Conservation of cofitness between BWI76_RS19375 and BWI76_RS01545 in Klebsiella michiganensis M5al

38 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Klebsiella michiganensis M5al 1.0 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 1.0 BWI76_RS01545 thiamine biosynthesis protein ThiS 0.25 11
Escherichia coli ECRC98 0.93 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.76 JDDGAC_17010 thiF thiazole biosynthesis adenylyltransferase ThiF low > 86
Escherichia coli ECRC102 0.93 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.76 NIAGMN_11135 thiF thiazole biosynthesis adenylyltransferase ThiF — —
Escherichia coli ECRC101 0.93 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.76 MCAODC_03885 thiF thiazole biosynthesis adenylyltransferase ThiF 0.80 10
Escherichia coli ECRC100 0.93 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.76 OKFHMN_13385 thiF thiazole biosynthesis adenylyltransferase ThiF 0.90 11
Escherichia coli ECRC99 0.93 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.76 KEDOAH_14775 thiF thiazole biosynthesis adenylyltransferase ThiF — —
Escherichia coli ECRC62 0.93 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.76 BNILDI_05995 thiF thiazole biosynthesis adenylyltransferase ThiF 0.75 21
Escherichia coli BW25113 0.93 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.76 b3992 thiF thiamin biosynthesis, thiazole moiety (VIMSS) 0.89 3
Escherichia coli ECOR27 0.93 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.76 NOLOHH_05530 thiF thiazole biosynthesis adenylyltransferase ThiF 0.90 3
Escherichia coli HS(pFamp)R (ATCC 700891) 0.93 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.76 OHPLBJKB_04058 Sulfur carrier protein ThiS adenylyltransferase low > 73
Escherichia fergusonii Becca 0.92 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.76 EFB2_04619 Sulfur carrier protein ThiS adenylyltransferase low > 86
Escherichia coli BL21 0.92 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase 0.76 ECD_03869 adenylyltransferase, modifies ThiS C-terminus 0.47 6
Escherichia coli ECOR38 0.92 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.76 HEPCGN_12020 thiF thiazole biosynthesis adenylyltransferase ThiF 0.84 19
Escherichia coli Nissle 1917 0.91 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.75 ECOLIN_RS23030 thiazole biosynthesis adenylyltransferase ThiF — —
Enterobacter sp. TBS_079 0.90 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.81 MPMX20_00215 Sulfur carrier protein ThiS adenylyltransferase 0.44 13
Enterobacter asburiae PDN3 0.90 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.80 EX28DRAFT_4534 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 low > 76
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.90 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.81 GFF4200 Sulfur carrier protein adenylyltransferase ThiF low > 78
Pectobacterium carotovorum WPP14 0.79 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 HER17_RS20390 HesA/MoeB/ThiF family protein 0.89 8
Serratia liquefaciens MT49 0.77 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.66 IAI46_01310 HesA/MoeB/ThiF family protein low > 86
Rahnella sp. WP5 0.77 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.59 EX31_RS16805 HesA/MoeB/ThiF family protein low > 89
Dickeya dianthicola 67-19 0.76 HGI48_RS15410 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.64 HGI48_RS01160 HesA/MoeB/ThiF family protein 0.70 62
Dickeya dadantii 3937 0.76 DDA3937_RS15335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.68 DDA3937_RS01165 HesA/MoeB/ThiF family protein 0.81 5
Dickeya dianthicola ME23 0.76 DZA65_RS16235 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.65 DZA65_RS01205 HesA/MoeB/ThiF family protein 0.65 56
Erwinia tracheiphila SCR3 0.75 LU632_RS08590 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.66 LU632_RS00960 HesA/MoeB/ThiF family protein low > 74
Castellaniella sp019104865 MT123 0.44 ABCV34_RS14505 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.47 ABCV34_RS14285 HesA/MoeB/ThiF family protein — —
Vibrio cholerae E7946 ATCC 55056 0.40 CSW01_06545 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.40 CSW01_00345 thiazole biosynthesis adenylyltransferase ThiF low > 62
Bacteroides stercoris CC31F 0.38 HMPREF1181_RS14705 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.31 HMPREF1181_RS14695 HesA/MoeB/ThiF family protein 0.65 29
Bacteroides thetaiotaomicron VPI-5482 0.36 BT0790 phosphomethylpyrimidine kinase (NCBI ptt file) 0.32 BT0648 molybdopterin biosynthesis protein (NCBI ptt file) 0.51 2
Ralstonia solanacearum GMI1000 0.36 RS_RS00495 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.40 RS_RS01730 molybdopterin-synthase adenylyltransferase MoeB — —
Ralstonia solanacearum UW163 0.35 UW163_RS03675 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.39 UW163_RS02690 molybdopterin-synthase adenylyltransferase MoeB — —
Ralstonia solanacearum IBSBF1503 0.35 RALBFv3_RS09905 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.39 RALBFv3_RS10890 molybdopterin-synthase adenylyltransferase MoeB — —
Variovorax sp. OAS795 0.35 ABID97_RS15330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.37 ABID97_RS07375 molybdopterin-synthase adenylyltransferase MoeB — —
Bacteroides ovatus ATCC 8483 0.35 BACOVA_02530 phosphomethylpyrimidine kinase 0.32 BACOVA_02356 ThiF family protein 0.93 2
Bifidobacterium breve UCC2003 0.34 BBR_RS17215 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.37 BBR_RS13970 thiazole biosynthesis adenylyltransferase ThiF low > 34
Acidovorax sp. GW101-3H11 0.33 Ac3H11_1063 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.43 Ac3H11_3854 Sulfur carrier protein adenylyltransferase ThiF — —
Cupriavidus basilensis FW507-4G11 0.32 RR42_RS01370 phosphomethylpyrimidine kinase 0.38 RR42_RS01815 molybdopterin biosynthesis protein MoeB — —
Magnetospirillum magneticum AMB-1 0.30 AMB_RS16155 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.33 AMB_RS01000 molybdopterin-synthase adenylyltransferase MoeB — —
Dechlorosoma suillum PS 0.24 Dsui_0662 phosphomethylpyrimidine kinase 0.49 Dsui_1268 dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis — —
Herbaspirillum seropedicae SmR1 0.18 HSERO_RS02135 phosphomethylpyrimidine kinase 0.46 HSERO_RS00835 molybdopterin biosynthesis protein MoeB 0.74 4

Not shown: 50 genomes with orthologs for BWI76_RS19375 only; 6 genomes with orthologs for BWI76_RS01545 only