Conservation of cofitness between GFF119 and GFF4855 in Hydrogenophaga sp. GW460-11-11-14-LB1

15 genomes with putative orthologs of both genes

Organism	Ratio1	Gene1	Name1	Description1	Ratio2	Gene2	Name2	Description2	Cofit	Rank
Hydrogenophaga sp. GW460-11-11-14-LB1	1.0	GFF119		Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives)	1.0	GFF4855		HflC protein	0.71	18
Variovorax sp. OAS795	0.40	ABID97_RS08240		heme biosynthesis HemY N-terminal domain-containing protein	0.76	ABID97_RS14265		protease modulator HflC	low	> 91
Acidovorax sp. GW101-3H11	0.39	Ac3H11_3549		Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives)	0.79	Ac3H11_1802		HflC protein	low	> 79
Variovorax sp. SCN45	0.33	GFF3842		Uncharacterized protein EC-HemY in Proteobacteria (unrelated to HemY-type PPO in GramPositives)	0.76	GFF1003		HflC protein	0.64	126
Paraburkholderia sabiae LMG 24235	0.15	QEN71_RS24940		heme biosynthesis protein HemY	0.32	QEN71_RS06015		protease modulator HflC	low	> 153
Burkholderia phytofirmans PsJN	0.15	BPHYT_RS05240		heme biosynthesis protein HemY	0.31	BPHYT_RS12540		membrane protein	—	—
Herbaspirillum seropedicae SmR1	0.15	HSERO_RS14650		porphyrin biosynthesis protein	0.51	HSERO_RS14760		membrane protein	—	—
Paraburkholderia graminis OAS925	0.14	ABIE53_001317		HemY protein	0.35	ABIE53_002734		membrane protease subunit HflC	low	> 113
Paraburkholderia bryophila 376MFSha3.1	0.14	H281DRAFT_00200		HemY protein	0.34	H281DRAFT_00524		protease FtsH subunit HflC	—	—
Ralstonia sp. UNC404CL21Col	0.14	ABZR87_RS16125		heme biosynthesis protein HemY	0.51	ABZR87_RS10955		protease modulator HflC	low	> 80
Ralstonia solanacearum IBSBF1503	0.14	RALBFv3_RS04235		heme biosynthesis protein HemY	0.53	RALBFv3_RS15315		protease modulator HflC	—	—
Ralstonia solanacearum UW163	0.14	UW163_RS09435		heme biosynthesis protein HemY	0.53	UW163_RS12780		protease modulator HflC	—	—
Ralstonia solanacearum PSI07	0.13	RPSI07_RS13115		heme biosynthesis protein HemY	0.53	RPSI07_RS18060		protease modulator HflC	low	> 81
Cupriavidus basilensis FW507-4G11	0.12	RR42_RS15890		heme biosynthesis protein HemY	0.55	RR42_RS13100		membrane protein	—	—
Ralstonia solanacearum GMI1000	0.12	RS_RS11825		heme biosynthesis protein HemY	0.53	RS_RS06125		protease modulator HflC	—	—
Dechlorosoma suillum PS	0.10	Dsui_1599		putative enzyme of heme biosynthesis	0.50	Dsui_3134		membrane protease subunit, stomatin/prohibitin	—	—

Not shown: 0 genomes with orthologs for GFF119 only; 69 genomes with orthologs for GFF4855 only