| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_00600 | | heme biosynthesis operon protein HemX | 1.0 | CSW01_12885 | | fructose 1,6-bisphosphatase | 0.70 | 13 |
| Pantoea agglomerans CFBP13505 P0401 | 0.26 | PagCFBP13505_RS15415 | | uroporphyrinogen-III C-methyltransferase | 0.74 | PagCFBP13505_RS11345 | | class 1 fructose-bisphosphatase | low | > 74 |
| Pantoea sp. MT58 | 0.26 | IAI47_18435 | | uroporphyrinogen-III C-methyltransferase | 0.74 | IAI47_02750 | | class 1 fructose-bisphosphatase | low | > 76 |
| Serratia liquefaciens MT49 | 0.26 | IAI46_00685 | | uroporphyrinogen-III C-methyltransferase | 0.76 | IAI46_01795 | | class 1 fructose-bisphosphatase | low | > 87 |
| Erwinia tracheiphila SCR3 | 0.25 | LU632_RS24170 | hemX | uroporphyrinogen-III C-methyltransferase | 0.75 | LU632_RS02130 | fbp | class 1 fructose-bisphosphatase | — | — |
| Erwinia tracheiphila HP pepo 2.2 | 0.25 | IJEDHG_08810 | hemX | uroporphyrinogen-III C-methyltransferase | 0.75 | IJEDHG_06785 | fbp | class 1 fructose-bisphosphatase | — | — |
| Rahnella sp. WP5 | 0.24 | EX31_RS15135 | | uroporphyrinogen-III C-methyltransferase | 0.75 | EX31_RS08670 | | class 1 fructose-bisphosphatase | low | > 89 |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.24 | GFF227 | | Homolog of E. coli HemX protein | 0.76 | GFF880 | | Fructose-1,6-bisphosphatase, type I (EC 3.1.3.11) | low | > 78 |
| Erwinia amylovora T8 | 0.24 | OLJFJH_06380 | | uroporphyrinogen-III C-methyltransferase | 0.75 | OLJFJH_02370 | | class 1 fructose-bisphosphatase | — | — |
| Pectobacterium carotovorum WPP14 | 0.24 | HER17_RS01305 | | uroporphyrinogen-III C-methyltransferase | 0.76 | HER17_RS02620 | | class 1 fructose-bisphosphatase | low | > 75 |
| Dickeya dianthicola 67-19 | 0.23 | HGI48_RS20085 | | uroporphyrinogen-III C-methyltransferase | 0.76 | HGI48_RS18510 | | class 1 fructose-bisphosphatase | low | > 71 |
| Dickeya dianthicola ME23 | 0.23 | DZA65_RS21130 | | uroporphyrinogen-III C-methyltransferase | 0.76 | DZA65_RS19645 | | class 1 fructose-bisphosphatase | low | > 75 |
| Dickeya dadantii 3937 | 0.23 | DDA3937_RS19930 | | uroporphyrinogen-III C-methyltransferase | 0.75 | DDA3937_RS18575 | | class 1 fructose-bisphosphatase | low | > 74 |
| Shewanella amazonensis SB2B | 0.22 | Sama_3256 | | hemX protein (RefSeq) | 0.37 | Sama_0599 | | fructose-1,6-bisphosphatase (RefSeq) | — | — |
| Alteromonas macleodii MIT1002 | 0.21 | MIT1002_00100 | | Putative uroporphyrinogen-III C-methyltransferase | 0.35 | MIT1002_00169 | | Fructose-1,6-bisphosphatase class 1 | — | — |
| Shewanella sp. ANA-3 | 0.19 | Shewana3_0384 | | protein of unknown function DUF513, hemX (RefSeq) | 0.35 | Shewana3_0648 | | fructose-1,6-bisphosphatase (RefSeq) | low | > 73 |
| Shewanella loihica PV-4 | 0.19 | Shew_0316 | | protein of unknown function DUF513, hemX (RefSeq) | 0.35 | Shew_0773 | | fructose-1,6-bisphosphatase (RefSeq) | — | — |
| Dechlorosoma suillum PS | 0.12 | Dsui_1600 | | putative enzyme of heme biosynthesis | 0.41 | Dsui_1563 | | fructose-1,6-bisphosphatase | — | — |
| Pseudomonas stutzeri RCH2 | 0.10 | Psest_3746 | | Uncharacterized enzyme of heme biosynthesis | 0.39 | Psest_3956 | | Fructose-1,6-bisphosphatase | — | — |
| Pseudomonas segetis P6 | 0.10 | ACVTMO_RS22425 | | uroporphyrinogen-III C-methyltransferase | 0.40 | ACVTMO_RS21205 | | class 1 fructose-bisphosphatase | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.09 | PfGW456L13_858 | | Uroporphyrinogen-III synthase (EC 4.2.1.75) | 0.39 | PfGW456L13_335 | | Fructose-1,6-bisphosphatase, type I (EC 3.1.3.11) | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.09 | Pf1N1B4_2187 | | Uroporphyrinogen-III synthase (EC 4.2.1.75) | 0.39 | Pf1N1B4_1596 | | Fructose-1,6-bisphosphatase, type I (EC 3.1.3.11) | — | — |
| Pseudomonas simiae WCS417 | 0.08 | PS417_27520 | | uroporphyrin-III methyltransferase | 0.38 | PS417_01690 | | fructose 1,6-bisphosphatase | — | — |
Not shown: 0 genomes with orthologs for CSW01_00600 only; 81 genomes with orthologs for CSW01_12885 only