| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
|---|
| Bacteroides thetaiotaomicron VPI-5482 | 1.0 | BT1607 | | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase (NCBI ptt file) | 1.0 | BT3320 | | dihydrodipicolinate reductase (NCBI ptt file) | 0.73 | 14 |
| Bacteroides stercoris CC31F | 0.97 | HMPREF1181_RS11305 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.85 | HMPREF1181_RS02275 | | 4-hydroxy-tetrahydrodipicolinate reductase | low | > 56 |
| Bacteroides ovatus ATCC 8483 | 0.97 | BACOVA_04344 | | tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein | 0.91 | BACOVA_00959 | | dihydrodipicolinate reductase | 0.79 | 61 |
| Phocaeicola vulgatus CL09T03C04 | 0.96 | HMPREF1058_RS15075 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.86 | HMPREF1058_RS11730 | | 4-hydroxy-tetrahydrodipicolinate reductase | 0.62 | 20 |
| Phocaeicola dorei CL03T12C01 | 0.96 | ABI39_RS10870 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.86 | ABI39_RS05175 | | 4-hydroxy-tetrahydrodipicolinate reductase | 0.61 | 49 |
| Parabacteroides merdae CL09T00C40 | 0.84 | HMPREF1078_RS14700 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.60 | HMPREF1078_RS05545 | | 4-hydroxy-tetrahydrodipicolinate reductase | low | > 61 |
| Pontibacter actiniarum KMM 6156, DSM 19842 | 0.68 | CA264_07145 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.36 | CA264_04750 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Pedobacter sp. GW460-11-11-14-LB5 | 0.65 | CA265_RS08950 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.45 | CA265_RS15670 | | 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) (from data) | — | — |
| Echinicola vietnamensis KMM 6221, DSM 17526 | 0.65 | Echvi_4643 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 0.37 | Echvi_2395 | | 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) (from data) | — | — |
| Mucilaginibacter yixingensis YX-36 DSM 26809 | 0.64 | ABZR88_RS09400 | | bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase | 0.44 | ABZR88_RS02050 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Dechlorosoma suillum PS | 0.44 | Dsui_0093 | | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase | 0.17 | Dsui_3066 | | dihydrodipicolinate reductase | — | — |
| Kangiella aquimarina DSM 16071 | 0.44 | B158DRAFT_1028 | | methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)/5,10-methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) | 0.12 | B158DRAFT_0614 | | dihydrodipicolinate reductase (EC 1.3.1.26) | — | — |
| Dickeya dianthicola ME23 | 0.43 | DZA65_RS15960 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.16 | DZA65_RS19390 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Dickeya dianthicola 67-19 | 0.43 | HGI48_RS15155 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.16 | HGI48_RS18250 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Dickeya dadantii 3937 | 0.43 | DDA3937_RS15075 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.16 | DDA3937_RS18315 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Shewanella sp. ANA-3 | 0.43 | Shewana3_2663 | | methenyltetrahydrofolate cyclohydrolase (RefSeq) | 0.13 | Shewana3_0966 | | dihydrodipicolinate reductase (RefSeq) | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.43 | GFF4447 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.16 | GFF216 | | 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) | — | — |
| Shewanella oneidensis MR-1 | 0.43 | SO1792 | folD | methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase (NCBI ptt file) | 0.13 | SO_1140 | dapB | dihydrodipicolinate reductase (RefSeq) | — | — |
| Escherichia fergusonii Becca | 0.41 | EFB2_03532 | | Bifunctional protein FolD protein | 0.16 | EFB2_04014 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Escherichia coli ECRC99 | 0.41 | KEDOAH_20165 | | Bifunctional protein FolD | 0.16 | KEDOAH_17200 | dapB | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Escherichia coli ECOR38 | 0.41 | HEPCGN_06445 | | Bifunctional protein FolD | 0.16 | HEPCGN_08940 | dapB | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Escherichia coli ECOR27 | 0.41 | NOLOHH_00795 | | Bifunctional protein FolD | 0.15 | NOLOHH_03285 | dapB | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Escherichia coli ECRC102 | 0.41 | NIAGMN_05860 | | Bifunctional protein FolD | 0.16 | NIAGMN_08805 | dapB | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Escherichia coli ECRC98 | 0.41 | JDDGAC_11455 | | Bifunctional protein FolD | 0.16 | JDDGAC_14550 | dapB | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Escherichia coli ECRC101 | 0.41 | OKFHMN_07805 | | Bifunctional protein FolD | 0.16 | OKFHMN_10955 | dapB | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Escherichia coli BW25113 | 0.41 | b0529 | folD | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase (NCBI) | 0.16 | b0031 | dapB | dihydrodipicolinate reductase (NCBI) | — | — |
| Escherichia coli BL21 | 0.41 | ECD_00479 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.15 | ECD_00035 | | dihydrodipicolinate reductase | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.41 | OHPLBJKB_03152 | | Bifunctional protein FolD protein | 0.15 | OHPLBJKB_03626 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Escherichia coli ECRC62 | 0.41 | BNILDI_22225 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.16 | BNILDI_08315 | dapB | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Escherichia coli ECRC101 | 0.41 | MCAODC_27025 | | Bifunctional protein FolD | 0.16 | MCAODC_01470 | dapB | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Escherichia coli Nissle 1917 | 0.41 | ECOLIN_RS03065 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.16 | ECOLIN_RS00160 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Magnetospirillum magneticum AMB-1 | 0.41 | AMB_RS22130 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.17 | AMB_RS22745 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Pseudomonas sp. S08-1 | 0.41 | OH686_03670 | | Methenyltetrahydrofolate cyclohydrolase / Methylenetetrahydrofolate dehydrogenase (NADP+) | 0.18 | OH686_17070 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Enterobacter sp. TBS_079 | 0.41 | MPMX20_01107 | | Bifunctional protein FolD protein | 0.15 | MPMX20_00738 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Caulobacter crescentus NA1000 | 0.41 | CCNA_01275 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.16 | CCNA_03664 | | dihydrodipicolinate reductase | — | — |
| Caulobacter crescentus NA1000 Δfur | 0.41 | CCNA_01275 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.16 | CCNA_03664 | | dihydrodipicolinate reductase | — | — |
| Castellaniella sp019104865 MT123 | 0.41 | ABCV34_RS04175 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.16 | ABCV34_RS07485 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Rhizobium sp. OAE497 | 0.40 | ABIE40_RS03150 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.14 | ABIE40_RS13905 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Brevundimonas sp. GW460-12-10-14-LB2 | 0.40 | A4249_RS06645 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.15 | A4249_RS13645 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
| Mycobacterium tuberculosis H37Rv | 0.35 | Rv3356c | | Probable bifunctional protein FolD: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase | 0.16 | Rv2773c | | Dihydrodipicolinate reductase DapB (DHPR) | — | — |
| Bifidobacterium breve UCC2003 | 0.33 | BBR_RS14270 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.15 | BBR_RS12990 | | 4-hydroxy-tetrahydrodipicolinate reductase | — | — |
Not shown: 61 genomes with orthologs for BT1607 only; 2 genomes with orthologs for BT3320 only