Pairwise Alignments

Query, 761 a.a., DNA topoisomerase IV subunit A from Vibrio cholerae E7946 ATCC 55056

Subject, 877 a.a., DNA gyrase subunit A from Klebsiella michiganensis M5al

 Score =  383 bits (984), Expect = e-110
 Identities = 257/744 (34%), Positives = 412/744 (55%), Gaps = 71/744 (9%)

Query: 20  EDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLSASAKYKKSARTVGDVLGKY 79
           + +YL+Y+M VI+ RALP + DGLKPV RR++YAM+ LG   +  YKKSAR VGDV+GKY
Sbjct: 18  KSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKY 77

Query: 80  HPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEAKLSKFAEILLS 139
           HPHGD+A Y+ +V MAQPFS RY LVDGQGN+G+ D   S AAMRYTE ++SK A  L++
Sbjct: 78  HPHGDTAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDG-DSAAAMRYTEIRMSKIAHELMA 136

Query: 140 ELGQGTVDWQPNFDGTMQEPKMLPARLPHILLNGVTGIAVGMATDIPPHNVREVADATIH 199
           +L + TVD+  N+DGT + P ++P ++P++L+NG +GIAVGMAT+IPPHN+ EV +  + 
Sbjct: 137 DLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLA 196

Query: 200 LIDNPNAPLTDLMQYVKGPDFPTEAEIITPTVELEKIYRSGRGSIKMRA-----VWCKEG 254
            ++N +  +  LM+++ GPDFPT A II     +E+ YR+GRG + +RA        K G
Sbjct: 197 YVENEDISIEGLMEHIPGPDFPT-AAIINGRRGIEEAYRTGRGKVYIRARAEVEADAKTG 255

Query: 255 SD-IVITALPHQVSGAKLLEQIAAQMRAKKLPMVEDLRDESDHENPTRIVIVPRSNRVDC 313
            + I++  +P+QV+ A+L+E+IA  ++ K++  +  LRDESD +   RIVI  + + V  
Sbjct: 256 RETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDG-MRIVIEVKRDAVG- 313

Query: 314 DLLMNHLFASTDLEKSFRVNLNMIGLDN-RPQVKGLVQILSEWISFRRETVRSRLQYRLD 372
           ++++N+L++ T L+ SF   +NM+ L + +P++  L +I++ ++  RRE V  R  + L 
Sbjct: 314 EVVLNNLYSQTQLQVSF--GINMVALHHGQPKIMNLKEIIAAFVRHRREVVTRRTIFELR 371

Query: 373 KVLARLHILQGLLIAYLNLDEVIEIIRNEDDP---KAVLMAR------------------ 411
           K   R HIL+ L IA  N+D +IE+IR    P   KA L+AR                  
Sbjct: 372 KARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAGLIARSWDLGNVSAMLERAGDDA 431

Query: 412 ----------------FDLTDIQADAILDTKLRHLAKLEEMKIRGEQDELEKERKKLEEL 455
                           + LT+ QA AILD +L+ L  LE  K+  E  EL ++  +L  +
Sbjct: 432 ARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHI 491

Query: 456 LGSERRLNNLLKKEIKADADKFGDDRRSPLVEREEAKALTERDLMPSEAITVVLSEKGWI 515
           LGS  RL  ++++E++   ++FGD RR+ +     +  +   DL+  E + V LS +G++
Sbjct: 492 LGSADRLMEVIREELELVREQFGDARRTEIT--ANSADINIEDLINQEDVVVTLSHQGYV 549

Query: 516 RHAKGHDVDCQ--------SLNYKAGDNYLTHACGKSNQQAVFLGSDGRSYSLESHTLPS 567
           ++    D + Q        +   K  D         ++   +   S GR Y ++ + LP 
Sbjct: 550 KYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPE 609

Query: 568 A-RG-QGEPITGRLNVAEG---TTIRQVVMGEEDQLWLVGSDAGYGFVCKGDDLLSKNRS 622
           A RG +G PI   L +      T I  V   EE     + + +G        +      +
Sbjct: 610 ASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTALTEFSRPRSA 669

Query: 623 GKALINLPENSEVMTPQVIADLDNDEILAITNQGRMLLFPIKDLPQLSKGKGNKIINIPA 682
           G   +NL E  E++   + +    DE++  +  G+++ F         +  G     +  
Sbjct: 670 GIIAVNLNEGDELIGVDLTS--GQDEVMLFSAAGKVVRFK----EDAVRAMGRTATGVRG 723

Query: 683 AKAKTREEVLSNLMVLPQGASITL 706
            K    ++V+S ++   +GA +T+
Sbjct: 724 IKLAGEDKVVSLIVPRGEGAILTV 747