Pairwise Alignments

Query, 705 a.a., bifunctional GTP diphosphokinase/guanosine-3',5'-bis(diphosphate) 3'-diphosphatase from Vibrio cholerae E7946 ATCC 55056

Subject, 715 a.a., (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA (NCBI) from Rhodospirillum rubrum S1H

 Score =  506 bits (1304), Expect = e-147
 Identities = 273/698 (39%), Positives = 411/698 (58%), Gaps = 18/698 (2%)

Query: 21  EALRQSYVVARDAHEGQTRSSGEPYIIHPVAVARILAEMRLDLETLQAALLHDVIEDCDV 80
           + L ++YV A   H  Q R+SG+PY  HP+ VA IL   +LD  ++  ALLHD IED + 
Sbjct: 23  DLLNRAYVYAMKMHGSQLRASGDPYFSHPIDVAGILTRYKLDCASIITALLHDTIEDTEA 82

Query: 81  TKEDLDAHFGSSVAELVDGVSKLDKLKFRDRKEAQAENFRKMVLAMVQDIRVILIKLADR 140
           T ED+   FG+ VA LVDGV+KL +++       QAENFRK++LAM +DIRV+++KLADR
Sbjct: 83  TLEDVRQLFGNDVARLVDGVTKLTRIQISSDHAKQAENFRKLLLAMSEDIRVLMVKLADR 142

Query: 141 THNMRTLGALR-PDKKRRIARETLEIYAPLAHRLGIHNIKTELEELGFEALYPNRYRVLK 199
            HNMRTL  +R P+K+ RIA ET+EIYAPLA R+G+  IK ELE+L F  LYP+    ++
Sbjct: 143 LHNMRTLHFIRKPEKRARIALETMEIYAPLAERIGMAEIKEELEDLAFRELYPDAKEGIE 202

Query: 200 EVVKAARGNRKEMIQRIHSEIEGRLQEVGLPARVVGREKNLFSIYNKMKTKEQRFHTIMD 259
             +   R     ++ ++  +++  L E GL A + GREK  +SI+ KMK K   F  + D
Sbjct: 203 ARLTFLREQGGTLVPKVIDQLKAALAEHGLTAEITGREKTPYSIWQKMKRKNISFEQLSD 262

Query: 260 IYAFRIVVDTADTCYRVLGQVHSLYKPRPARMKDYIAVPKANGYQSLHTSMVGPHGVPVE 319
           I AFRI V+  + CY+ LG +H+ Y   P R KDYI+ PK NGYQS+HT+++GP  + +E
Sbjct: 263 IMAFRITVENLEQCYQALGIIHASYPMIPDRFKDYISTPKRNGYQSIHTAVIGPERLRIE 322

Query: 320 VQIRTEDMDQMADKGVAAHWSYKANSERGGTTAQIKAQRWMQSLLELQQSAGNSFEFIEN 379
           +QIRT +M  +A+ GVAAHWSYK    +G      +  RW++ LLE+ +   +  EF+E+
Sbjct: 323 IQIRTAEMHSVAELGVAAHWSYK----QGSPVMDGRQYRWIRELLEILEHTSSPEEFLEH 378

Query: 380 VKSDLFPDEIYVFTPKGRIVELPMGATAVDFAYAVHTDIGNTCVGARVDRTPYPLSQSLK 439
            K ++F D+++ FTPKG ++ LP GAT VDFAYAVHT +G+ CV A+V+    PL   L 
Sbjct: 379 TKLEMFSDQVFCFTPKGDLIGLPSGATPVDFAYAVHTQVGDRCVSAKVNGRLVPLRTPLH 438

Query: 440 SGQTVEIISAPGARPNAAWLNYVVTSRARTKIRQVLKTMRREDSITLGRRLLNHALGEHS 499
           +G  VEI ++    P+  W  +VVT +AR +IR+ +++ RR+  + LGR+LL  A    +
Sbjct: 439 NGDQVEIATSKAQTPSPEWERFVVTGKARAQIRKFVRSQRRDQYLILGRQLLERAFKAEN 498

Query: 500 VNEIAPENISKVLSDLKIASMDDLLAAIGLGELMSIVIARRL---LGNADELTEPSKSGG 556
             E+  + +  VL   +  S++DL+  +G G+L +  + + +   L    +L      G 
Sbjct: 499 Y-EMTEKGLDGVLKKFRADSVEDLIVDVGEGQLPAREVVQAVYPGLKMVPKLAAVVTLGR 557

Query: 557 NK-------NKLPIRG-AEGILLTFANCCHPIPDDHIIAHVSPGRGLVVHRETCPNVRGY 608
            K       +   I+G   G+ L FA CCH +P D I+  V+ G+G+ +H   C  +  +
Sbjct: 558 TKKPRASDDHSFKIKGMIPGMALHFAKCCHSLPGDRIVGIVTTGKGITIHTIDCDQLEQF 617

Query: 609 QKEPDKYMAVEWTKDYD-QEFITELKVDMHNRQGALAELTNVISKTGSNIHGLSTEERDG 667
             EP++++ + W  + D Q  +  + V + N  G+L  LT VI+K   NI  L    R  
Sbjct: 618 SDEPERWLDLAWDAEADSQVHVGRVNVVVANEPGSLGALTTVIAKNLGNITNLKITNRQQ 677

Query: 668 RLYTVTVLLTTKDRVHLAGIMRKIRTMPHALKVRRRKN 705
             + + V +  KD  HL  I+  +R       V R ++
Sbjct: 678 DFFDMIVDVEVKDVRHLTNIIAALRATSAINYVERARH 715