Pairwise Alignments

Query, 482 a.a., phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating) from Vibrio cholerae E7946 ATCC 55056

Subject, 485 a.a., Probable 6-phosphogluconate dehydrogenase Gnd1 from Mycobacterium tuberculosis H37Rv

 Score =  463 bits (1191), Expect = e-135
 Identities = 236/468 (50%), Positives = 321/468 (68%), Gaps = 6/468 (1%)

Query: 5   IGVIGLAVMGQNLILNMNDHGFKVVAHNRTAAKVDEFLEGPAKGTNIVGAYTLQELVDKL 64
           IGV GLAVMG N+  N   HG+ V  HNR+ AK D  L+  +     V + T+ E +  L
Sbjct: 13  IGVTGLAVMGSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFVRSETIPEFLAAL 72

Query: 65  ATPRKVMLMVRAGQVVDD--FIEQLVPLLDKGDIIIDGGNTNFPDTNRRVKALREKGIHF 122
             PR+V++MV+AG+  D    I +L   ++ GDIIIDGGN  + DT RR KA+RE+G+HF
Sbjct: 73  EKPRRVLIMVKAGEATDADAVINELADAMEPGDIIIDGGNALYTDTMRREKAMRERGLHF 132

Query: 123 IGTGVSGGEEGARFGPSIMPGGAPEAWEAVKPIFQGISAKTDAGEPCCDWVGNDGAGHFV 182
           +G G+SGGEEGA  GPSIMPGG  E+++++ P+ + ISA  D G PCC  +G DG+GHFV
Sbjct: 133 VGAGISGGEEGALNGPSIMPGGPAESYQSLGPLLEEISAHVD-GVPCCTHIGPDGSGHFV 191

Query: 183 KMVHNGIEYGDMQLITEAYQFMKDGLGMSADEMQAVFADWNKTELDSYLVEITADILGYK 242
           KMVHNGIEY DMQLI EAYQ M+DGLG++A  +  VF +WN  +LDSYLVEITA++L   
Sbjct: 192 KMVHNGIEYSDMQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYLVEITAEVLRQT 251

Query: 243 D-EDGEALVEKILDTAGQKGTGKWTGINALDMGIPLTLITESVFSRCLSALKDQRVEAEK 301
           D + G+ LV+ I+D A QKGTG+WT  +ALD+G+P+T I E+VF+R LS    QR  A  
Sbjct: 252 DAKTGKPLVDVIVDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVGQRSAASG 311

Query: 302 LFGKTKTQVEGDKQVWVDALRQALLASKIISYAQGFMLMREASNENGWNLNYGNVALMWR 361
           L      +   D   + + +RQAL ASKI++YAQGF  ++  S E GW++  G++A +WR
Sbjct: 312 LASGKLGEQPADPATFTEDVRQALYASKIVAYAQGFNQIQAGSAEFGWDITPGDLATIWR 371

Query: 362 GGCIIRSAFLGNIRDAFEKNPELAFLGSDAYFKGILDNCLAAWRKVAAKSLEVGIPMPCT 421
           GGCIIR+ FL +I++AF+ +P LA L    YF+G +++ + +WR+V + + ++GIP P  
Sbjct: 372 GGCIIRAKFLNHIKEAFDASPNLASLIVAPYFRGAVESAIDSWRRVVSTAAQLGIPTPGF 431

Query: 422 TSALTFLDGYTTARLPANLLQAQRDYFGAHTYERIDRPRGEFFHTNWT 469
           +SAL++ D   TARLPA L QAQRD+FGAHTY RID P    FHT W+
Sbjct: 432 SSALSYYDALRTARLPAALTQAQRDFFGAHTYGRIDEPGK--FHTLWS 477