Conservation of cofitness between b3368 and b2026 in Escherichia coli BW25113

32 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Escherichia coli BW25113 1.0 b3368 cysG fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) 1.0 b2026 hisI bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) 0.92 20
Escherichia coli BL21 1.00 ECD_03219 fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase 1.00 ECD_01928 phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase low > 60
Escherichia coli HS(pFamp)R (ATCC 700891) 1.00 OHPLBJKB_00334 Siroheme synthase 0.96 OHPLBJKB_01674 Histidine biosynthesis bifunctional protein HisIE low > 73
Escherichia fergusonii Becca 1.00 EFB2_00454 Siroheme synthase 0.98 EFB2_01830 Histidine biosynthesis bifunctional protein HisIE low > 86
Escherichia coli ECRC99 1.00 KEDOAH_10960 cysG siroheme synthase CysG 0.99 KEDOAH_03665 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC98 1.00 JDDGAC_20810 cysG siroheme synthase CysG 0.99 JDDGAC_28595 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC101 1.00 OKFHMN_17180 cysG siroheme synthase CysG 0.99 OKFHMN_24485 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC101 1.00 MCAODC_07710 cysG siroheme synthase CysG 0.99 MCAODC_20455 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC102 1.00 NIAGMN_14950 cysG siroheme synthase CysG 0.99 NIAGMN_22430 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli Nissle 1917 1.00 ECOLIN_RS19285 siroheme synthase CysG 0.99 ECOLIN_RS11975 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECRC62 1.00 BNILDI_02540 cysG siroheme synthase CysG 0.98 BNILDI_14710 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE — —
Escherichia coli ECOR38 1.00 HEPCGN_16010 cysG siroheme synthase CysG 0.99 HEPCGN_03190 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 85
Escherichia coli ECOR27 1.00 NOLOHH_08980 cysG siroheme synthase CysG 0.92 NOLOHH_15800 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 57
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.92 GFF3700 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) 0.89 GFF3906 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) low > 78
Enterobacter asburiae PDN3 0.89 EX28DRAFT_4160 uroporphyrin-III C-methyltransferase 0.91 EX28DRAFT_0533 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19)/phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) 0.59 28
Enterobacter sp. TBS_079 0.89 MPMX20_04271 Siroheme synthase 0.91 MPMX20_03008 Histidine biosynthesis bifunctional protein HisIE 0.30 51
Klebsiella michiganensis M5al 0.88 BWI76_RS26055 siroheme synthase 0.87 BWI76_RS18955 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase 0.75 43
Pectobacterium carotovorum WPP14 0.72 HER17_RS01835 siroheme synthase CysG 0.70 HER17_RS12260 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 75
Serratia liquefaciens MT49 0.71 IAI46_23670 uroporphyrinogen-III C-methyltransferase 0.76 IAI46_08180 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 86
Rahnella sp. WP5 0.71 EX31_RS04680 uroporphyrinogen-III C-methyltransferase 0.76 EX31_RS11470 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 89
Erwinia tracheiphila SCR3 0.53 LU632_RS06420 cysG siroheme synthase CysG 0.76 LU632_RS08915 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 74
Dickeya dianthicola 67-19 0.51 HGI48_RS17000 uroporphyrinogen-III C-methyltransferase 0.80 HGI48_RS09715 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 71
Dickeya dadantii 3937 0.51 DDA3937_RS16930 uroporphyrinogen-III C-methyltransferase 0.81 DDA3937_RS09705 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.90 15
Dickeya dianthicola ME23 0.50 DZA65_RS18075 uroporphyrinogen-III C-methyltransferase 0.80 DZA65_RS10025 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.78 26
Pantoea sp. MT58 0.50 IAI47_04175 uroporphyrinogen-III C-methyltransferase 0.81 IAI47_07060 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.85 18
Acinetobacter radioresistens SK82 0.45 MPMX26_00706 Siroheme synthase 0.31 MPMX26_00264 Histidine biosynthesis bifunctional protein HisIE — —
Alteromonas macleodii MIT1002 0.45 MIT1002_00665 Siroheme synthase 0.63 MIT1002_02639 Phosphoribosyl-ATP pyrophosphatase — —
Dyella japonica UNC79MFTsu3.2 0.44 ABZR86_RS05880 siroheme synthase CysG 0.54 ABZR86_RS06700 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.86 39
Lysobacter sp. OAE881 0.43 ABIE51_RS15855 siroheme synthase CysG 0.47 ABIE51_RS13295 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.95 38
Rhodanobacter sp. FW510-T8 0.40 OKGIIK_05980 cysG siroheme synthase CysG 0.55 OKGIIK_04980 hisIE bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 52
Rhodanobacter denitrificans FW104-10B01 0.38 LRK54_RS00910 siroheme synthase CysG 0.55 LRK54_RS01575 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.70 12
Rhodanobacter denitrificans MT42 0.37 LRK55_RS00685 siroheme synthase CysG 0.56 LRK55_RS01355 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE low > 63
Brevundimonas sp. GW460-12-10-14-LB2 0.31 A4249_RS09675 siroheme synthase CysG 0.46 A4249_RS10720 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE 0.99 33

Not shown: 24 genomes with orthologs for b3368 only; 17 genomes with orthologs for b2026 only