Pairwise Alignments
Query, 1298 a.a., phosphoribosylformylglycinamidine synthase from Pseudomonas fluorescens FW300-N2E3
Subject, 754 a.a., Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II) from Mycobacterium tuberculosis H37Rv
Score = 172 bits (435), Expect = 1e-46
Identities = 200/763 (26%), Positives = 321/763 (42%), Gaps = 129/763 (16%)
Query: 195 LKRNPHDIELMMFAQANSEHCRHKIFNASWDIDGESQEKSLFGMIKNTYVMHSEGVLSAY 254
L R P D EL M++ SEHC +K GE+ + +L+
Sbjct: 35 LGRRPTDTELAMYSVMWSEHCSYKSSKVHLRYFGETTSDEM-----------RAAMLAGI 83
Query: 255 KDNASVIVGSVAGRFFPDPETRQYGAVQEPVHILMKVETHNHPTAIAPFPGASTGSGGEI 314
+NA V+ + + + KVE+HNHP+ + P+ GA+TG GG +
Sbjct: 84 GENAGVV------------------DIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIV 125
Query: 315 RDEGATGRGAKPKAGLTGFTVSNLQIPGFEQPWEVPYGKPERIVTALDIMIEGPLGGAAF 374
RD A G A+P A + P + LD ++ G +GG +
Sbjct: 126 RDIMAMG--ARPVAVMDQLRFGAADAPDTRR--------------VLDGVVRG-IGG--Y 166
Query: 375 NNEFGRPALTGYFRTFEQSITTP--RGDEVRGYHKPIMLAGGMGNIREEHVKKGEIL-VG 431
N G P + G +++ P G+ P++ A +G +R+E + G
Sbjct: 167 GNSLGLPNIGG------ETVFDPCYAGN-------PLVNALCVGVLRQEDLHLAFASGAG 213
Query: 432 SKLIVLGGPAMLIGLGGGAASSMATGTSSAD---LDFASVQRENPEMERRCQEVIDRCWQ 488
+K+I+ G L G+GG S +A+ T A+ SVQ +P ME+ +I+ C +
Sbjct: 214 NKIILFGARTGLDGIGG--VSVLASDTFDAEGSRKKLPSVQVGDPFMEK---VLIECCLE 268
Query: 489 LGERNPISFIHDVGAGGLSNAFPELVNDGDRGGRFELRNIPNDEPGMAPHEIWSNESQER 548
L + I D+G GLS A EL + GD G +L ++P M P E+ +ESQER
Sbjct: 269 LYAGGLVIGIQDLGGAGLSCATSELASAGDGGMTIQLDSVPLRAKEMTPAEVLCSESQER 328
Query: 549 YVLAVGPADFERFKAICERERCPFAVVGEATAEPQLTVTDSHFGNSPVDMPLEVLLGKAP 608
V P + + F A+C + V+GE T +L +T G + VD+P + + P
Sbjct: 329 MCAVVSPKNVDAFLAVCRKWEVLATVIGEVTDGDRLQIT--WHGETVVDVPPRTVAHEGP 386
Query: 609 RMHRSAVR-ETE---------------LGDDFDPSTLAIADCVERVLHHPAVASKSFLIT 652
R R +T+ GD+ + LA+ L P + S++F+
Sbjct: 387 VYQRPVARPDTQDALNADRSAKLSRPVTGDELRATLLAL-------LGSPHLCSRAFITE 439
Query: 653 IGDRTITGLVARDQMVGPWQVPVADVAVTATSFDVYTGEAMAMGERTPLALLDAPASGRM 712
DR + G + AD + G A++ LLD A ++
Sbjct: 440 QYDRYVRGNTVLAEH--------ADGGMLRIDESTGRGIAVSTDASGRYTLLDPYAGAQL 491
Query: 713 AIGETLTNIAASRIGKISDIKLSANWMSAAGHPGEDARLYDTVKAVG--MELCPELGITI 770
A+ E N+A + ++ + N+ G P + ++ +AV + C +LGI +
Sbjct: 492 ALAEAYRNVAVTGATPVA-VTNCLNF----GSPEDPGVMWQFTQAVRGLADGCADLGIPV 546
Query: 771 PVGKDSMSMATRWNDEGVDKTVTSPMSLIVTGFAPVTDIRQTLTPQLRMDKGTTDLILID 830
G S +N G + +P +V + D+R+ + L + G T L+
Sbjct: 547 TGGNVSF-----YNQTGSAAILPTP---VVGVLGVIDDVRRRIPTGLGAEPGET---LML 595
Query: 831 LGRGQNRMGASILAQVHG-KLGKQAPDVDDAEDLKAFFAVIQGLNADGHLLAYHDRSDGG 889
LG ++ S+ AQV LG P VD A + K AV+ + DG + A HD S+GG
Sbjct: 596 LGDTRDEFDGSVWAQVTADHLGGLPPVVDLARE-KLLAAVLSSASRDGLVSAAHDLSEGG 654
Query: 890 LLTSVVEMAFAGHCGLSLNLDGLAETSADIAAILFNEELGAVI 932
L ++VE A AG G + L AD +LF+E G V+
Sbjct: 655 LAQAIVESALAGETGCRIVL----PEGADPFVLLFSESAGRVL 693
Score = 38.9 bits (89), Expect = 2e-06
Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 6/82 (7%)
Query: 495 ISFIHDVGAGGLSNAFPELVNDGDRGGRFELRNIPNDEPGMAPHEIWSNESQERYVLAVG 554
+S HD+ GGL+ A E G+ G R L G P + +ES R ++AV
Sbjct: 644 VSAAHDLSEGGLAQAIVESALAGETGCRIVLPE------GADPFVLLFSESAGRVLVAVP 697
Query: 555 PADFERFKAICERERCPFAVVG 576
+ RF+ +CE P +G
Sbjct: 698 RTEESRFRGMCEARGLPAVRIG 719
Score = 33.9 bits (76), Expect = 6e-05
Identities = 27/112 (24%), Positives = 52/112 (46%), Gaps = 11/112 (9%)
Query: 873 LNADGHLLAYHDRSDGGLLTSVVEMAFAGHCGLSLNLDGLA-----ETSADIAAILFNEE 927
L A G ++ D GL + E+A AG G+++ LD + T A++ E
Sbjct: 269 LYAGGLVIGIQDLGGAGLSCATSELASAGDGGMTIQLDSVPLRAKEMTPAEVLCSESQER 328
Query: 928 LGAVIQVRQ-DSTPDILAQFSAAGLGDCVSVIGQPMNNGEISITFNGDTVFE 978
+ AV+ + D+ + ++ +VIG+ + + IT++G+TV +
Sbjct: 329 MCAVVSPKNVDAFLAVCRKWEVLA-----TVIGEVTDGDRLQITWHGETVVD 375