Pairwise Alignments

Query, 516 a.a., 2-isopropylmalate synthase from Vibrio cholerae E7946 ATCC 55056

Subject, 644 a.a., 2-isopropylmalate synthase LeuA (alpha-isopropylmalate synthase) (alpha-IPM synthetase) (IPMS) from Mycobacterium tuberculosis H37Rv

 Score =  103 bits (256), Expect = 2e-26
 Identities = 117/503 (23%), Positives = 212/503 (42%), Gaps = 53/503 (10%)

Query: 12  LRDGEQALSASLTVKEKLQIAYALERLGVDIIEAGFPVSSPGDFESVQTIAKN---IKNS 68
           LRDG QAL   ++   K ++   L R+G   IE GFP +S  DF+ V+ I +      + 
Sbjct: 79  LRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDV 138

Query: 69  RVCALSRAVAKDIDAAAEALKVAEAFRIHTFISTSTIHVQDKLRRSYDDVVAMAV----K 124
            +  L++   + I+   +A   A    +H + STS +  +   R +  +V A+A     K
Sbjct: 139 TIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARK 198

Query: 125 AVKHARQYTDD---VEFSCEDAGRTPIDNLCRMVEAAINAGART------INIPDTVGYT 175
            V+ A +Y       E+S E    T ++   ++ +A     A T       N+P TV  T
Sbjct: 199 CVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMT 258

Query: 176 VPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAIQAGARQVEGTINGIGER 235
            P+ +   I+ +   + N +  I+S+H H+D G +VA +     AGA ++EG + G GER
Sbjct: 259 TPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGER 318

Query: 236 AGNCALEEIAMIIKTRQELLGVTTGIKHDEISRTSKLVSQLCNMPIQSNKAIVGANAFSH 295
            GN  L  + + + +R    GV   I    I    + V     +P+       G   ++ 
Sbjct: 319 TGNVCLVTLGLNLFSR----GVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTA 374

Query: 296 SSGIHQDGMLKNKNTYEI--------------------MTPESIGLKNQA-LNLTSRSGR 334
            SG HQD + K  +  ++                    + P  +G   +A + + S+SG+
Sbjct: 375 FSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGK 434

Query: 335 AAVKSHMDSMGYNENEYNLDALYEDFLK-----LADRKGQVFD---YDLEALMHFSNLRE 386
             V   M +         L   +   ++      A   G+V     +D  A  + + +R 
Sbjct: 435 GGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRP 494

Query: 387 EDDFYK-LNYLSVQSGSVMATTSIKLLCGGEEKCEAAVGNGPVDALYQCIYRITGYEIVL 445
            +   + ++      G+   T ++K+   G E   +  GNGP+ A    +  + G+++ +
Sbjct: 495 LERIRQHVDAADDDGGTTSITATVKI--NGVETEISGSGNGPLAAFVHALADV-GFDVAV 551

Query: 446 DKFDLTAKGEGEDGLGQADIIAN 468
             +   A   G+D    A + A+
Sbjct: 552 LDYYEHAMSAGDDAQAAAYVEAS 574