Pairwise Alignments

Query, 705 a.a., bifunctional GTP diphosphokinase/guanosine-3',5'-bis(diphosphate) 3'-diphosphatase from Vibrio cholerae E7946 ATCC 55056

Subject, 747 a.a., (p)ppGpp synthetase, RelA/SpoT family from Pseudomonas stutzeri RCH2

 Score =  432 bits (1111), Expect = e-125
 Identities = 238/717 (33%), Positives = 405/717 (56%), Gaps = 41/717 (5%)

Query: 22  ALRQSYVVARDAHEGQTR-----SSGEPYIIHPVAVARILAEMRLDLETLQAALLHDVIE 76
           AL+++   AR+A +         S G       + +A ILA+++LD ++L AA+++  + 
Sbjct: 36  ALKEACEFAREAEQQANAAQNLWSEGTSSYQIGLEIAEILADLKLDQDSLVAAVIYRGVR 95

Query: 77  DCDVTKEDLDAHFGSSVAELVDGVSKLDKLK--FRDRK------EAQAENFRKMVLAMVQ 128
           +  +   D++  FGS VA+L++GV ++  +      R+      +AQ EN RKM++AMV 
Sbjct: 96  EGKIQLADVNQRFGSVVAKLIEGVLRMAAISASLNPRESLVLGSQAQVENLRKMLVAMVD 155

Query: 129 DIRVILIKLADRTHNMRTLGALRPDKKRRIARETLEIYAPLAHRLGIHNIKTELEELGFE 188
           D+RV LIKLA+RT  +R +     +K++R+ARE  +IYAPLAHRLGI +IK ELE+L F 
Sbjct: 156 DVRVALIKLAERTCAIRAVKLADDEKRQRVAREVFDIYAPLAHRLGIGHIKWELEDLSFR 215

Query: 189 ALYPNRYRVLKEVVKAARGNRKEMIQRIHSEIEGRLQEVGLPARVVGREKNLFSIYNKMK 248
            L P +Y+ + +++   R +R++ IQ +  +++  L   G+   + GR K+++SI+ KM+
Sbjct: 216 YLEPEQYKQIAQLLHERRLDREQYIQNVVQQLKDELTATGIQPDIDGRAKHIYSIWRKMQ 275

Query: 249 TKEQRFHTIMDIYAFRIVVDTADTCYRVLGQVHSLYKPRPARMKDYIAVPKANGYQSLHT 308
            K  +F  I D+ A R++V     CY  LG VH+L++  P    DYIA PK NGY+SLHT
Sbjct: 276 KKGLQFSQIYDVRAVRVLVPEVRDCYTALGIVHTLWRHIPKEFDDYIANPKENGYRSLHT 335

Query: 309 SMVGPHGVPVEVQIRTEDMDQMADKGVAAHWSYKANSERGGTTAQIKAQRWMQSLLELQQ 368
           +++GP G  +EVQIRT  M + A+ GV AHW YK      G+    +   W++ +LE  +
Sbjct: 336 AVIGPEGKVLEVQIRTHAMHEEAELGVCAHWRYKGTDVNSGSDHYEEKIAWLRQVLEWHE 395

Query: 369 SAGNSFEFIENVKSDLFPDEIYVFTPKGRIVELPMGATAVDFAYAVHTDIGNTCVGARVD 428
             G+     + ++ D+ PD +YVFTP G  ++LP GAT +DFAY VHT+IG+ C GA+V+
Sbjct: 396 ELGDIGGLADQLRVDIEPDRVYVFTPDGHAIDLPKGATPLDFAYRVHTEIGHNCRGAKVN 455

Query: 429 RTPYPLSQSLKSGQTVEIISAPGARPNAAWLN----YVVTSRARTKIRQVLKTMRREDSI 484
               PL+ SL++G+ VEII++    P+  WLN    Y+ TSR+R KI    K   R+ ++
Sbjct: 456 GRIVPLNYSLQTGEQVEIITSKHGSPSRDWLNPNLGYITTSRSRAKIVHWFKLQARDQNV 515

Query: 485 TLGRRLLNHALGEHSVNEIAPENISKVLSDLKIASMDDLLAAIGLGELMSIVIARRLLGN 544
             G+ LL   LG     ++ P +  K+     + + +D+ AA+G G+L        L+  
Sbjct: 516 AAGKALLERELGR---LDLPPVDFDKLAEKANLKNAEDMFAALGAGDLR----LAHLVNM 568

Query: 545 ADELTEPSK---------------SGGNKNKLPIRGAEGILLTFANCCHPIPDDHIIAHV 589
           A +L EP +                 G +  + I+G   +L   A CC P+P D I+ ++
Sbjct: 569 AQQLVEPERGYDQLELIPRRSAPYKPGKRGDVQIQGVGNLLTQMAGCCQPLPGDPIVGYI 628

Query: 590 SPGRGLVVHRETCPNVRGYQ-KEPDKYMAVEWTKDYDQEFITELKVDMHNRQGALAELTN 648
           + GRG+ +HR+ CP+V     +EP++ + V W    ++ +  E+ +  ++R G L +++ 
Sbjct: 629 TQGRGVSIHRQDCPSVLQLAGREPERIIQVSWGPVPEKTYPVEIMIRAYDRAGLLRDISQ 688

Query: 649 VISKTGSNIHGLST-EERDGRLYTVTVLLTTKDRVHLAGIMRKIRTMPHALKVRRRK 704
           ++     N+  ++T   ++     +T+ +       L  ++ +I  +P+ ++ +R++
Sbjct: 689 MLLNERINVLSMNTRSNKEDSTAQMTLTIEIPGLNALGRLLSRISQLPNIIEAKRQR 745