| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_09855 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 1.0 | CSW01_12340 | | bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase | 0.60 | 14 |
| Pectobacterium carotovorum WPP14 | 0.39 | HER17_RS15550 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 0.70 | HER17_RS04040 | | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Dickeya dianthicola 67-19 | 0.39 | HGI48_RS05965 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 0.68 | HGI48_RS17150 | | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Dickeya dianthicola ME23 | 0.38 | DZA65_RS06300 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 0.68 | DZA65_RS18235 | | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Dickeya dadantii 3937 | 0.37 | DDA3937_RS05920 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 0.68 | DDA3937_RS17100 | | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Rahnella sp. WP5 | 0.36 | EX31_RS19350 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 0.69 | EX31_RS08140 | | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | low | > 89 |
| Serratia liquefaciens MT49 | 0.36 | IAI46_17555 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 0.70 | IAI46_22055 | | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.35 | GFF1869 | | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate synthase (EC 4.2.99.20) | 0.69 | GFF3166 | | ADP-heptose synthase (EC 2.7.-.-) / D-glycero-beta-D-manno-heptose 7-phosphate kinase | low | > 78 |
| Klebsiella pneumoniae MKP103 | 0.35 | KDGMDA_26985 | | 2-succinyl-6-hydroxy-2 4-cyclohexadiene-1-carboxylate synthase | 0.68 | KDGMDA_05265 | | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Escherichia coli ECRC62 | 0.35 | BNILDI_13480 | menH | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxy late synthase | 0.69 | BNILDI_00995 | hldE | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Escherichia coli ECOR27 | 0.35 | NOLOHH_14565 | menH | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxy late synthase | 0.69 | NOLOHH_10520 | hldE | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Escherichia coli ECRC102 | 0.35 | NIAGMN_20710 | menH | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxy late synthase | 0.69 | NIAGMN_16500 | hldE | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Klebsiella pneumoniae MRSN742743 | 0.35 | GJGHJB_01505 | menH | 2-succinyl-6-hydroxy-2 4-cyclohexadiene-1-carboxylate synthase | 0.68 | GJGHJB_00661 | hldE | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Escherichia coli ECRC98 | 0.35 | JDDGAC_26905 | menH | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxy late synthase | 0.69 | JDDGAC_22370 | hldE | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Escherichia coli ECRC101 | 0.35 | MCAODC_13980 | menH | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxy late synthase | 0.69 | MCAODC_09250 | hldE | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.35 | OHPLBJKB_01447 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 0.69 | OHPLBJKB_00652 | | Bifunctional protein HldE | — | — |
| Escherichia coli ECRC100 | 0.35 | OKFHMN_22940 | menH | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxy late synthase | 0.69 | OKFHMN_18735 | hldE | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Escherichia coli ECRC99 | 0.35 | KEDOAH_05255 | menH | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxy late synthase | 0.69 | KEDOAH_09410 | hldE | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Escherichia coli BW25113 | 0.34 | b2263 | yfbB | predicted peptidase (NCBI) | 0.69 | b3052 | rfaE | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | low | > 76 |
| Escherichia coli BL21 | 0.34 | ECD_02190 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 0.69 | ECD_02922 | | heptose 7-phosphate kinase and heptose 1-phosphate adenyltransferase | — | — |
| Escherichia fergusonii Becca | 0.34 | EFB2_01592 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 0.69 | EFB2_00759 | | Bifunctional protein HldE | — | — |
| Escherichia coli Nissle 1917 | 0.34 | ECOLIN_RS13180 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 0.69 | ECOLIN_RS17615 | | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Escherichia coli ECOR38 | 0.34 | HEPCGN_22155 | menH | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxy late synthase | 0.69 | HEPCGN_17590 | hldE | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Erwinia tracheiphila HP pepo 2.2 | 0.33 | IJEDHG_18175 | menH | 2-succinyl-6-hydroxy-2 4-cyclohexadiene-1-carboxylate synthase | 0.69 | IJEDHG_14390 | hldE | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Erwinia tracheiphila SCR3 | 0.33 | LU632_RS08110 | menH | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 0.69 | LU632_RS20670 | hldE | bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE | — | — |
| Klebsiella michiganensis M5al | 0.32 | BWI76_RS20070 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 0.68 | BWI76_RS24455 | | bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase | — | — |
| Enterobacter sp. TBS_079 | 0.32 | MPMX20_03199 | | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | 0.69 | MPMX20_03889 | | Bifunctional protein HldE | — | — |
| Enterobacter asburiae PDN3 | 0.32 | EX28DRAFT_0341 | | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase | 0.68 | EX28DRAFT_3080 | | rfaE bifunctional protein, domain I/rfaE bifunctional protein, domain II | — | — |
| Shewanella loihica PV-4 | 0.26 | Shew_3600 | | alpha/beta hydrolase fold (RefSeq) | 0.63 | Shew_0659 | | bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (RefSeq) | low | > 60 |
| Shewanella oneidensis MR-1 | 0.26 | SO4574 | | hydrolase, alpha/beta fold family (NCBI ptt file) | 0.64 | SO3745 | rfaE | ADP-heptose synthase (NCBI ptt file) | low | > 76 |
| Shewanella amazonensis SB2B | 0.25 | Sama_3461 | | alpha/beta fold family hydrolase (RefSeq) | 0.61 | Sama_0731 | | bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (RefSeq) | — | — |
Not shown: 0 genomes with orthologs for CSW01_09855 only; 39 genomes with orthologs for CSW01_12340 only