| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_13560 | | methylenetetrahydrofolate reductase | 1.0 | CSW01_14495 | | NUDIX hydrolase | 0.70 | 4 |
| Klebsiella michiganensis M5al | 0.78 | BWI76_RS00805 | | 5,10-methylenetetrahydrofolate reductase | 0.15 | BWI76_RS25960 | | NUDIX hydrolase | low | > 92 |
| Shewanella oneidensis MR-1 | 0.73 | SO4054 | metF | 5,10-methylenetetrahydrofolate reductase (NCBI ptt file) | 0.18 | SO1979 | | MutT/nudix family protein (NCBI ptt file) | low | > 76 |
| Paraburkholderia sabiae LMG 24235 | 0.37 | QEN71_RS28715 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.12 | QEN71_RS35470 | | NUDIX hydrolase | low | > 153 |
| Cupriavidus basilensis FW507-4G11 | 0.35 | RR42_RS01385 | | 5,10-methylenetetrahydrofolate reductase | 0.14 | RR42_RS30640 | | DNA mismatch repair protein MutT | 0.57 | 37 |
| Pseudomonas sp. BP01 | 0.35 | JOY50_RS09810 | metF | methylenetetrahydrofolate reductase [NAD(P)H] | 0.19 | JOY50_RS07905 | | NUDIX domain-containing protein | low | > 84 |
| Pseudomonas simiae WCS417 | 0.35 | PS417_26510 | | 5,10-methylenetetrahydrofolate reductase | 0.12 | PS417_11525 | | ADP-ribose pyrophosphatase | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.35 | Pf6N2E2_4638 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.12 | Pf6N2E2_4223 | | Nudix-related transcriptional regulator NrtR | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.34 | AO353_08015 | | 5,10-methylenetetrahydrofolate reductase | 0.11 | AO353_20500 | | ADP-ribose pyrophosphatase | — | — |
| Pseudomonas fluorescens FW300-N2C3 | 0.34 | AO356_13605 | | 5,10-methylenetetrahydrofolate reductase | 0.11 | AO356_11755 | | ADP-ribose pyrophosphatase | — | — |
| Pseudomonas fluorescens SBW25 | 0.34 | PFLU_RS28165 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.10 | PFLU_RS12115 | | NUDIX hydrolase | low | > 109 |
| Pseudomonas fluorescens SBW25-INTG | 0.34 | PFLU_RS28165 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.10 | PFLU_RS12115 | | NUDIX hydrolase | low | > 109 |
| Ralstonia sp. UNC404CL21Col | 0.34 | ABZR87_RS04865 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.16 | ABZR87_RS21795 | | NUDIX domain-containing protein | low | > 80 |
| Acidovorax sp. GW101-3H11 | 0.33 | Ac3H11_3045 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.14 | Ac3H11_2964 | | Nudix-related transcriptional regulator NrtR | — | — |
| Herbaspirillum seropedicae SmR1 | 0.32 | HSERO_RS21425 | | 5,10-methylenetetrahydrofolate reductase | 0.17 | HSERO_RS22880 | | NUDIX hydrolase | — | — |
| Acinetobacter baumannii LAC-4 | 0.32 | RR41_RS05725 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.16 | RR41_RS13320 | | NUDIX hydrolase | — | — |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.31 | GFF1692 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.16 | GFF1575 | | Nudix-related transcriptional regulator NrtR | — | — |
| Variovorax sp. SCN45 | 0.31 | GFF2055 | | 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) | 0.19 | GFF4790 | | Nudix-related transcriptional regulator NrtR | low | > 127 |
| Cellulophaga baltica 18 | 0.21 | M666_RS08215 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.16 | M666_RS16020 | | NUDIX domain-containing protein | 0.42 | 5 |
| Mucilaginibacter yixingensis YX-36 DSM 26809 | 0.20 | ABZR88_RS20935 | | methylenetetrahydrofolate reductase [NAD(P)H] | 0.14 | ABZR88_RS11560 | | NUDIX domain-containing protein | — | — |
Not shown: 99 genomes with orthologs for CSW01_13560 only; 2 genomes with orthologs for CSW01_14495 only