Conservation of cofitness between b1829 and b4484 in Escherichia coli BW25113

22 genomes with putative orthologs of both genes

Organism	Ratio1	Gene1	Name1	Description1	Ratio2	Gene2	Name2	Description2	Cofit	Rank
Escherichia coli BW25113	1.0	b1829	htpX	heat shock protein HtpX (NCBI)	1.0	b4484	cpxP	periplasmic protein combats stress (NCBI)	0.29	3
Escherichia coli ECOR38	1.00	HEPCGN_04870	htpX	protease HtpX	1.00	HEPCGN_12485	cpxP	cell-envelope stress modulator CpxP	low	> 85
Escherichia fergusonii Becca	1.00	EFB2_02172		Protease HtpX	1.00	EFB2_04704		Periplasmic protein CpxP	low	> 86
Escherichia coli ECRC101	1.00	OKFHMN_26470	htpX	protease HtpX	1.00	OKFHMN_13840	cpxP	cell-envelope stress modulator CpxP	—	—
Escherichia coli HS(pFamp)R (ATCC 700891)	1.00	OHPLBJKB_01902		Protease HtpX	1.00	OHPLBJKB_04137		Periplasmic protein CpxP	low	> 73
Escherichia coli ECRC99	1.00	KEDOAH_01635	htpX	protease HtpX	1.00	KEDOAH_14315	cpxP	cell-envelope stress modulator CpxP	—	—
Escherichia coli ECRC102	1.00	NIAGMN_01590	htpX	protease HtpX	1.00	NIAGMN_11595	cpxP	cell-envelope stress modulator CpxP	—	—
Escherichia coli ECRC101	1.00	MCAODC_18935	htpX	protease HtpX	1.00	MCAODC_04340	cpxP	cell-envelope stress modulator CpxP	—	—
Escherichia coli ECRC62	1.00	BNILDI_15775	htpX	protease HtpX	1.00	BNILDI_05550	cpxP	cell-envelope stress modulator CpxP	—	—
Escherichia coli ECRC98	1.00	JDDGAC_01045	htpX	protease HtpX	1.00	JDDGAC_17465	cpxP	cell-envelope stress modulator CpxP	—	—
Escherichia coli Nissle 1917	1.00	ECOLIN_RS10185		protease HtpX	1.00	ECOLIN_RS22545		cell-envelope stress modulator CpxP	—	—
Escherichia coli ECOR27	1.00	NOLOHH_16980	htpX	protease HtpX	1.00	NOLOHH_05975	cpxP	cell-envelope stress modulator CpxP	—	—
Escherichia coli BL21	0.99	ECD_01800		putative endopeptidase	0.99	ECD_03799		inhibitor of the cpx response; periplasmic adaptor protein	low	> 60
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868	0.97	GFF2844		Probable protease HtpX (EC 3.4.24.-)	0.81	GFF2281		P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein	—	—
Enterobacter sp. TBS_079	0.96	MPMX20_02736		Protease HtpX	0.73	MPMX20_04555		Periplasmic protein CpxP	low	> 85
Enterobacter asburiae PDN3	0.95	EX28DRAFT_0727		Zn-dependent protease with chaperone function	0.73	EX28DRAFT_4388		P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein	0.48	58
Klebsiella michiganensis M5al	0.94	BWI76_RS17970		zinc metalloprotease HtpX	0.76	BWI76_RS00725		periplasmic repressor CpxP	low	> 92
Pantoea sp. MT58	0.90	IAI47_08710		protease HtpX	0.46	IAI47_00765		cell-envelope stress modulator CpxP	0.46	72
Rahnella sp. WP5	0.89	EX31_RS24885		protease HtpX	0.46	EX31_RS14315		periplasmic heavy metal sensor	—	—
Dickeya dadantii 3937	0.88	DDA3937_RS11460		protease HtpX	0.43	DDA3937_RS00785		cell-envelope stress modulator CpxP	low	> 74
Serratia liquefaciens MT49	0.88	IAI46_10810		protease HtpX	0.46	IAI46_24655		cell-envelope stress modulator CpxP	—	—
Erwinia tracheiphila SCR3	0.87	LU632_RS13240	htpX	protease HtpX	0.46	LU632_RS21850	cpxP	cell-envelope stress modulator CpxP	—	—
Dickeya dianthicola ME23	0.87	DZA65_RS11840		protease HtpX	0.43	DZA65_RS21605		stress resistance protein	0.54	2

Not shown: 60 genomes with orthologs for b1829 only; 0 genomes with orthologs for b4484 only