Pairwise Alignments

Query, 835 a.a., penicillin-binding protein 1A from Vibrio cholerae E7946 ATCC 55056

Subject, 678 a.a., Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) from Mycobacterium tuberculosis H37Rv

 Score =  142 bits (359), Expect = 5e-38
 Identities = 107/311 (34%), Positives = 159/311 (51%), Gaps = 17/311 (5%)

Query: 23  ICIILGVTTIFGFYFYVKSDLPDVATLRDVQLQTPMQVFSQDGKLIAQF--GEKRRIPLK 80
           + I+L + T    Y  V  D+P    +R  Q+ T   + + DG  IA+    E  R+ + 
Sbjct: 1   VVILLPMVTFTMAYLIV--DVPKPGDIRTNQVST---ILASDGSEIAKIVPPEGNRVDVN 55

Query: 81  LEEMPKELIEAVIATEDSRYYEHYGFDPIGITRAAFAVLASGSASQGASTITQQLARNFF 140
           L ++P  + +AVIA ED  +Y + GF   G  RA    L  G   QG STITQQ  +N  
Sbjct: 56  LSQVPMHVRQAVIAAEDRNFYSNPGFSFTGFARAVKNNLFGGDL-QGGSTITQQYVKNAL 114

Query: 141 LSNEKK----VMRKVKEIFIAIHIEQLLSKQEILELYLNKIYLGYRSYGVGAAAQAYFGK 196
           + + +     +MRK KE+ IA  +    SK ++L+ YLN IY G  +YG+ AA++AYF K
Sbjct: 115 VGSAQHGWSGLMRKAKELVIATKMSGEWSKDDVLQAYLNIIYFGRGAYGISAASKAYFDK 174

Query: 197 EVKDLTLGEIALIAGLPKAPSTMNPIYSVERATNRRNVVLQRMLDEKYITKAEYDA-ARA 255
            V+ LT+ E AL+A L + PST++P    E A  R N VL  M++ K ++  +  A    
Sbjct: 175 PVEQLTVAEGALLAALIRRPSTLDPAVDPEGAHARWNWVLDGMVETKALSPNDRAAQVFP 234

Query: 256 EPVLPKYHGAEIELNAP--YVAEIARAWMVERYG--EEAAYTSGMNVYTTVDSKLQRAAN 311
           E V P    AE +   P   +       ++E +   E+   T G+ V TT+D + QRAA 
Sbjct: 235 ETVPPDLARAENQTKGPNGLIERQVTRELLELFNIDEQTLNTQGLVVTTTIDPQAQRAAE 294

Query: 312 QAAINNLLAYD 322
           +A    L   D
Sbjct: 295 KAVAKYLDGQD 305



 Score = 63.2 bits (152), Expect = 5e-14
 Identities = 74/317 (23%), Positives = 118/317 (37%), Gaps = 52/317 (16%)

Query: 424 RTQDGAITAWKLTQVPNANTAFVAMNPENGAVTALVGGFNFVHNKFNRATQSVRQVGSSI 483
           R  + A+  +   Q P+   A V+++P NGAV A  GG N   N F+ A Q+  Q GSS 
Sbjct: 291 RAAEKAVAKYLDGQDPDMRAAVVSIDPHNGAVRAYYGGDN--ANGFDFA-QAGLQTGSSF 347

Query: 484 KPFIYSAALNKGLTLATLINDAPINQWDESQGTAWRPKNSPPTYTGPTRLRIGLAQSKNV 543
           K F   AAL +G+ L   ++ +P+           +  N      G   +   L  S N 
Sbjct: 348 KVFALVAALEQGIGLGYQVDSSPLTV------DGIKITNVEGEGCGTCNIAEALKMSLNT 401

Query: 544 MAVRVLREV--GLDETREYLTRFGFKLD-------------QLPRSETIALGAGSLTPVQ 588
              R++ ++  G     +   + G                   P +  I LG      + 
Sbjct: 402 SYYRLMLKLNGGPQAVADAAHQAGIASSFPGVAHTLSEDGKGGPPNNGIVLGQYQTRVID 461

Query: 589 MAQGFSVFANNGYFVEPFYISRVENPFGNIEFSAEPKVVCHRECSSELDEFAEQDAASPY 648
           MA  ++  A +G +  P ++ +V +  G + F A           S  D   +Q      
Sbjct: 462 MASAYATLAASGIYHPPHFVQKVVSANGQVLFDA-----------STADNTGDQRIPKAV 510

Query: 649 APKVISEQNAFLTREMLYSNIWGGGEWSSDTGWNGTGWRAQALKRRDIGGKTGTTNDSKD 708
           A  V +           + N+ GG + ++ TG                  + G T  +KD
Sbjct: 511 ADNVTAAMEPIAGYSRGH-NLAGGRDSAAKTGTT----------------QFGDTTANKD 553

Query: 709 AWYNGYAPGIVGVAWVG 725
           AW  GY P +    WVG
Sbjct: 554 AWMVGYTPSLSTAVWVG 570