJ_RS00880 | | coenzyme F420 hydrogenase subunit alpha | insig. | 22 | 98 |
| | Methanococcus maripaludis S2 | MMP_RS04270 | | coenzyme F420 hydrogenase subunit alpha | insig. | 22 | 98 |
| | Azospirillum sp. SherDot2 | MPMX19_05287 | | Uptake hydrogenase large subunit | insig. | 32 | 23 |
| | Xanthobacter sp. DMC5 | GFF4443 | | Uptake hydrogenase large subunit | insig. | 30 | 25 |
| | Alteromonas macleodii MIT1002 | MIT1002_00275 | | Hydrogenase-1 large chain | insig. | 29 | 24 |
| | Rhodospirillum rubrum S1H | Rru_A1167 | | putative hydrogenase expression/formation protein HupK (NCBI) | insig. | 39 | 19 |
| | Magnetospirillum magneticum AMB-1 | AMB_RS08320 | | Ni,Fe-hydrogenase I large subunit | insig. | 35 | 23 |
| | Methanococcus maripaludis JJ | MMJJ_RS07235 | | coenzyme F420 hydrogenase subunit alpha | strong | 29 | 23 |
| | Methanococcus maripaludis S2 | MMP_RS07120 | | coenzyme F420 hydrogenase subunit alpha | strong | 29 | 23 |
| | Dechlorosoma suillum PS | Dsui_1165 | | Ni,Fe-hydrogenase I large subunit | cofit | 38 | 17 |
| | Xanthobacter sp. DMC5 | GFF4436 | | hypothetical protein | insig. | 35 | 17 |
| | Variovorax sp. OAS795 | ABID97_RS13635 | | hypothetical protein | insig. | 33 | 34 |