Pairwise Alignments

Query, 436 a.a., 3-hydroxy-3-methylglutaryl-CoA reductase from Vibrio cholerae E7946 ATCC 55056

Subject, 408 a.a., hydroxymethylglutaryl-CoA reductase (NADPH) from Methanococcus maripaludis S2

 Score =  289 bits (739), Expect = 1e-82
 Identities = 164/380 (43%), Positives = 229/380 (60%), Gaps = 11/380 (2%)

Query: 62  LTEQQVMKRWQKLAAPEAQALLLDEQTERTMQAYQKNIEYFIGTVKLPVGIAGPLRVNGS 121
           +  ++ +++   +     Q   LDE+      A QKNIE  IG V++P+G AGP+ +NG 
Sbjct: 35  IARRKYVEKLSNVETRHIQEYTLDEKL-----AMQKNIENMIGAVQIPLGFAGPISINGK 89

Query: 122 HAQGDYLVPLATTEAALVASYHRGSQLITAAGGASALLLNEGVTRTPVFAFLSLAQAGQF 181
           +AQG++ VPLATTE ALVAS +RG  +IT  GGA+  ++++ +TR P+    S+  A + 
Sbjct: 90  YAQGEFNVPLATTEGALVASINRGCSIITKCGGATVRVIDDKMTRAPIIKTNSVVDALKL 149

Query: 182 VGWVTSQFEQMKEIAQSTTAHGKLKDIQ-VNIEGNHVYLVFEYTTGDASGQNMVTIATHA 240
             W+   F ++KEIA+STT HGKL  I  + I G +VY  F + TGDA G NMVTIAT  
Sbjct: 150 KEWILDNFAKIKEIAESTTRHGKLIQISPILIVGRNVYPRFTFKTGDAMGMNMVTIATEK 209

Query: 241 VFEFI---MRHSPVAPVQAFLDGNLSGDKKANSYTLRSVRGKKVSAEVHLSAELVKKYLH 297
              FI   ++   +      L GN+  DKK  +  L   RGK V AEV L  E V+KYL 
Sbjct: 210 ACSFIESELKKEGIIIDTVALSGNVCVDKKPAAINLIEGRGKSVVAEVFLKEEYVEKYLK 269

Query: 298 TTPEQMVQFG-QMTTVGGALSGAIGVNAHYANALAALYIACGQDAACVAESAIGMTRMEI 356
           TT + + Q       +G A+S ++G NA YAN + AL++A GQD A + E ++G+T  E 
Sbjct: 270 TTSKAIEQVNTYKNLIGSAISSSLGFNAQYANIVGALFLATGQDEAHIVEGSMGITTAEC 329

Query: 357 HPHGGLYASVTLPNLMVGTVGGGTHLPSQHACLSLMGLAGQGHARALAEVAAALCLAGEL 416
               GLY SVTLP+L V T+GGGT + +Q  CL ++G AG   A   AE+A A  LAGEL
Sbjct: 330 -TGDGLYFSVTLPDLPVATIGGGTRVETQRECLEILGCAGAEKAVKFAEIAGAAVLAGEL 388

Query: 417 SIVGAFCAGHFSRAHHKLAR 436
           S++GA  AGH ++AH +L R
Sbjct: 389 SLIGALAAGHLAKAHSELGR 408